An Overview about Adverse Hepatic Effects of the Plants Used in Turkey

Gürbüz, Perihan

An Overview about Adverse Hepatic Effects of the Plants Used in Turkey

Perihan Gürbüz (İnönü Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Malatya, Türkiye)

Cerrahpaşa Medical Journal

6 0

Yıl: 2020 Cilt: 44 Sayı: 3 Sayfa Aralığı: 115 - 124 Metin Dili: İngilizce İndeks Tarihi: 02-06-2021

An Overview about Adverse Hepatic Effects of the Plants Used in Turkey

Öz:

Herbal supplements are widely used for improving health and treating diseases in nearly all cultures of the world. However, the efficacy, safety, and drug interactions of many of the herbal treatment modalities are not known scientifically, and they are generally used without professional health assistance. Injudicious plant usage has been shown to be a risk factor for serious and unexpected side effects, and from this perspective, herbal drug usage is related to 25%–30% of drug-induced liver injury cases. Plant usage as an alternative therapeutic modality is common in Turkey. In this study, the adverse hepatic effects of the commonly used plants in Turkey has been reviewed. More than 400 plants that are sold by herbalists in different regions of Turkey have been obtained from various studies on this topic, and these plants were investigated for their hepatic effects in PubMed and Science Direct databases. The adverse hepatic outcomes of 27 of the researched plants. Studies about plant hepatotoxicity, plant-plant interaction, and plant-drug interaction have been reviewed in this article. Herbal modalities are widely used as an alternative and complementary treatment method in the population; however, the basic hepatotoxic compounds and the liver injury mechanism of many of the frequently used plants and the molecular action mechanism of most of the ingredient compounds of the plants are not exactly known. Multidisciplinary studies on the mentioned topics will be helpful in understanding the role of plants and hepatotoxicity in medical approaches.

Anahtar Kelime:

Türkiye’de Kullanılan Bitkilerin Karaciğer Üzerine Olumsuz Etkilerine Genel Bir Bakış

Öz:

Bitkisel takviyeler, dünyanın neredeyse tüm kültürlerinde sağlığı iyileştirmek ve hastalık tedavisi için yaygın olarak kullanılmaktadır. Bununla birlikte, kullanılan bitkisel tedavi yöntemlerinin birçoğunun etkinliği, güvenliği ve ilaç etkileşimleri bilimsel olarak bilinmemektedir ve genellikle profesyonel sağlık yardımı olmadan kullanılırlar. Bilinçsiz bitki kullanımının ciddi beklenmedik yan etkiler için bir risk faktörü olduğu gösterilmiştir ve bu açıdan bitkisel ilaç kullanımı ilaca bağlı karaciğer hasarı vakalarının %25-30’u ile ilgilidir. Alternatif bir tedavi yöntemi olarak bitki kullanımı Türkiye’de de yaygındır. Bu araştırmada, Türkiye’de yaygın olarak kullanılan bitkilerin karaciğer üzerine olumsuz etkilerinin gözden geçirilmesi planlanmıştır. Türkiye’nin farklı bölgelerinde aktarlar tarafından satılan 400’den fazla bitki bu konudaki çeşitli araştırmalardan tespit edilmiş ve belirlenen bitkiler Pubmed ve Science Direct veritabanlarında hepatik etkileri açısından araştırılmıştır. Belirlenen bitkilerin yirmiyedisinin olumsuz hepatik sonuçları olduğu saptandı. Bitki hepatotoksisitesi, bitki-bitki etkileşimi ve bitki-ilaç etkileşimi konuları hakkında belirlenen çalışmalar ana metinde ele alınmıştır. Bitkisel yöntemler toplumda alternatif ve tamamlayıcı bir tedavi metodu olarak yaygın olarak kullanılmalarına rağmen, sık kullanılan bitkilerin çoğunun temel hepatotoksik bileşikleri ve karaciğer hasar mekanizması, ve bitkilerin bileşiklerinin çoğunun moleküler etki mekanizması tam olarak bilinmemektedir. Bahsedilen konularda yapılacak multidisipliner çalışmalar, tıbbi yaklaşımlarda bitkilerin rolünü ve hepatotoksisiteyi anlamada yardımcı olacaktır.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	Gürbüz P (2020). An Overview about Adverse Hepatic Effects of the Plants Used in Turkey. , 115 - 124.
Chicago	Gürbüz Perihan An Overview about Adverse Hepatic Effects of the Plants Used in Turkey. (2020): 115 - 124.
MLA	Gürbüz Perihan An Overview about Adverse Hepatic Effects of the Plants Used in Turkey. , 2020, ss.115 - 124.
AMA	Gürbüz P An Overview about Adverse Hepatic Effects of the Plants Used in Turkey. . 2020; 115 - 124.
Vancouver	Gürbüz P An Overview about Adverse Hepatic Effects of the Plants Used in Turkey. . 2020; 115 - 124.
IEEE	Gürbüz P "An Overview about Adverse Hepatic Effects of the Plants Used in Turkey." , ss.115 - 124, 2020.
ISNAD	Gürbüz, Perihan. "An Overview about Adverse Hepatic Effects of the Plants Used in Turkey". (2020), 115-124.

APA	Gürbüz P (2020). An Overview about Adverse Hepatic Effects of the Plants Used in Turkey. Cerrahpaşa Medical Journal, 44(3), 115 - 124.
Chicago	Gürbüz Perihan An Overview about Adverse Hepatic Effects of the Plants Used in Turkey. Cerrahpaşa Medical Journal 44, no.3 (2020): 115 - 124.
MLA	Gürbüz Perihan An Overview about Adverse Hepatic Effects of the Plants Used in Turkey. Cerrahpaşa Medical Journal, vol.44, no.3, 2020, ss.115 - 124.
AMA	Gürbüz P An Overview about Adverse Hepatic Effects of the Plants Used in Turkey. Cerrahpaşa Medical Journal. 2020; 44(3): 115 - 124.
Vancouver	Gürbüz P An Overview about Adverse Hepatic Effects of the Plants Used in Turkey. Cerrahpaşa Medical Journal. 2020; 44(3): 115 - 124.
IEEE	Gürbüz P "An Overview about Adverse Hepatic Effects of the Plants Used in Turkey." Cerrahpaşa Medical Journal, 44, ss.115 - 124, 2020.
ISNAD	Gürbüz, Perihan. "An Overview about Adverse Hepatic Effects of the Plants Used in Turkey". Cerrahpaşa Medical Journal 44/3 (2020), 115-124.