Cytotoxic Activities of Methanol Extract and Compounds of Porodaedalea pini Against Colorectal Cancer

Ebru Deveci, (Konya Teknik Üniversitesi, Teknik Bilimler Meslek Yüksekokulu, Kimya ve Kimyasal İşleme Teknolojileri Bölümü, Konya, Türkiye)
Gülsen Tel Çayan, (Muğla Sıtkı Koçman Üniversitesi, Muğla Meslek Yüksekokulu, Kimya ve Kimyasal İşleme Teknolojileri Bölümü, Muğla, Türkiye)
Serdar Karakurt, (Selçuk Üniversitesi, Fen Fakültesi, Biyokimya Bölümü, Konya, Türkiye)
Mehmet Emin DURU (Muğla Sıtkı Koçman Üniversitesi, Fen Fakültesi Kimya Bölümü, Muğla, Türkiye)
International Journal of Secondary Metabolite
6 0
Yıl: 2021 Cilt: 8 Sayı: 1 Sayfa Aralığı: 40 - 48 Metin Dili: İngilizce DOI: 10.21448/ ijsm.793715 İndeks Tarihi: 02-06-2021

Cytotoxic Activities of Methanol Extract and Compounds of Porodaedalea pini Against Colorectal Cancer

Öz:
Porodaedalea pini is a medicinally important mushroom withantioxidant, cytotoxic, immunostimulating, antitumor, antiviral andimmunomodulating activities. Therefore, in this study, P. pini methanol extractand isolated compounds from the methanol extract were tested for cytotoxicactivities against DLD-1 (colorectal cancer) and CCD-18Co (human colonfibroblast cell line) by using Alamar Blue assay. Cytotoxic activity on DLD-1was decreased in the order of P. pini methanol extract> 4-(3,4-dihydroxyphenyl)but-3-en-2-one (3)> pinoresinol (2)> ergosta-7,24(28)-dien3β-ol (1). P. pini methanol extract was determined to have the best cytotoxicactivity with the lowest IC50 value on DLD-1 (IC50: 25.33±0.29 µg/mL) and thehighest IC50 value on CCD-18Co (434.30±1.45 µg/mL). Within the scope of thefindings, it is thought that P. pini mushroom can be used as a new and naturalagent in the treatment of colorectal cancer.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Deveci E, Tel-Çayan G, Karakurt S, DURU M (2021). Cytotoxic Activities of Methanol Extract and Compounds of Porodaedalea pini Against Colorectal Cancer. , 40 - 48. 10.21448/ ijsm.793715
Chicago Deveci Ebru,Tel-Çayan Gulsen,Karakurt Serdar,DURU Mehmet Emin Cytotoxic Activities of Methanol Extract and Compounds of Porodaedalea pini Against Colorectal Cancer. (2021): 40 - 48. 10.21448/ ijsm.793715
MLA Deveci Ebru,Tel-Çayan Gulsen,Karakurt Serdar,DURU Mehmet Emin Cytotoxic Activities of Methanol Extract and Compounds of Porodaedalea pini Against Colorectal Cancer. , 2021, ss.40 - 48. 10.21448/ ijsm.793715
AMA Deveci E,Tel-Çayan G,Karakurt S,DURU M Cytotoxic Activities of Methanol Extract and Compounds of Porodaedalea pini Against Colorectal Cancer. . 2021; 40 - 48. 10.21448/ ijsm.793715
Vancouver Deveci E,Tel-Çayan G,Karakurt S,DURU M Cytotoxic Activities of Methanol Extract and Compounds of Porodaedalea pini Against Colorectal Cancer. . 2021; 40 - 48. 10.21448/ ijsm.793715
IEEE Deveci E,Tel-Çayan G,Karakurt S,DURU M "Cytotoxic Activities of Methanol Extract and Compounds of Porodaedalea pini Against Colorectal Cancer." , ss.40 - 48, 2021. 10.21448/ ijsm.793715
ISNAD Deveci, Ebru vd. "Cytotoxic Activities of Methanol Extract and Compounds of Porodaedalea pini Against Colorectal Cancer". (2021), 40-48. https://doi.org/10.21448/ ijsm.793715
APA Deveci E, Tel-Çayan G, Karakurt S, DURU M (2021). Cytotoxic Activities of Methanol Extract and Compounds of Porodaedalea pini Against Colorectal Cancer. International Journal of Secondary Metabolite, 8(1), 40 - 48. 10.21448/ ijsm.793715
Chicago Deveci Ebru,Tel-Çayan Gulsen,Karakurt Serdar,DURU Mehmet Emin Cytotoxic Activities of Methanol Extract and Compounds of Porodaedalea pini Against Colorectal Cancer. International Journal of Secondary Metabolite 8, no.1 (2021): 40 - 48. 10.21448/ ijsm.793715
MLA Deveci Ebru,Tel-Çayan Gulsen,Karakurt Serdar,DURU Mehmet Emin Cytotoxic Activities of Methanol Extract and Compounds of Porodaedalea pini Against Colorectal Cancer. International Journal of Secondary Metabolite, vol.8, no.1, 2021, ss.40 - 48. 10.21448/ ijsm.793715
AMA Deveci E,Tel-Çayan G,Karakurt S,DURU M Cytotoxic Activities of Methanol Extract and Compounds of Porodaedalea pini Against Colorectal Cancer. International Journal of Secondary Metabolite. 2021; 8(1): 40 - 48. 10.21448/ ijsm.793715
Vancouver Deveci E,Tel-Çayan G,Karakurt S,DURU M Cytotoxic Activities of Methanol Extract and Compounds of Porodaedalea pini Against Colorectal Cancer. International Journal of Secondary Metabolite. 2021; 8(1): 40 - 48. 10.21448/ ijsm.793715
IEEE Deveci E,Tel-Çayan G,Karakurt S,DURU M "Cytotoxic Activities of Methanol Extract and Compounds of Porodaedalea pini Against Colorectal Cancer." International Journal of Secondary Metabolite, 8, ss.40 - 48, 2021. 10.21448/ ijsm.793715
ISNAD Deveci, Ebru vd. "Cytotoxic Activities of Methanol Extract and Compounds of Porodaedalea pini Against Colorectal Cancer". International Journal of Secondary Metabolite 8/1 (2021), 40-48. https://doi.org/10.21448/ ijsm.793715
Sayfa Oluşturulma Tarihi
04-04-2024 3:8

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