The therapeutic effect of naringin on ovarian and lung damages created by adnexal torsion/detorsion: A biochemical study

Ekinci Akdemir, Fazile Nur; TOPDAĞI YILMAZ, Emsal Pınar; TOPDAĞI, YUNUS EMRE; Eraslan, Ersen; tanyeli, ayhan; guler, mustafa can

doi:10.5455/annalsmedres.2020.07.680

The therapeutic effect of naringin on ovarian and lung damages created by adnexal torsion/detorsion: A biochemical study

Emsal Pınar TOPDAĞI YILMAZ, (Atatürk Üniversitesi, Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı, Erzurum, Türkiye)

Ayhan TANYELİ, (Atatürk Üniversitesi, Tıp Fakültesi Fizyoloji Anabilim Dalı, Erzurum, Türkiye)

Fazile Nur EKİNCİ AKDEMİR, (Ağrı İbrahim Çeçen Üniversitesi, Sağlık Yüksek Okulu, Beslenme ve Diyetetik Bölümü, Ağrı, Türkiye)

Ersen ERASLAN, (Yozgat Bozok Üniversitesi, Tıp Fakültesi Fizyoloji Anabilim Dalı, Yozgat, Türkiye)

Mustafa Can GÜLER, (Atatürk Üniversitesi, Tıp Fakültesi Fizyoloji Anabilim Dalı, Erzurum, Türkiye)

Yunus Emre TOPDAĞI (SANKO Üniversitesi, Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı, Gaziantep, Türkiye)

Annals of Medical Research

7 0

Yıl: 2020 Cilt: 27 Sayı: 9 Sayfa Aralığı: 2438 - 2442 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2020.07.680 İndeks Tarihi: 08-05-2021

The therapeutic effect of naringin on ovarian and lung damages created by adnexal torsion/detorsion: A biochemical study

Öz:

