Objective: Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) disease (COVID-19) is still showing its effectas a major problem all over the world. Currently, antibody responses to SARS-CoV-2 are not fully understood, and theclinical benefits of serological testing are uncertain. In this study, antibody levels of patients with COVID-19 wereevaluated with Roche SARS-CoV-2 antibody test in samples taken at different times.Method: SARS-CoV-2 PCR tests of 21 people were examined in our hospital between March 2020 and April 2020, andserum samples were collected again in July 2020 and Roche SARS-CoV-2 antibody levels were measured in a total of 42samples.Results: Anti SARS CoV 2 antibodies were found to be negative in 7 of the first samples of 21 people and Anti SARS CoV2 antibodies were found to be positive in 14 of them. RT-PCR results were found to be positive in all of these 7 negativesamples. Anti-SARS-CoV-2 antibodies were found to be negative in 1 of the second samples, and Anti-SARS-CoV-2antibodies were found to be positive in 20 of them. Considering the second samples of all subjects, no decrease wasdetected in the SARS-CoV-2 antibody values in any sample. Conclusions: In the study, there are samples with negative antibody levels and partially low cut off index values even inthe second samples. This study is important in terms of both the presence and follow-up of antibody levels and detectionof donor antibody levels in plasmapheresis.