Effect of Strontium Ranelate on Condylar Growthduring Mandibular Advancement in Rats
Yıl: 2020 Cilt: 33 Sayı: 4 Sayfa Aralığı: 216 - 223 Metin Dili: İngilizce DOI: 10.5152/TurkJOrthod.2020.20014 İndeks Tarihi: 31-05-2021
Effect of Strontium Ranelate on Condylar Growthduring Mandibular Advancement in Rats
Öz: Objective: Strontium ranelate (SR), unlike other anti-osteoporotic agents, might not only prevent bone resorption but also might induce bone formation. The aim of this experimental study was to evaluate the effects of systemic SR on condylar growth during mandibular advancement (MA) in growing rats.Methods: Fifty-six, 8-week-old Wistar male rats weighting 160-190 g were randomly divided into four groups; one control (n=14) and three experimental (n=14). Group 1: Control group, Group 2: SR (900mg/kg daily dose), Group 3: MA, Group 4: SR +MA. The amount and direction of mandibular growth were assessed by linear measurements on the computed tomography (CT) images taken on days 1, 15, and 30. For immunohistochemical evaluation, half of the subjects in the groups were sacrificed on the 15th day (early phase) and the rest of them on the 30th day (late phase). New cartilage and bone formation areas on the condyle were analyzed by using Sox9 and Osteopontin antibodies.Results: Early and late CT images measurements showed no significant difference between the groups (p<0.05). However, there were significant differences between the control and experimental groups in the immunohistochemical assessment. Severe immunolocalization of SOX9 and Osteopontin was observed in Group 4, while the immunolocalization scores were moderate in Group 2 and Group 3. In addition, early histological findings were similar to late results in all groups.Conclusion: In mandibular advancement therapy, Strontium ranelate could be therapeutically effective in avoiding relapse and reducing the duration of retention
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | CAMCI H, doruk e, ÜNVER SARAYDIN S (2020). Effect of Strontium Ranelate on Condylar Growthduring Mandibular Advancement in Rats. , 216 - 223. 10.5152/TurkJOrthod.2020.20014 |
| Chicago | CAMCI HASAN,doruk ercan cenk,ÜNVER SARAYDIN Serpil Effect of Strontium Ranelate on Condylar Growthduring Mandibular Advancement in Rats. (2020): 216 - 223. 10.5152/TurkJOrthod.2020.20014 |
| MLA | CAMCI HASAN,doruk ercan cenk,ÜNVER SARAYDIN Serpil Effect of Strontium Ranelate on Condylar Growthduring Mandibular Advancement in Rats. , 2020, ss.216 - 223. 10.5152/TurkJOrthod.2020.20014 |
| AMA | CAMCI H,doruk e,ÜNVER SARAYDIN S Effect of Strontium Ranelate on Condylar Growthduring Mandibular Advancement in Rats. . 2020; 216 - 223. 10.5152/TurkJOrthod.2020.20014 |
| Vancouver | CAMCI H,doruk e,ÜNVER SARAYDIN S Effect of Strontium Ranelate on Condylar Growthduring Mandibular Advancement in Rats. . 2020; 216 - 223. 10.5152/TurkJOrthod.2020.20014 |
| IEEE | CAMCI H,doruk e,ÜNVER SARAYDIN S "Effect of Strontium Ranelate on Condylar Growthduring Mandibular Advancement in Rats." , ss.216 - 223, 2020. 10.5152/TurkJOrthod.2020.20014 |
| ISNAD | CAMCI, HASAN vd. "Effect of Strontium Ranelate on Condylar Growthduring Mandibular Advancement in Rats". (2020), 216-223. https://doi.org/10.5152/TurkJOrthod.2020.20014 |
| APA | CAMCI H, doruk e, ÜNVER SARAYDIN S (2020). Effect of Strontium Ranelate on Condylar Growthduring Mandibular Advancement in Rats. Turkish Journal of Orthodontics, 33(4), 216 - 223. 10.5152/TurkJOrthod.2020.20014 |
| Chicago | CAMCI HASAN,doruk ercan cenk,ÜNVER SARAYDIN Serpil Effect of Strontium Ranelate on Condylar Growthduring Mandibular Advancement in Rats. Turkish Journal of Orthodontics 33, no.4 (2020): 216 - 223. 10.5152/TurkJOrthod.2020.20014 |
| MLA | CAMCI HASAN,doruk ercan cenk,ÜNVER SARAYDIN Serpil Effect of Strontium Ranelate on Condylar Growthduring Mandibular Advancement in Rats. Turkish Journal of Orthodontics, vol.33, no.4, 2020, ss.216 - 223. 10.5152/TurkJOrthod.2020.20014 |
| AMA | CAMCI H,doruk e,ÜNVER SARAYDIN S Effect of Strontium Ranelate on Condylar Growthduring Mandibular Advancement in Rats. Turkish Journal of Orthodontics. 2020; 33(4): 216 - 223. 10.5152/TurkJOrthod.2020.20014 |
| Vancouver | CAMCI H,doruk e,ÜNVER SARAYDIN S Effect of Strontium Ranelate on Condylar Growthduring Mandibular Advancement in Rats. Turkish Journal of Orthodontics. 2020; 33(4): 216 - 223. 10.5152/TurkJOrthod.2020.20014 |
| IEEE | CAMCI H,doruk e,ÜNVER SARAYDIN S "Effect of Strontium Ranelate on Condylar Growthduring Mandibular Advancement in Rats." Turkish Journal of Orthodontics, 33, ss.216 - 223, 2020. 10.5152/TurkJOrthod.2020.20014 |
| ISNAD | CAMCI, HASAN vd. "Effect of Strontium Ranelate on Condylar Growthduring Mandibular Advancement in Rats". Turkish Journal of Orthodontics 33/4 (2020), 216-223. https://doi.org/10.5152/TurkJOrthod.2020.20014 |