Aim: In this study, naringin was examined against injuries in lung and ovarian tissues caused by ovarian torsion/detorsion (T/D).Material and Methods: The animals were grouped as sham, T/D, 50 mg/kg Naringin and 100 mg/kg Naringin. In sham group, the abdomen was incised and then sutured but T/D model wasn’t performed. In T/D group, torsion and detorsion (ischemia 3 hours/ reperfusion 3 hours) were carried out. In naringin treatment groups, naringin was applied intraperitoneally at the doses of 50 and 100mg/kg about 30 minutes prior to detorsion. After detorsion period, experimental animals were immolated and the ovarian and lung tissues were excised, homogenized and the biochemical analyzes were done.Results: The activity of MPO, IL-1β, MDA, TNF-α levels, TOS and OSI parameters raised significantly but SOD activity and TAS values declined in T/D group when it is compared to sham group. On the other side, naringin treatments reversed these parameters.Conclusion: Thereby, naringin demonstrated therapeutic effect against the injuries of ovarian and lung tissues in rat T/D model.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Oelsner G, Cohen SB, Soriano D, et al. Minimal surgery for the twisted ischaemic adnexa can preserve ovarian function. Hum Reprod 2003;18:2599-602.
2. Oelsner G, Shashar D. Adnexal torsion. Clin Obstet Gynecol 2006;49:459-63.
3. Rey-Bellet Gasser C, Gehri M, Joseph JM, et al. Is It Ovarian Torsion? A Systematic Literature Review and Evaluation of Prediction Signs. Pediatr Emerg Care 2016;32:256-61.
4. Smolinski SE, Kreychman A, Catanzano T. Ovarian Torsion: Multimodality Review of Imaging Characteristics. J Comput Assist Tomogr 2015;39:922-4.
5. Huchon C, Fauconnier A. Adnexal torsion: a literature review. European journal of obstetrics, gynecology, and reproductive biology 2010;150:8-12.
6. Kroemer G, Galluzzi L, Brenner C. Mitochondrial membrane permeabilization in cell death. Physiological reviews 2007;87:99-163.
7. Broughton BR, Reutens DC, Sobey CG. Apoptotic mechanisms after cerebral ischemia. Stroke 2009;40:331-9.
8. Topdagi O, Tanyeli A, Ekinci Akdemir FN, et al. Barbaloin Attenuates Oxidative Testicular Injury Induced by Ischemia Reperfusion via Antioxidant Effects. Turkish Journal of Science 2020;5:28-33.
9. Casini A, Ceni E, Salzano R, et al. Neutrophil-derived superoxide anion induces lipid peroxidation and stimulates collagen synthesis in human hepatic stellate cells: role of nitric oxide. Hepatology (Baltimore, Md.) 1997;25:361-7.
10. Ito K, Ozasa H, Kojima N, Miura M, Iwa T, et al. Pharmacological preconditioning protects lung injury induced by intestinal ischemia/reperfusion in rat. Shock (Augusta, Ga.) 2003;19:462-8.
11. Kurt RK, Dogan AC, Dogan M, et al. Protective effect of colchicine on ovarian ischemia-reperfusion injury: an experimental study. Reprod Sci 2015;22:545-50.
12. Frederiks WM, Bosch KS. The role of xanthine oxidase in ischemia/reperfusion damage of rat liver. Histology and Histopathology 1995;10:111-6.
13. Woodman OL, Long R, Pons S, et al. The cardioprotectant 3',4'-dihydroxyflavonol inhibits opening of the mitochondrial permeability transition pore after myocardial ischemia and reperfusion in rats. Pharmacol Res 2014;81:26-33.
14. Eltzschig HK, Collard CD. Vascular ischaemia and reperfusion injury. British Med Bulletin 2004;70:71-86
15. Oguz A, Kapan M, Kaplan I, et al. The effects of sulforaphane on the liver and remote organ damage in hepatic ischemia-reperfusion model formed with pringle maneuver in rats. International J Surgery 2015;18:163-8.
16. Sahna E, Turk G, Atessahin A, et al. Remote organ injury induced by myocardial ischemia and reperfusion on reproductive organs, and protective effect of melatonin in male rats. Fertility and Sterility 2007;88:188-92.
17. Bharti S, Rani N, Krishnamurthy B, et al.. Preclinical evidence for the pharmacological actions of naringin: a review. Planta medica 2014;80:437-51.
18. Lavrador P, Gaspar VM, Mano JF. Bioinspired bone therapies using naringin: applications and advances. Drug discovery today 2018.;23:1293-304.
19. Chen R, Qi QL, Wang MT, et al. Therapeutic potential of naringin: an overview. Pharmaceutical biology 2016;54:3203-10.
20. Guler MC, Tanyeli A. Role of Hyperoside on Ovarian Tissue Damage Created by Ovarian Torsion Detorsion. New Trends in Medicine Sciences 2020;1:1-5.
21. Guler MC, Tanyeli A, Eraslan E, et al. Role of 6-Shogaol Against Ovarian Torsion Detorsion-Induced Reproductive Organ Damage. New Trends in Med Sciences 2020;1:29-34.
22. Amini N, Sarkaki A, Dianat M, et al. The renoprotective effects of naringin and trimetazidine on renal ischemia/reperfusion injury in rats through inhibition of apoptosis and downregulation of micoRNA-10a. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019;112:108568.
23. Ohkawa H, Ohishi N, Yagi K. Assay for Lipid Peroxides in Animal-Tissues by Thiobarbituric Acid Reaction. Anal Biochem 1979;95:351-8.
24. Sun Y, Oberley LW, Li Y. A Simple Method for Clinical Assay of Superoxide-Dismutase. Clin Chem 1988;34:497-500.
25. Bradley PP, Priebat DA, Christensen RD, et al.Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 1982;78:206-9.
26. Sengul O, Ferah I, Polat B, et al. Blockade of endothelin receptors with bosentan limits ischaemia/ reperfusion-induced injury in rat ovaries. Eur J Obstet Gynecol Reprod Biol 2013;170:458-63.
27. Refaie MMM, El-Hussieny M. The role of interleukin-1b and its antagonist (diacerein) in estradiol benzoateinduced endometrial hyperplasia and atypia in female rats. Fundamental & Clinical Pharmacology 2017;31:438-46.
28. Niki E, Yoshida Y, Saito Y, et al. Lipid peroxidation: mechanisms, inhibition, and biological effects. Biochem Biophys Res Commun 2005;338:668-76.
29. Bozkurt S, Arikan DC, Kurutas EB, et al. Selenium has a protective effect on ischemia/reperfusion injury in a rat ovary model: biochemical and histopathologic evaluation. J Pediatric Surgery 2012;47:1735-41.
30. Park E-S, Kim J, Ha T-u, et al. TDAG51 deficiency promotes oxidative stress-induced apoptosis through the generation of reactive oxygen species in mouse embryonic fibroblasts. Experimental & Molecular Med 2013;45:35.
31. Senbel AM, AbdelMoneim L, Omar AG. Celecoxib modulates nitric oxide and reactive oxygen species in kidney ischemia/reperfusion injury and rat aorta model of hypoxia/reoxygenation. Vascular Pharmacology 2014;62:24-31.
32. Yazici S, Demirtas S, Guclu O, et al. Using oxidant and antioxidant levels to predict the duration of both acute peripheral and mesenteric ischemia. Perfusion 2014;29:450-5.
33. Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clinical Biochemistry 2004;37:112-9.
34. NilamberLal Das R, Muruhan S, Nagarajan RP, et al. Naringin prevents ultraviolet-B radiation-induced oxidative damage and inflammation through activation of peroxisome proliferator-activated receptor gamma in mouse embryonic fibroblast (NIH-3T3) cells. J Biochem Mol Toxicol 2019;33:22263.
35. Lv Z, Wu W, Ge S, et al. Naringin protects against perfluorooctane sulfonate-induced liver injury by modulating NRF2 and NF-kappaB in mice. Int Immunopharmacol 2018;65:140-7.
36. Khodayar MJ, Kalantari H, Mahdavinia M, et al. Protective effect of naringin against BPA-induced cardiotoxicity through prevention of oxidative stress in male Wistar rats. Drug Chem Toxicol 2018;1-11.
37. Cui J, Wang G, Kandhare AD, et al. 2018. Neuroprotective effect of naringin, a flavone glycoside in quinolinic acid-induced neurotoxicity: Possible role of PPAR-gamma, Bax/Bcl-2, and caspase-3. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 121:95-108
38. Zhou C, Lai Y, Huang P, Xie L, Lin H, et al. Naringin attenuates alcoholic liver injury by reducing lipid accumulation and oxidative stress. Life Sciences 2019;216:305-12.
39. Kim JK, Park JH, Ku HJ, et al. Naringin protects acroleininduced pulmonary injuries through modulating apoptotic signaling and inflammation signaling pathways in mice. J Nutr Biochem 2018;59:10-6.
40. Gelen V, Sengul E, Yildirim S, et al. The protective effects of naringin against 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats. Iran J Basic Med Sci 2018;21:404-10.

