Diagnostic Values of Clusterin and α-Klotho Levels in Patients with Sarcoidosis

AKDAĞ, Turan; Korkmaz, Celalettin

doi:10.30733/std.2021.01492

Diagnostic Values of Clusterin and α-Klotho Levels in Patients with Sarcoidosis

Turan AKDAĞ, (Necmettin Erbakan Üniversitesi , Meram Meslek Yüksekokulu)

Celalettin KORKMAZ (Necmettin Erbakan Üniversitesi , Meram Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı)

Selçuk Tıp Dergisi

3 0

Yıl: 2021 Cilt: 37 Sayı: 1 Sayfa Aralığı: 39 - 44 Metin Dili: İngilizce DOI: 10.30733/std.2021.01492 İndeks Tarihi: 04-06-2021

Diagnostic Values of Clusterin and α-Klotho Levels in Patients with Sarcoidosis

Öz:

Aim: Sarcoidosis is a multifactorial disease with unknown aetiology and characterized by non-caseousgranulomatous inflammation. The pathogenesis of sarcoidosis is defined as inflammation and autoimmuneactivation. Here, we aimed to evaluate plasma clusterin (CLU) and α-klotho levels in those with sarcoidosis.Patients and Methods: Forty patients with sarcoidosis (mean age: 52.10±12.60 years; 12 males, 28females) and 40 healthy volunteers (mean age: 37.40±18.20 years; 12 males, 28 females) betweenNovember 2019-March 2020 were enrolled into the study. Blood samples were drawn from both groups,and plasma CLU and α-klotho levels were investigated by enzyme-linked immunosorbent assay (ELISA)technique.Results: Patients with sarcoidosis had significantly higher plasma CLU levels (309.73±40.68 ng/mL),compared with healthy controls (117.86±102.03 ng/mL) (p=0.005). The plasma levels of α-klotho weremeasured as 5.34±7.30 in the sarcoidosis patients and 7.21±9.84 ng/mL in the controls. A minimaldecrease was observed, but there was no statistically significant difference (p=0.338). The hemoglobinlevels of sarcoidosis patients were decreased, when compared with the control group (12.93±1.02 g/dLvs 14.06±1.50 g/dL) (p=0.012).Conclusion: We concluded that sarcoidosis is associated with high levels of CLU. Plasma CLU may be apotential biomarker of sarcoidosis. Based on literature and to the best of our knowledge, this is the firststudy to provide insight in the determination of plasma levels of CLU and α-klotho in sarcoidosis. Furtherand comprehensive investigations are needed to clarify the enti ty.

Anahtar Kelime:

Sarkoidozlu Hastalarda Clusterin ve α-Klotho Düzeylerinin Tanısal Değerleri

Öz:

Amaç: Sarkoidoz, etiyolojisi bilinmeyen ve non-kazeifiye granülomatöz inflamasyon ile karakterize multifaktöriyel bir hastalıktır. Sarkoidoz patogenezi ise inflamasyon ve otoimmün aktivasyon olarak tanımlanır. Bu nedenle sarkoidoz hastalığında plazma clusterin ve α-klotho düzeylerini değerlendirmeyi amaçladık. Hastalar ve Yöntem: Sarkoidozlu 40 hasta (ortalama yaş: 52,10±12.60 yıl; 12 erkek, 28 kadın) ve 40 sağlıklı gönüllü (ortalama yaş: 37,40±18.20 yıl; 12 erkek, 28 kadın) Kasım 2019-Mart 2020 tarihleri arasında çalışmaya alındı. Her iki gruptan alınan kan örnekleri ile plazma clusterin ve α-klotho düzeyleri enzime bağlı immünosorban testi (ELISA) ile araştırıldı. Bulgular: Sarkoidozlu hastalarda plazma clusterin düzeyleri (309.73±40.68 ng/ml) sağlıklı gruba (117.86±102.03 ng/ml) kıyasla anlamlı olarak daha yüksekti (p=0.005). α-klotho plazma düzeyleri ise sarkoidoz grubunda 5.34±7.30 ng/ml ve sağlıklı grupta 7.21±9.84 ng/ml olarak belirlendi, minimal bir azalma gözlendi ancak istatistiksel olarak anlamlı bir fark yoktu (p=0.338). Sarkoidozlu hastaların hemoglobin düzeylerinin sağlıklı gruba göre azaldığı belirlendi (12.93±1.02 g/dL'ye karşılık 14.06±1.50 g/ dL) (p=0.012). Sonuç: Sarkoidozun bağımsız olarak yüksek seviyelerde clusterin ile ilişkili olduğu sonucuna varıldı. Plazma clusterin düzeyleri sarkoidoz için potansiyel bir biyobelirteç olabilir. Literatüre göre bu çalışma, sarkoidozda clusterin ve α-klotho' nun plazma seviyeleri için bilgi verilen ilk çalışmadır. Bu konuda daha fazla ve kapsamlı araştırmalara ihtiyaç vardır .

