Impact of Smoking on Clinical Outcomes in ST-Elevated Myocardial Infarction Patients with Small Infarct Related Coronary Vessels
Yıl: 2020 Cilt: 10 Sayı: 1 Sayfa Aralığı: 121 - 127 Metin Dili: İngilizce DOI: 10.31832/smj.637410 İndeks Tarihi: 23-05-2021
Impact of Smoking on Clinical Outcomes in ST-Elevated Myocardial Infarction Patients with Small Infarct Related Coronary Vessels
Öz: Objective The impact of smoking status on clinical outcomes is unknown in ST-segment elevation myocardial infarction (STEMI) patients with small culprit vessel coronary arterydisease (CAD). The aim of this study was to evaluate the in-hospital mortality and long-term outcomes of STEMI patients with small infarct related vessels according tosmoking status.Materialsand MethodsBetween January 2014 and May 2017, 310 consecutive STEMI patients with small infarct related coronary vessel who underwent primary percutaous intervention wereincluded in this retrospective study. The patients were classified into two groups according to status of smoking, as smokers (n =163) and non-smokers (n =147). Theprimary outcome was major adverse cardiac events (MACE). The secondary end-point included in-hospital mortality.Results During the follow-up of 24 months, MACE occurred in 25 (15.70%) patients in smokers and 9 (6.30%) patients in non-smokers (p:0.008). The target-lesion revascularization(TLR), target-vessel revascularization (TVR) and myocardial infarction (MI) rates was found significantly higher in the smoker group as compared with the non-smokergroup (p:0.024, p:0,014, p:0,011, respectively). The rate of in-hospital mortality was found similar between groups (p: 0.869). In multivariate Cox analysis for 2-year MACE,after accounting for all covariables, smoking was associated with increased risk in the small vessel CAD population (HR: 2.60, %95CI: 1.21-5.57). Moreover, smoking wasassociated with a increased TLR (HR: 3.25, %95 CI: 1.07-9.89), TVR (HR: 3.13, %95 CI: 1.15-8.50) and MI (HR: 2.81, %95 CI: 1,19-6,62) risk at 2-years follow up.Conclusions In our real-world registry of patients who underwent primary percutaneous coronary intervention (PPCI), groups had similar in-hospital mortality, but smoking isindependently associated with poorer outcomes during 2-year follow-up.
Anahtar Kelime: İnfarktla İlişkili Küçük Koroner Damarları Olan ST-Yükselmeli Miyokard İnfarktüslü Hastalarda Sigara İçiminin Klinik Sonuçlar Üzerine Etkisi
Öz: Amaç Sigara içme durumunun klinik sonuçlar üzerindeki etkisi, küçük sorumlu damar koroner arter hastalığı (KAH) olan ST segment elevasyonlu miyokard enfarktüsü (STEMI) hastalarında bilinmemektedir. Bu çalışmanın amacı, enfarktüs ile ilişkili küçük damarları olan STEMI hastalarının hastane içi mortalitesini ve uzun dönem sonuçlarını sigara içme durumuna göre değerlendirmektir. Gereç ve Yöntemler Bu retrospektif çalışmaya Ocak 2014 ve Mayıs 2017 tarihleri arasında primer perkütan girişim geçiren, enfarktüs ile ilişkili küçük koroner damarı bulunan 310 ardışık STEMI hastası alındı. Hastalar sigara içme durumuna göre sigara kullananlar (n = 163) ve sigara kullanmayanlar (n = 147) olmak üzere iki gruba ayrıldı. Birincil sonlanım majör advers kardiyak olaylardı (MACE). Sekonder sonlanım noktası hastane içi mortaliteyi içeriyordu. Bulgular 24 aylık takipte sigara içenlerde 25 (%15,34) hastada, sigara içmeyenlerde 9 (%6,12) hastada MOKO gelişti (p:0,008). Sigara içen grupta hedef lezyon revaskülarizasyonu (HLR), hedef damar revaskülarizasyonu (HDR) ve miyokard infarktüsü (MI) oranları sigara içmeyenlere göre anlamlı derecede yüksek bulundu (sırasıyla, p:0.024, p:0,014, p:0,011). Hastane içi mortalite oranı iki grup arasında benzer bulundu (p: 0.869). 