APA	TOPDAĞI YILMAZ E, tanyeli a, Ekinci Akdemir F, Eraslan E, guler m, TOPDAĞI Y (2020). The therapeutic effect of naringin on ovarian and lung damages created by adnexal torsion/detorsion: A biochemical study. , 2438 - 2442. 10.5455/annalsmedres.2020.07.680
Chicago	TOPDAĞI YILMAZ Emsal Pınar,tanyeli ayhan,Ekinci Akdemir Fazile Nur,Eraslan Ersen,guler mustafa can,TOPDAĞI YUNUS EMRE The therapeutic effect of naringin on ovarian and lung damages created by adnexal torsion/detorsion: A biochemical study. (2020): 2438 - 2442. 10.5455/annalsmedres.2020.07.680
MLA	TOPDAĞI YILMAZ Emsal Pınar,tanyeli ayhan,Ekinci Akdemir Fazile Nur,Eraslan Ersen,guler mustafa can,TOPDAĞI YUNUS EMRE The therapeutic effect of naringin on ovarian and lung damages created by adnexal torsion/detorsion: A biochemical study. , 2020, ss.2438 - 2442. 10.5455/annalsmedres.2020.07.680
AMA	TOPDAĞI YILMAZ E,tanyeli a,Ekinci Akdemir F,Eraslan E,guler m,TOPDAĞI Y The therapeutic effect of naringin on ovarian and lung damages created by adnexal torsion/detorsion: A biochemical study. . 2020; 2438 - 2442. 10.5455/annalsmedres.2020.07.680
Vancouver	TOPDAĞI YILMAZ E,tanyeli a,Ekinci Akdemir F,Eraslan E,guler m,TOPDAĞI Y The therapeutic effect of naringin on ovarian and lung damages created by adnexal torsion/detorsion: A biochemical study. . 2020; 2438 - 2442. 10.5455/annalsmedres.2020.07.680
IEEE	TOPDAĞI YILMAZ E,tanyeli a,Ekinci Akdemir F,Eraslan E,guler m,TOPDAĞI Y "The therapeutic effect of naringin on ovarian and lung damages created by adnexal torsion/detorsion: A biochemical study." , ss.2438 - 2442, 2020. 10.5455/annalsmedres.2020.07.680
ISNAD	TOPDAĞI YILMAZ, Emsal Pınar vd. "The therapeutic effect of naringin on ovarian and lung damages created by adnexal torsion/detorsion: A biochemical study". (2020), 2438-2442. https://doi.org/10.5455/annalsmedres.2020.07.680

