Yıl: 2019 Cilt: 21 Sayı: 1 Sayfa Aralığı: 73 - 79 Metin Dili: İngilizce DOI: 10.24938/kutfd.522955 İndeks Tarihi: 25-05-2021

PLATELET TO LYMPHOCYTE RATIO AS A PREDICTIVE BIOMARKER FOR PREOPERATIVE DIAGNOSIS OF PARATHYROID ADENOMA

Öz:
Objective: There is a significant increase in studies concerningthe use of platelet to lymphocyte ratio (PLR) and neutrophil tolymphocyte ratio (NLR) for diagnosis and prognosis in manyinflammatory and malignant diseases. The idea that PLR andNLR can be used as a biomarker attracts many researchers tothis area. The aim of this retrospective case control study was toinvestigate the role of PLR and NLR values in diagnosis of theparathyroid adenoma.Material and Methods: In this study, 17 patients withparathyroid adenoma (PAD group) were included and the PLRand NLR values of these patients were compared with controlgroup (15 participants) consisted of healthy subjects.Results: The lymphocyte count values of the PAD group weresignificantly higher than those of the CONTROL group. Theplatelet count and NLR values were not different between thegroups. The PLR values of the PAD group were significantlylower than those of the CONTROL groups. ROC-Curve analysisresults showed that if platelet to lymphocyte ratio value was<125, it could be a specific and sensitive biomarker indiscrimination of patients with parathyroid adenoma fromhealthy individuals.Conclusion: In conclusion, low PLR values measured inpatients with primary hyperparathyroidism could be a newpreoperative diagnostic biomarker for parathyroid adenoma.
Anahtar Kelime:

Paratiroid Adenomunun Ameliyat Öncesi Tanısında Öngörücü Bir Biyobelirteç Olarak Trombosit/Lenfosit Oranı