2 yıllık MOKO için çok değişkenli Cox analizinde, tüm değişkenler için hesap yapıldıktan sonra, sigara kullanımı, küçük damar KAH popülasyonunda artmış risk ile ilişkili bulunmuştur (HR: 2.60, %95 CI: 1.21-5.57). Ayrıca sigara içilmesi 2 yıllık takipte, HLR (HR: 3.25, %95 CI: 1.07-9.89), HDR (HR: 3.13, %95 CI: 1.15-8.50) ve MI (HR: 2.81, %95 CI: 1,19-6,62) için daha yüksek bir risk ile ilişkilendirildi. Sonuç Gerçek yaşam kayıt çalışmamızda primer perkutan koroner girişim (PPKG) yapılan küçük damar KAH olan hastalarda hastane içi ölüm oranları gruplar arasında benzer saptandı, ancak 2 yıllık takipte sigara kullanımı kötü sonlanımlar ile bağımsız ilişkili bulundu.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | COŞANSU K, ÜREYEN Ç (2020). Impact of Smoking on Clinical Outcomes in ST-Elevated Myocardial Infarction Patients with Small Infarct Related Coronary Vessels. , 121 - 127. 10.31832/smj.637410 |
| Chicago | COŞANSU KAHRAMAN,ÜREYEN Çağın Mustafa Impact of Smoking on Clinical Outcomes in ST-Elevated Myocardial Infarction Patients with Small Infarct Related Coronary Vessels. (2020): 121 - 127. 10.31832/smj.637410 |
| MLA | COŞANSU KAHRAMAN,ÜREYEN Çağın Mustafa Impact of Smoking on Clinical Outcomes in ST-Elevated Myocardial Infarction Patients with Small Infarct Related Coronary Vessels. , 2020, ss.121 - 127. 10.31832/smj.637410 |
| AMA | COŞANSU K,ÜREYEN Ç Impact of Smoking on Clinical Outcomes in ST-Elevated Myocardial Infarction Patients with Small Infarct Related Coronary Vessels. . 2020; 121 - 127. 10.31832/smj.637410 |
| Vancouver | COŞANSU K,ÜREYEN Ç Impact of Smoking on Clinical Outcomes in ST-Elevated Myocardial Infarction Patients with Small Infarct Related Coronary Vessels. . 2020; 121 - 127. 10.31832/smj.637410 |
| IEEE | COŞANSU K,ÜREYEN Ç "Impact of Smoking on Clinical Outcomes in ST-Elevated Myocardial Infarction Patients with Small Infarct Related Coronary Vessels." , ss.121 - 127, 2020. 10.31832/smj.637410 |
| ISNAD | COŞANSU, KAHRAMAN - ÜREYEN, Çağın Mustafa. "Impact of Smoking on Clinical Outcomes in ST-Elevated Myocardial Infarction Patients with Small Infarct Related Coronary Vessels". (2020), 121-127. https://doi.org/10.31832/smj.637410 |
| APA | COŞANSU K, ÜREYEN Ç (2020). Impact of Smoking on Clinical Outcomes in ST-Elevated Myocardial Infarction Patients with Small Infarct Related Coronary Vessels. Sakarya Tıp Dergisi, 10(1), 121 - 127. 10.31832/smj.637410 |
| Chicago | COŞANSU KAHRAMAN,ÜREYEN Çağın Mustafa Impact of Smoking on Clinical Outcomes in ST-Elevated Myocardial Infarction Patients with Small Infarct Related Coronary Vessels. Sakarya Tıp Dergisi 10, no.1 (2020): 121 - 127. 10.31832/smj.637410 |
| MLA | COŞANSU KAHRAMAN,ÜREYEN Çağın Mustafa Impact of Smoking on Clinical Outcomes in ST-Elevated Myocardial Infarction Patients with Small Infarct Related Coronary Vessels. Sakarya Tıp Dergisi, vol.10, no.1, 2020, ss.121 - 127. 10.31832/smj.637410 |
| AMA | COŞANSU K,ÜREYEN Ç Impact of Smoking on Clinical Outcomes in ST-Elevated Myocardial Infarction Patients with Small Infarct Related Coronary Vessels. Sakarya Tıp Dergisi. 2020; 10(1): 121 - 127. 10.31832/smj.637410 |
| Vancouver | COŞANSU K,ÜREYEN Ç Impact of Smoking on Clinical Outcomes in ST-Elevated Myocardial Infarction Patients with Small Infarct Related Coronary Vessels. Sakarya Tıp Dergisi. 2020; 10(1): 121 - 127. 10.31832/smj.637410 |
| IEEE | COŞANSU K,ÜREYEN Ç "Impact of Smoking on Clinical Outcomes in ST-Elevated Myocardial Infarction Patients with Small Infarct Related Coronary Vessels." Sakarya Tıp Dergisi, 10, ss.121 - 127, 2020. 10.31832/smj.637410 |
| ISNAD | COŞANSU, KAHRAMAN - ÜREYEN, Çağın Mustafa. "Impact of Smoking on Clinical Outcomes in ST-Elevated Myocardial Infarction Patients with Small Infarct Related Coronary Vessels". Sakarya Tıp Dergisi 10/1 (2020), 121-127. https://doi.org/10.31832/smj.637410 |