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	AKDAĞ T, Korkmaz C (2021). Diagnostic Values of Clusterin and α-Klotho Levels in Patients with Sarcoidosis. , 39 - 44. 10.30733/std.2021.01492
Chicago	AKDAĞ Turan,Korkmaz Celalettin Diagnostic Values of Clusterin and α-Klotho Levels in Patients with Sarcoidosis. (2021): 39 - 44. 10.30733/std.2021.01492
MLA	AKDAĞ Turan,Korkmaz Celalettin Diagnostic Values of Clusterin and α-Klotho Levels in Patients with Sarcoidosis. , 2021, ss.39 - 44. 10.30733/std.2021.01492
AMA	AKDAĞ T,Korkmaz C Diagnostic Values of Clusterin and α-Klotho Levels in Patients with Sarcoidosis. . 2021; 39 - 44. 10.30733/std.2021.01492
Vancouver	AKDAĞ T,Korkmaz C Diagnostic Values of Clusterin and α-Klotho Levels in Patients with Sarcoidosis. . 2021; 39 - 44. 10.30733/std.2021.01492
IEEE	AKDAĞ T,Korkmaz C "Diagnostic Values of Clusterin and α-Klotho Levels in Patients with Sarcoidosis." , ss.39 - 44, 2021. 10.30733/std.2021.01492
ISNAD	AKDAĞ, Turan - Korkmaz, Celalettin. "Diagnostic Values of Clusterin and α-Klotho Levels in Patients with Sarcoidosis". (2021), 39-44. https://doi.org/10.30733/std.2021.01492

APA	AKDAĞ T, Korkmaz C (2021). Diagnostic Values of Clusterin and α-Klotho Levels in Patients with Sarcoidosis. Selçuk Tıp Dergisi, 37(1), 39 - 44. 10.30733/std.2021.01492
Chicago	AKDAĞ Turan,Korkmaz Celalettin Diagnostic Values of Clusterin and α-Klotho Levels in Patients with Sarcoidosis. Selçuk Tıp Dergisi 37, no.1 (2021): 39 - 44. 10.30733/std.2021.01492
MLA	AKDAĞ Turan,Korkmaz Celalettin Diagnostic Values of Clusterin and α-Klotho Levels in Patients with Sarcoidosis. Selçuk Tıp Dergisi, vol.37, no.1, 2021, ss.39 - 44. 10.30733/std.2021.01492
AMA	AKDAĞ T,Korkmaz C Diagnostic Values of Clusterin and α-Klotho Levels in Patients with Sarcoidosis. Selçuk Tıp Dergisi. 2021; 37(1): 39 - 44. 10.30733/std.2021.01492
Vancouver	AKDAĞ T,Korkmaz C Diagnostic Values of Clusterin and α-Klotho Levels in Patients with Sarcoidosis. Selçuk Tıp Dergisi. 2021; 37(1): 39 - 44. 10.30733/std.2021.01492
IEEE	AKDAĞ T,Korkmaz C "Diagnostic Values of Clusterin and α-Klotho Levels in Patients with Sarcoidosis." Selçuk Tıp Dergisi, 37, ss.39 - 44, 2021. 10.30733/std.2021.01492
ISNAD	AKDAĞ, Turan - Korkmaz, Celalettin. "Diagnostic Values of Clusterin and α-Klotho Levels in Patients with Sarcoidosis". Selçuk Tıp Dergisi 37/1 (2021), 39-44. https://doi.org/10.30733/std.2021.01492