Yıl: 2021 Cilt: 84 Sayı: 1 Sayfa Aralığı: 40 - 47 Metin Dili: İngilizce DOI: 10.26650/IUITFD.2020.0044 İndeks Tarihi: 07-05-2021

THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TO- LYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA

Öz:
Objective: The neutrophil-to-lymphocyte ratio (NLR) has beenrecently proposed as a simple, inexpensive prognostic factor incancer patients. We aimed to investigate the prognostic mean-ing of pretreatment NLR in patients with lymphoma.Material and Method: Patients aged over 18 years with lym-phoma who were diagnosed, followed-up and treated betweenJanuary 2011 and December 2017 in the department of internalmedicine were enrolled in this study. The data of 82 patients (62NHL and 20 HL) were obtained retrospectively. The relationshipbetween the NLR and baseline characteristics, laboratory pa-rameters, prognosis, and survival outcome were evaluated.Results: In patients with HL, the older age group of the patientsat the time of diagnosis had a high mortality rate and pleu-ral effusion had a significant negative effect on OS (p=0.008,p=0.035). In patients with NHL, an advanced age, high IPI score,decreased PLT level and elevated beta 2 microglobulin were as-sociated with a high mortality rate (p=0.001, p=0.044, p=0.023,p=0.009).Conclusion: A relation between the NLR and mortality and OScould be not demonstrated in HL patients and NHL patients.The retrospective analysis with a small sample size, late-diag-nosed patients population and single-centre study may be thecauses of these unexpected results.
Anahtar Kelime:

LENFOMA HASTALARINDA NÖTROFİL LENFOSİT ORANININ PROGNOSTİK ÖNEMİ

Öz:
Amaç: Sistemik inflamasyon göstergesi olan nötrofil-lenfosit ora- nı (NLR), kanser hastalarında son zamanlarda önerilen basit veucuz bir prognostik faktördür. Çalışmamızda, tedavi öncesi yük- sek NLR değerinin lenfoma hastalarında kötü sağkalımı gösterdi- ği hipotezine dayanarak lenfoma hastalarında tedavi öncesi NLRdeğerlerinin geriye dönük prognostik anlamını inceledik.Gereç ve Yöntem: Çalışmamıza Ocak 2011 ve Aralık 2017 tarih- leri arasında İstanbul Tıp Fakültesi iç hastalıkları ve geriatri bölü- münde tanı konulan, takip ve tedavi edilmiş 18 yaş üstü lenfomatanılı hastalar dahil edildi. Sekseniki hastanın verileri retrospektif olarak hastane otomasyon sistemlerinden elde edildi. NLR vetemel karakteristikleri laboratuar parametreleri, prognoz ve sağ- kalım sonuçları arasındaki ilişki değerlendirildi.Bulgular: HL hastalarında, tanı anında daha ileri yaş grubundaki hastalarda yüksek mortalite hızı ve plevral efüzyonun varlığı uzun dönem sağkalım üzerine anlamlı negatif etkiye sahipti (p=0,008, p=0,035). NHL hastalarında, ileri yaş yüksek IPI skoru, düşük PLT seviyesi ve yüksek beta 2 mikroglobulin düzeyi yüksek mortalite oranıyla ilişkili bulundu (p=0,001, p=0,044, p=0,023, p=0,009). Sonuç: HL ve NHL hastalarında NLR ile mortalite ve uzun dönem sağkalım arasında bir ilişki gösterilememiştir. Bu retrospektif analizin küçük bir örneklem büyüklüğüne sahip olması, geç tanı konulmuş hasta popülasyonu ve tek merkezli bir çalışma olması bu beklenmedik sonucun nedeni olabilir.
Anahtar Kelime:

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APA Medetalibeyoglu A, Ates M, Altinkaynak M, Capar G, BAYRAKDAR S, Akpinar T, Tascioglu C (2021). THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TO- LYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA. , 40 - 47. 10.26650/IUITFD.2020.0044
Chicago Medetalibeyoglu Alpay,Ates Merve,Altinkaynak Mustafa,Capar Gazi,BAYRAKDAR SENA,Akpinar Timur,Tascioglu Cemil THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TO- LYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA. (2021): 40 - 47. 10.26650/IUITFD.2020.0044
MLA Medetalibeyoglu Alpay,Ates Merve,Altinkaynak Mustafa,Capar Gazi,BAYRAKDAR SENA,Akpinar Timur,Tascioglu Cemil THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TO- LYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA. , 2021, ss.40 - 47. 10.26650/IUITFD.2020.0044
AMA Medetalibeyoglu A,Ates M,Altinkaynak M,Capar G,BAYRAKDAR S,Akpinar T,Tascioglu C THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TO- LYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA. . 2021; 40 - 47. 10.26650/IUITFD.2020.0044
Vancouver Medetalibeyoglu A,Ates M,Altinkaynak M,Capar G,BAYRAKDAR S,Akpinar T,Tascioglu C THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TO- LYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA. . 2021; 40 - 47. 10.26650/IUITFD.2020.0044
IEEE Medetalibeyoglu A,Ates M,Altinkaynak M,Capar G,BAYRAKDAR S,Akpinar T,Tascioglu C "THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TO- LYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA." , ss.40 - 47, 2021. 10.26650/IUITFD.2020.0044
ISNAD Medetalibeyoglu, Alpay vd. "THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TO- LYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA". (2021), 40-47. https://doi.org/10.26650/IUITFD.2020.0044
APA Medetalibeyoglu A, Ates M, Altinkaynak M, Capar G, BAYRAKDAR S, Akpinar T, Tascioglu C (2021). THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TO- LYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA. İstanbul Tıp Fakültesi Dergisi, 84(1), 40 - 47. 10.26650/IUITFD.2020.0044
Chicago Medetalibeyoglu Alpay,Ates Merve,Altinkaynak Mustafa,Capar Gazi,BAYRAKDAR SENA,Akpinar Timur,Tascioglu Cemil THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TO- LYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA. İstanbul Tıp Fakültesi Dergisi 84, no.1 (2021): 40 - 47. 10.26650/IUITFD.2020.0044
MLA Medetalibeyoglu Alpay,Ates Merve,Altinkaynak Mustafa,Capar Gazi,BAYRAKDAR SENA,Akpinar Timur,Tascioglu Cemil THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TO- LYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA. İstanbul Tıp Fakültesi Dergisi, vol.84, no.1, 2021, ss.40 - 47. 10.26650/IUITFD.2020.0044
AMA Medetalibeyoglu A,Ates M,Altinkaynak M,Capar G,BAYRAKDAR S,Akpinar T,Tascioglu C THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TO- LYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA. İstanbul Tıp Fakültesi Dergisi. 2021; 84(1): 40 - 47. 10.26650/IUITFD.2020.0044
Vancouver Medetalibeyoglu A,Ates M,Altinkaynak M,Capar G,BAYRAKDAR S,Akpinar T,Tascioglu C THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TO- LYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA. İstanbul Tıp Fakültesi Dergisi. 2021; 84(1): 40 - 47. 10.26650/IUITFD.2020.0044
IEEE Medetalibeyoglu A,Ates M,Altinkaynak M,Capar G,BAYRAKDAR S,Akpinar T,Tascioglu C "THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TO- LYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA." İstanbul Tıp Fakültesi Dergisi, 84, ss.40 - 47, 2021. 10.26650/IUITFD.2020.0044
ISNAD Medetalibeyoglu, Alpay vd. "THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TO- LYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA". İstanbul Tıp Fakültesi Dergisi 84/1 (2021), 40-47. https://doi.org/10.26650/IUITFD.2020.0044