Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?

sincer, isa; YILMAZ, MÜCAHİD; Çekici, Yusuf; Kaplangoray, Mustafa; Yıldırım, Arafat

doi:10.5455/annalsmedres.2020.05.547

Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?

Yusuf ÇEKİCİ, (Mehmet Akif İnan Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Şanlıurfa, Türkiye)

İsa SİNCER, (Bolu Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Bolu, Türkiye)

Mustafa KAPLANGORAY, (Mehmet Akif İnan Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Şanlıurfa, Türkiye)

Mücahid YILMAZ, (Elazığ Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Elazığ, Türkiye)

Arafat YILDIRIM (Adana Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Adana, Türkiye)

Annals of Medical Research

6 1

Yıl: 2020 Cilt: 27 Sayı: 10 Sayfa Aralığı: 2568 - 2573 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2020.05.547 İndeks Tarihi: 21-05-2021

Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?

Öz:

Aim: Several studies have found a correlation between coronary slow flow (CSF) and low serum high-density lipoprotein cholesterol (HDL-C) levels or high serum uric acid levels. The present study aimed to evaluate whether serum uric acid to HDL-C ratio predicts CSF.Material and Methods: The experimental (CSF) group included 91 patients (40 females, 51 males, mean age: 52±9) who had angiographically normal coronary arteries but had slow flow in one or more coronary arteries. The control group included 96 patients (57 females, 39 males, mean age: 50±9) with normal coronary anatomy and without slow flow. The uric acid to HDL-C ratio was calculated for the two groups and compared.Results: The HDL-C levels of the CSF group (37±8 mg/dL) were significantly lower compared to the controls (49±10 mg/dL, p<0.001), whereas serum uric acid levels (5.33±0.97 mg/dL) and uric acid to HDL-C ratio (0.14±0.03) of the CSF group were significantly higher compared to the controls (4.37±0.88 mg/dL and 0.09±0.02, p<0.001 and p<0.01, respectively).The receiver operating curve (ROC) analysis revealed that a cut-off >4.64 mg/dL uric acidand >0.119 % uric acid to HDL-C ratio had a sensitivity of 81% and 85% and specificity of 76% and 80% for determination of CSF, respectively (AUC=0.850, 95% CI: 0.792 - 0.908 and AUC=0.890, 95% CI: 0.841 - 0.940,respectively).Spearman's correlation test has been performed and a significant positive correlation has been detected between the uric acid to HDL-C ratio and the mean thrombolysis in myocardial infarction (TIMI) frame count (r=0.62, p<0.001).Conclusion: In this study, higher uric acid to HDL-C ratio values of the CSF group was found compared to the control group. Furthermore, uric acid to HDL-C ratio performed better than serum uric acid levels in predicting CSF.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Çekici Y, sincer i, Kaplangoray M, YILMAZ M, Yıldırım A (2020). Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?. , 2568 - 2573. 10.5455/annalsmedres.2020.05.547
Chicago	Çekici Yusuf,sincer isa,Kaplangoray Mustafa,YILMAZ MÜCAHİD,Yıldırım Arafat Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?. (2020): 2568 - 2573. 10.5455/annalsmedres.2020.05.547
MLA	Çekici Yusuf,sincer isa,Kaplangoray Mustafa,YILMAZ MÜCAHİD,Yıldırım Arafat Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?. , 2020, ss.2568 - 2573. 10.5455/annalsmedres.2020.05.547
AMA	Çekici Y,sincer i,Kaplangoray M,YILMAZ M,Yıldırım A Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?. . 2020; 2568 - 2573. 10.5455/annalsmedres.2020.05.547
Vancouver	Çekici Y,sincer i,Kaplangoray M,YILMAZ M,Yıldırım A Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?. . 2020; 2568 - 2573. 10.5455/annalsmedres.2020.05.547
IEEE	Çekici Y,sincer i,Kaplangoray M,YILMAZ M,Yıldırım A "Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?." , ss.2568 - 2573, 2020. 10.5455/annalsmedres.2020.05.547
ISNAD	Çekici, Yusuf vd. "Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?". (2020), 2568-2573. https://doi.org/10.5455/annalsmedres.2020.05.547

APA	Çekici Y, sincer i, Kaplangoray M, YILMAZ M, Yıldırım A (2020). Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?. Annals of Medical Research, 27(10), 2568 - 2573. 10.5455/annalsmedres.2020.05.547
Chicago	Çekici Yusuf,sincer isa,Kaplangoray Mustafa,YILMAZ MÜCAHİD,Yıldırım Arafat Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?. Annals of Medical Research 27, no.10 (2020): 2568 - 2573. 10.5455/annalsmedres.2020.05.547
MLA	Çekici Yusuf,sincer isa,Kaplangoray Mustafa,YILMAZ MÜCAHİD,Yıldırım Arafat Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?. Annals of Medical Research, vol.27, no.10, 2020, ss.2568 - 2573. 10.5455/annalsmedres.2020.05.547
AMA	Çekici Y,sincer i,Kaplangoray M,YILMAZ M,Yıldırım A Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?. Annals of Medical Research. 2020; 27(10): 2568 - 2573. 10.5455/annalsmedres.2020.05.547
Vancouver	Çekici Y,sincer i,Kaplangoray M,YILMAZ M,Yıldırım A Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?. Annals of Medical Research. 2020; 27(10): 2568 - 2573. 10.5455/annalsmedres.2020.05.547
IEEE	Çekici Y,sincer i,Kaplangoray M,YILMAZ M,Yıldırım A "Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?." Annals of Medical Research, 27, ss.2568 - 2573, 2020. 10.5455/annalsmedres.2020.05.547
ISNAD	Çekici, Yusuf vd. "Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?". Annals of Medical Research 27/10 (2020), 2568-2573. https://doi.org/10.5455/annalsmedres.2020.05.547