Öz:
Amaç: Trombosit lenfosit oranı (PLR) ve nötrofilin lenfosit oranı (NLR) değerlerinin pekçok inflamatuvar ve malign hastalığın prognoz ve tanısında kullanımına yönelik çalışmalar her geçen gün artarak devam etmektedir. PLR ve NLR nin bir biyobelirteç olarak kullanılabilirliği fikri pek çok araştırmacının ilgisini bu alana çekmektedir. Bu retrospektif vaka kontrol çalışmasının amacı, PLR ve NLR değerlerinin paratiroid adenomu tanısındaki rolünü araştırmaktır. Gereç ve Yöntemler: Bu çalışmaya paratiroid adenomu olan 17 hasta (PAD grubu) dahil edildi ve bu hastalara ait PLR ve NLR değerleri sağlıklı bireylerden oluşan Kontrol grubu (15 katılımcı) değerleri ile karşılaştırıldı. Bulgular: PAD grubunun lenfosit sayım değerleri CONTROL grubundan anlamlı derecede yüksekti. Trombosit sayısı ve NLR değerleri gruplar arasında farklı değildi. PAD grubunun PLR değerleri Kontrol grubundakilerden anlamlı derecede düşüktü. ROC-Curve analizi sonuçları, trombosit lenfosit oranı değeri <125 olduğunda, paratiroid adenomlu hastaların sağlıklı bireylerden ayrılmasında spesifik ve hassas bir biyobelirteç olabileceğini göstermiştir. Sonuç: Sonuç olarak, primer hiperparatiroidizm hastalarında ölçülen düşük trombosit lenfosit oranı değerleri paratiroid adenomu tanısı için preoperatif yeni bir biyobelirteç olabilir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Aydın O, PEHLIVANLI F (2019). PLATELET TO LYMPHOCYTE RATIO AS A PREDICTIVE BIOMARKER FOR PREOPERATIVE DIAGNOSIS OF PARATHYROID ADENOMA. , 73 - 79. 10.24938/kutfd.522955
Chicago Aydın Oktay,PEHLIVANLI FARUK PLATELET TO LYMPHOCYTE RATIO AS A PREDICTIVE BIOMARKER FOR PREOPERATIVE DIAGNOSIS OF PARATHYROID ADENOMA. (2019): 73 - 79. 10.24938/kutfd.522955
MLA Aydın Oktay,PEHLIVANLI FARUK PLATELET TO LYMPHOCYTE RATIO AS A PREDICTIVE BIOMARKER FOR PREOPERATIVE DIAGNOSIS OF PARATHYROID ADENOMA. , 2019, ss.73 - 79. 10.24938/kutfd.522955
AMA Aydın O,PEHLIVANLI F PLATELET TO LYMPHOCYTE RATIO AS A PREDICTIVE BIOMARKER FOR PREOPERATIVE DIAGNOSIS OF PARATHYROID ADENOMA. . 2019; 73 - 79. 10.24938/kutfd.522955
Vancouver Aydın O,PEHLIVANLI F PLATELET TO LYMPHOCYTE RATIO AS A PREDICTIVE BIOMARKER FOR PREOPERATIVE DIAGNOSIS OF PARATHYROID ADENOMA. . 2019; 73 - 79. 10.24938/kutfd.522955
IEEE Aydın O,PEHLIVANLI F "PLATELET TO LYMPHOCYTE RATIO AS A PREDICTIVE BIOMARKER FOR PREOPERATIVE DIAGNOSIS OF PARATHYROID ADENOMA." , ss.73 - 79, 2019. 10.24938/kutfd.522955
ISNAD Aydın, Oktay - PEHLIVANLI, FARUK. "PLATELET TO LYMPHOCYTE RATIO AS A PREDICTIVE BIOMARKER FOR PREOPERATIVE DIAGNOSIS OF PARATHYROID ADENOMA". (2019), 73-79. https://doi.org/10.24938/kutfd.522955
APA Aydın O, PEHLIVANLI F (2019). PLATELET TO LYMPHOCYTE RATIO AS A PREDICTIVE BIOMARKER FOR PREOPERATIVE DIAGNOSIS OF PARATHYROID ADENOMA. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi, 21(1), 73 - 79. 10.24938/kutfd.522955
Chicago Aydın Oktay,PEHLIVANLI FARUK PLATELET TO LYMPHOCYTE RATIO AS A PREDICTIVE BIOMARKER FOR PREOPERATIVE DIAGNOSIS OF PARATHYROID ADENOMA. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi 21, no.1 (2019): 73 - 79. 10.24938/kutfd.522955
MLA Aydın Oktay,PEHLIVANLI FARUK PLATELET TO LYMPHOCYTE RATIO AS A PREDICTIVE BIOMARKER FOR PREOPERATIVE DIAGNOSIS OF PARATHYROID ADENOMA. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi, vol.21, no.1, 2019, ss.73 - 79. 10.24938/kutfd.522955
AMA Aydın O,PEHLIVANLI F PLATELET TO LYMPHOCYTE RATIO AS A PREDICTIVE BIOMARKER FOR PREOPERATIVE DIAGNOSIS OF PARATHYROID ADENOMA. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi. 2019; 21(1): 73 - 79. 10.24938/kutfd.522955
Vancouver Aydın O,PEHLIVANLI F PLATELET TO LYMPHOCYTE RATIO AS A PREDICTIVE BIOMARKER FOR PREOPERATIVE DIAGNOSIS OF PARATHYROID ADENOMA. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi. 2019; 21(1): 73 - 79. 10.24938/kutfd.522955
IEEE Aydın O,PEHLIVANLI F "PLATELET TO LYMPHOCYTE RATIO AS A PREDICTIVE BIOMARKER FOR PREOPERATIVE DIAGNOSIS OF PARATHYROID ADENOMA." Kırıkkale Üniversitesi Tıp Fakültesi Dergisi, 21, ss.73 - 79, 2019. 10.24938/kutfd.522955
ISNAD Aydın, Oktay - PEHLIVANLI, FARUK. "PLATELET TO LYMPHOCYTE RATIO AS A PREDICTIVE BIOMARKER FOR PREOPERATIVE DIAGNOSIS OF PARATHYROID ADENOMA". Kırıkkale Üniversitesi Tıp Fakültesi Dergisi 21/1 (2019), 73-79. https://doi.org/10.24938/kutfd.522955