KANSERDE YENİ HEDEF: MİKROVEZİKÜLLER VE EKSOZOMLAR
Yıl: 2021 Cilt: 84 Sayı: 1 Sayfa Aralığı: 130 - 134 Metin Dili: Türkçe DOI: 10.26650/IUITFD.2020.0015 İndeks Tarihi: 07-05-2021
KANSERDE YENİ HEDEF: MİKROVEZİKÜLLER VE EKSOZOMLAR
Öz: Son yıllarda hücreler arası haberleşmede ekstrasellüler vezikülle-rin transferini içeren yeni bir mekanizma öne sürülmüştür. Çoğukanser hücresi protein, lipit, DNA ve mikroRNA’lardan oluşanekstrasellüler veziküller (EV’ler) salarak komşu hücre davranışı-nın değişmesine neden olabilmektedir. EV’lerin bir alt tipi olaneksozomlar hücreler arası iletişim sağlayan küresel şekilli, iki li-pit tabakalı membran ile çevrili keseciklerdir. Eksozomlar kansergelişimini, metastaz ve ilaç direncini kontrol etmek için yakın veuzak çevre kanser hücreleri ile iletişim kurarlar. Eksozomlar hücre-ler arası iletişimin yanısıra sinyal iletimi, genetik madde aktarımı,bağışıklık yanıtının düzenlenmesi gibi birçok biyolojik işlevde roloynar. EV’lerin tümör mikro çevresinde ve kanser metastazında al-ternatif bir haberleşme aracı olduğu ortaya çıkarılmıştır. Eksozom-lar çeşitli kanser tedavileri esnasında içeriklerini değiştirebildikle-rinden dolayı tedaviyi takip etmede önemli bir rol oynayabilirler.Bu derleme kanser tanı ve tedavisinin hedefi olarak komünikazom(hücreler arası haberleşme) olarak adlandırılan hücreler arasındasinyalleri ileten EV’lerin fonksiyonuna odaklanmaktadır.
Anahtar Kelime: NEW TARGET MICROVESICLES AND EXOSOMES IN CANCER
Öz: In recent years, a new mechanism for intercellular communication has been put forward which involves the intercellular transfer ofextracellular vesicles. Most cancer cells release potentially func- tional biomolecules loaded in extracellular vesicles (EVs) such asDNA, proteins, lipids, and microRNAs. The experiments showedthat EVs uptake by tumor cells can alter cellular behavior. Exo- somes, a subtype of EVs, are small, lipid bilayer membrane ves- icles for intercellular communication. Exosomes communicatewith near-by and distant cancer cells that promote cancer de- velopment, metastasis, and drug resistance. In addition to inter- cellular communication, exosomes play a role in many biologicalprocesses such as signal transmission, genetic material transfer, and regulation of the immune response. EVs have emerged asan alternative mediator of communication within the tumor mi- croenvironment and cancer metastasis. Because exosomes canchange their content during various cancer treatments, they canplay an important role in following the treatment. This review fo- cuses on the function of EVs as signal transmitters between cells,called communicasomes (intercellular communication), and the importance of this function in cancer diagnosis and treatment.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
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| APA | Bolkent S (2021). KANSERDE YENİ HEDEF: MİKROVEZİKÜLLER VE EKSOZOMLAR. , 130 - 134. 10.26650/IUITFD.2020.0015 |
| Chicago | Bolkent Sema KANSERDE YENİ HEDEF: MİKROVEZİKÜLLER VE EKSOZOMLAR. (2021): 130 - 134. 10.26650/IUITFD.2020.0015 |
| MLA | Bolkent Sema KANSERDE YENİ HEDEF: MİKROVEZİKÜLLER VE EKSOZOMLAR. , 2021, ss.130 - 134. 10.26650/IUITFD.2020.0015 |
| AMA | Bolkent S KANSERDE YENİ HEDEF: MİKROVEZİKÜLLER VE EKSOZOMLAR. . 2021; 130 - 134. 10.26650/IUITFD.2020.0015 |
| Vancouver | Bolkent S KANSERDE YENİ HEDEF: MİKROVEZİKÜLLER VE EKSOZOMLAR. . 2021; 130 - 134. 10.26650/IUITFD.2020.0015 |
| IEEE | Bolkent S "KANSERDE YENİ HEDEF: MİKROVEZİKÜLLER VE EKSOZOMLAR." , ss.130 - 134, 2021. 10.26650/IUITFD.2020.0015 |
| ISNAD | Bolkent, Sema. "KANSERDE YENİ HEDEF: MİKROVEZİKÜLLER VE EKSOZOMLAR". (2021), 130-134. https://doi.org/10.26650/IUITFD.2020.0015 |
| APA | Bolkent S (2021). KANSERDE YENİ HEDEF: MİKROVEZİKÜLLER VE EKSOZOMLAR. İstanbul Tıp Fakültesi Dergisi, 84(1), 130 - 134. 10.26650/IUITFD.2020.0015 |
| Chicago | Bolkent Sema KANSERDE YENİ HEDEF: MİKROVEZİKÜLLER VE EKSOZOMLAR. İstanbul Tıp Fakültesi Dergisi 84, no.1 (2021): 130 - 134. 10.26650/IUITFD.2020.0015 |
| MLA | Bolkent Sema KANSERDE YENİ HEDEF: MİKROVEZİKÜLLER VE EKSOZOMLAR. İstanbul Tıp Fakültesi Dergisi, vol.84, no.1, 2021, ss.130 - 134. 10.26650/IUITFD.2020.0015 |
| AMA | Bolkent S KANSERDE YENİ HEDEF: MİKROVEZİKÜLLER VE EKSOZOMLAR. İstanbul Tıp Fakültesi Dergisi. 2021; 84(1): 130 - 134. 10.26650/IUITFD.2020.0015 |
| Vancouver | Bolkent S KANSERDE YENİ HEDEF: MİKROVEZİKÜLLER VE EKSOZOMLAR. İstanbul Tıp Fakültesi Dergisi. 2021; 84(1): 130 - 134. 10.26650/IUITFD.2020.0015 |
| IEEE | Bolkent S "KANSERDE YENİ HEDEF: MİKROVEZİKÜLLER VE EKSOZOMLAR." İstanbul Tıp Fakültesi Dergisi, 84, ss.130 - 134, 2021. 10.26650/IUITFD.2020.0015 |
| ISNAD | Bolkent, Sema. "KANSERDE YENİ HEDEF: MİKROVEZİKÜLLER VE EKSOZOMLAR". İstanbul Tıp Fakültesi Dergisi 84/1 (2021), 130-134. https://doi.org/10.26650/IUITFD.2020.0015 |
