Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9- tetrahydrocannabinol
Yıl: 2021 Cilt: 4 Sayı: 1 Sayfa Aralığı: 50 - 55 Metin Dili: İngilizce DOI: 10.14744/ijmb.2020.83703 İndeks Tarihi: 05-06-2021
Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9- tetrahydrocannabinol
Öz: Objectives: In recent years, cannabinoids have been shown to have beneficial effects on diabetic vascular complications. Vascular complications due to fructose-induced hyperinsulinemia (HI) and diabetic vascular complications havesimilar mechanisms. The aim of this experimental study was to observe whether the cannabinoid agonist delta-9-tetrahydrocannabinol (THC) has an ameliorating effect on fructose-induced HI and vascular responses in the aortic ringof rats with HI.Methods: A total of 24 rats were categorized into 4 groups: control (standard food pellets and water), HI (water containing 10% fructose provided for 12 weeks), THC (1.5 mg/kg/day intraperitoneal administration for 4 weeks), and THC+HI.Body weight was measured again on the last day of the study and the serum insulin level was measured with an enzyme-linked immunosorbent assay. The acetylcholine (ACh) maximum relaxant effect in aortic rings pre-contractedwith noradrenaline (NA) was evaluated.Results: The body weight of THC and THC+HI groups was lower compared with that of the controls (p<0.01). Increasedinsulin level as a result of fructose consumption decreased with THC administration (p<0.01) while the glucose levelincreased in all other groups compared with the control group (p<0.01, p<0.05). The NA Emax value decreased in thegroup receiving THC treatment (p<0.01). The increased ACh pD2 value in the HI groups also decreased in the THCtreatment group (p<0.0001). The decreased maximum inhibition value in the HI group increased significantly with THCadministration (p<0.001).Conclusion: THC demonstrated beneficial effects on fructose-induced HI. THC improved ACh-induced endothelialdependent relaxation in HI rat aortic rings
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| APA | todurga seven z, Gökdemir s, Özyazgan S, KOSE Ç, COSKUN YAZİCİ Z, AKKAN A, Bolkent S (2021). Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9- tetrahydrocannabinol. , 50 - 55. 10.14744/ijmb.2020.83703 |
| Chicago | todurga seven zeynep gizem,Gökdemir selim,Özyazgan Sibel,KOSE ÇAGLA,COSKUN YAZİCİ Zeynep Mine,AKKAN AHMET GÖKHAN,Bolkent Sema Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9- tetrahydrocannabinol. (2021): 50 - 55. 10.14744/ijmb.2020.83703 |
| MLA | todurga seven zeynep gizem,Gökdemir selim,Özyazgan Sibel,KOSE ÇAGLA,COSKUN YAZİCİ Zeynep Mine,AKKAN AHMET GÖKHAN,Bolkent Sema Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9- tetrahydrocannabinol. , 2021, ss.50 - 55. 10.14744/ijmb.2020.83703 |
| AMA | todurga seven z,Gökdemir s,Özyazgan S,KOSE Ç,COSKUN YAZİCİ Z,AKKAN A,Bolkent S Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9- tetrahydrocannabinol. . 2021; 50 - 55. 10.14744/ijmb.2020.83703 |
| Vancouver | todurga seven z,Gökdemir s,Özyazgan S,KOSE Ç,COSKUN YAZİCİ Z,AKKAN A,Bolkent S Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9- tetrahydrocannabinol. . 2021; 50 - 55. 10.14744/ijmb.2020.83703 |
| IEEE | todurga seven z,Gökdemir s,Özyazgan S,KOSE Ç,COSKUN YAZİCİ Z,AKKAN A,Bolkent S "Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9- tetrahydrocannabinol." , ss.50 - 55, 2021. 10.14744/ijmb.2020.83703 |
| ISNAD | todurga seven, zeynep gizem vd. "Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9- tetrahydrocannabinol". (2021), 50-55. https://doi.org/10.14744/ijmb.2020.83703 |
| APA | todurga seven z, Gökdemir s, Özyazgan S, KOSE Ç, COSKUN YAZİCİ Z, AKKAN A, Bolkent S (2021). Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9- tetrahydrocannabinol. International Journal of Medical Biochemistry, 4(1), 50 - 55. 10.14744/ijmb.2020.83703 |
| Chicago | todurga seven zeynep gizem,Gökdemir selim,Özyazgan Sibel,KOSE ÇAGLA,COSKUN YAZİCİ Zeynep Mine,AKKAN AHMET GÖKHAN,Bolkent Sema Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9- tetrahydrocannabinol. International Journal of Medical Biochemistry 4, no.1 (2021): 50 - 55. 10.14744/ijmb.2020.83703 |
| MLA | todurga seven zeynep gizem,Gökdemir selim,Özyazgan Sibel,KOSE ÇAGLA,COSKUN YAZİCİ Zeynep Mine,AKKAN AHMET GÖKHAN,Bolkent Sema Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9- tetrahydrocannabinol. International Journal of Medical Biochemistry, vol.4, no.1, 2021, ss.50 - 55. 10.14744/ijmb.2020.83703 |
| AMA | todurga seven z,Gökdemir s,Özyazgan S,KOSE Ç,COSKUN YAZİCİ Z,AKKAN A,Bolkent S Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9- tetrahydrocannabinol. International Journal of Medical Biochemistry. 2021; 4(1): 50 - 55. 10.14744/ijmb.2020.83703 |
| Vancouver | todurga seven z,Gökdemir s,Özyazgan S,KOSE Ç,COSKUN YAZİCİ Z,AKKAN A,Bolkent S Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9- tetrahydrocannabinol. International Journal of Medical Biochemistry. 2021; 4(1): 50 - 55. 10.14744/ijmb.2020.83703 |
| IEEE | todurga seven z,Gökdemir s,Özyazgan S,KOSE Ç,COSKUN YAZİCİ Z,AKKAN A,Bolkent S "Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9- tetrahydrocannabinol." International Journal of Medical Biochemistry, 4, ss.50 - 55, 2021. 10.14744/ijmb.2020.83703 |
| ISNAD | todurga seven, zeynep gizem vd. "Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9- tetrahydrocannabinol". International Journal of Medical Biochemistry 4/1 (2021), 50-55. https://doi.org/10.14744/ijmb.2020.83703 |
