Imatinib Mesylate Treatment in Chronic Myeloid Leukemia
Yıl: 2020 Cilt: 10 Sayı: 1 Sayfa Aralığı: 107 - 112 Metin Dili: İngilizce DOI: 10.31832/smj.648445 İndeks Tarihi: 23-05-2021
Imatinib Mesylate Treatment in Chronic Myeloid Leukemia
Öz: Objective To evaluate retrospectively the efficacy of treatment in chronic myeloid leukemia (CML) patients followed up in our center and receiving imatinib treatment.Materialsand MethodsEighty-five chronic phase CML patients with adequate clinical and laboratory data were included in this study. Patients received imatinib treatment as a first-line treatment.Results Forty-eight (56.47 %) patients were male, and 37 (43.53 %) of them were female. The median age at diagnosis was 52 years (19-79). The mean follow-up period was 45(12-158) months. In the follow-up, 6 of the chronic phase patients progressed to a blastic and accelerated phase. In the third month of imatinib treatment, 77 (90.59 %)patients had a complete hematologic response, and 85 (100 %) patients had a full hematologic response at 18 months. In our study, cytogenetic data of 78 patients withadequate metaphase (≥ 20) could be evaluated within the first 18 months after the diagnosis was made. At the end of 18 months, 68 (87.18 %) of 78 patients had completecytogenetic response.Conclusions Imatinib is well tolerated and an alternative to other therapies.
Anahtar Kelime: Kronik Miyeloid Lösemide İmatinib Mesilat Tedavisi
Öz: Amaç Merkezimizde takip edilen ve imatinib tedavisi alan kronik miyeloid lösemi (KML) hastalarında tedavinin etkinliğini retrospektif olarak değerlendirmek. Gereç ve Yöntemler Bu vaka kontrol çalışmasına klinik ve laboratuvar verileri tam olan 85 kronik evre KML hastası dahil edildi. Hastalar imatinib tedavisini birinci basamak olarak almışlardır. Bulgular Kırk sekiz (% 56,47) hasta erkek, 37 (% 43,53) hasta kadındı. Tanı sırasındaki hastaların yaşlarının ortancası yaş 52 idi (19-79). Ortalama takip süresi 45 (12-158) aydı. İzlemde kronik faz hastalarının 6’sı blastik ve hızlandırılmış faza ilerlemiştir. İmatinib tedavisinin üçüncü ayında, 77 (% 90,59) hasta tam hematolojik yanıt aldı ve 85 (% 100) hasta 18 ayda tam hematolojik yanıt aldı. Çalışmamızda, uygun metafazlı (≥ 20) 78 hastanın sitogenetik verileri, tanı konulduktan sonraki ilk 18 ay içinde değerlendirildi. 18 ayın sonunda 78 hastanın 68’inde (% 87.18) tam sitogenetik yanıt vardı. Sonuç İmatinib, KML hastaları tarafından iyi tolere edilir ve alternatif bir tedavi yöntemidir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | ÇEKDEMIR D, Gunduz M (2020). Imatinib Mesylate Treatment in Chronic Myeloid Leukemia. , 107 - 112. 10.31832/smj.648445 |
| Chicago | ÇEKDEMIR DEMET,Gunduz Mehmet Imatinib Mesylate Treatment in Chronic Myeloid Leukemia. (2020): 107 - 112. 10.31832/smj.648445 |
| MLA | ÇEKDEMIR DEMET,Gunduz Mehmet Imatinib Mesylate Treatment in Chronic Myeloid Leukemia. , 2020, ss.107 - 112. 10.31832/smj.648445 |
| AMA | ÇEKDEMIR D,Gunduz M Imatinib Mesylate Treatment in Chronic Myeloid Leukemia. . 2020; 107 - 112. 10.31832/smj.648445 |
| Vancouver | ÇEKDEMIR D,Gunduz M Imatinib Mesylate Treatment in Chronic Myeloid Leukemia. . 2020; 107 - 112. 10.31832/smj.648445 |
| IEEE | ÇEKDEMIR D,Gunduz M "Imatinib Mesylate Treatment in Chronic Myeloid Leukemia." , ss.107 - 112, 2020. 10.31832/smj.648445 |
| ISNAD | ÇEKDEMIR, DEMET - Gunduz, Mehmet. "Imatinib Mesylate Treatment in Chronic Myeloid Leukemia". (2020), 107-112. https://doi.org/10.31832/smj.648445 |
| APA | ÇEKDEMIR D, Gunduz M (2020). Imatinib Mesylate Treatment in Chronic Myeloid Leukemia. Sakarya Tıp Dergisi, 10(1), 107 - 112. 10.31832/smj.648445 |
| Chicago | ÇEKDEMIR DEMET,Gunduz Mehmet Imatinib Mesylate Treatment in Chronic Myeloid Leukemia. Sakarya Tıp Dergisi 10, no.1 (2020): 107 - 112. 10.31832/smj.648445 |
| MLA | ÇEKDEMIR DEMET,Gunduz Mehmet Imatinib Mesylate Treatment in Chronic Myeloid Leukemia. Sakarya Tıp Dergisi, vol.10, no.1, 2020, ss.107 - 112. 10.31832/smj.648445 |
| AMA | ÇEKDEMIR D,Gunduz M Imatinib Mesylate Treatment in Chronic Myeloid Leukemia. Sakarya Tıp Dergisi. 2020; 10(1): 107 - 112. 10.31832/smj.648445 |
| Vancouver | ÇEKDEMIR D,Gunduz M Imatinib Mesylate Treatment in Chronic Myeloid Leukemia. Sakarya Tıp Dergisi. 2020; 10(1): 107 - 112. 10.31832/smj.648445 |
| IEEE | ÇEKDEMIR D,Gunduz M "Imatinib Mesylate Treatment in Chronic Myeloid Leukemia." Sakarya Tıp Dergisi, 10, ss.107 - 112, 2020. 10.31832/smj.648445 |
| ISNAD | ÇEKDEMIR, DEMET - Gunduz, Mehmet. "Imatinib Mesylate Treatment in Chronic Myeloid Leukemia". Sakarya Tıp Dergisi 10/1 (2020), 107-112. https://doi.org/10.31832/smj.648445 |
