The subject of our study is ceramic plate depicting a woman spinning yarn/wool in Tokat Museum collection, and reflecting the multicultural environment in Anatolia. The political, military, commercial and similar relationships between Anatolian Seljuks, who adopted Anatolia after 1071 Battle of Malazgirt, and the Byzantine Empire has created an intercultural interaction and also a source for artistic interaction. Similar style and iconographic artworks are seen in medieval art production especially in especially in carriable goods such as ceramic and fabric having traces of Byzantine and Seljuk cultures in Anatolian geography. The fact that some common patterns such as figures, geometry and writing imitation are seen in art works of both cultures is related to regional influence, constructor, role of artist and appreciation during the period. In the work of art examined in our study, ceramic plate depicting a woman spinning yarn/wool which has an important place in Byzantine culture and depiction, decoration elements reflecting Anatolian Seljuk figure tradition along with Byzantine painting tradition are seen. The work of art having traces from both cultures carries great importance as a unique example in terms of subject and style reflecting artistic interaction of Byzantine-Seljuk in Middle Age.