APA	TOPDAĞI YILMAZ E, tanyeli a, Ekinci Akdemir F, Eraslan E, guler m, TOPDAĞI Y (2020). The therapeutic effect of naringin on ovarian and lung damages created by adnexal torsion/detorsion: A biochemical study. Annals of Medical Research, 27(9), 2438 - 2442. 10.5455/annalsmedres.2020.07.680
Chicago	TOPDAĞI YILMAZ Emsal Pınar,tanyeli ayhan,Ekinci Akdemir Fazile Nur,Eraslan Ersen,guler mustafa can,TOPDAĞI YUNUS EMRE The therapeutic effect of naringin on ovarian and lung damages created by adnexal torsion/detorsion: A biochemical study. Annals of Medical Research 27, no.9 (2020): 2438 - 2442. 10.5455/annalsmedres.2020.07.680
MLA	TOPDAĞI YILMAZ Emsal Pınar,tanyeli ayhan,Ekinci Akdemir Fazile Nur,Eraslan Ersen,guler mustafa can,TOPDAĞI YUNUS EMRE The therapeutic effect of naringin on ovarian and lung damages created by adnexal torsion/detorsion: A biochemical study. Annals of Medical Research, vol.27, no.9, 2020, ss.2438 - 2442. 10.5455/annalsmedres.2020.07.680
AMA	TOPDAĞI YILMAZ E,tanyeli a,Ekinci Akdemir F,Eraslan E,guler m,TOPDAĞI Y The therapeutic effect of naringin on ovarian and lung damages created by adnexal torsion/detorsion: A biochemical study. Annals of Medical Research. 2020; 27(9): 2438 - 2442. 10.5455/annalsmedres.2020.07.680
Vancouver	TOPDAĞI YILMAZ E,tanyeli a,Ekinci Akdemir F,Eraslan E,guler m,TOPDAĞI Y The therapeutic effect of naringin on ovarian and lung damages created by adnexal torsion/detorsion: A biochemical study. Annals of Medical Research. 2020; 27(9): 2438 - 2442. 10.5455/annalsmedres.2020.07.680
IEEE	TOPDAĞI YILMAZ E,tanyeli a,Ekinci Akdemir F,Eraslan E,guler m,TOPDAĞI Y "The therapeutic effect of naringin on ovarian and lung damages created by adnexal torsion/detorsion: A biochemical study." Annals of Medical Research, 27, ss.2438 - 2442, 2020. 10.5455/annalsmedres.2020.07.680
ISNAD	TOPDAĞI YILMAZ, Emsal Pınar vd. "The therapeutic effect of naringin on ovarian and lung damages created by adnexal torsion/detorsion: A biochemical study". Annals of Medical Research 27/9 (2020), 2438-2442. https://doi.org/10.5455/annalsmedres.2020.07.680