Unexpected Histopathological Diagnoses in Acute Appendicitis Specimens: A Retrospective Analysis of 2076 Patients
Yıl: 2020 Cilt: 30 Sayı: 3 Sayfa Aralığı: 151 - 156 Metin Dili: İngilizce DOI: 10.4274/tjcd.galenos.2020.2020-3-1 İndeks Tarihi: 31-05-2021
Unexpected Histopathological Diagnoses in Acute Appendicitis Specimens: A Retrospective Analysis of 2076 Patients
Öz: Aim: Acute appendicitis is the most common cause of emergency abdominal surgery in the world. Although the etiology of appendicitis is still notfully known, possible causes include lumen obstruction. Fecaloid and lymphoid hyperplasia are the most common causes of lumen obstruction.However, some rare conditions may cause acute appendicitis by causing lumen obstruction. Here, we aimed to present the pathology results of 2076patients operated due to acute appendicitis in our hospital and the unexpected histopathological findings in the light of the literature.Method: Patients who were emergently operated with diagnosis of appendicitis between January 2016 and February 2020 in Gaziantep Dr. ErsinArslan Training and Research Hospital were retrospectively screened. Incidental appendectomies were excluded. Data of 2076 patients were reached.Gender, age, and pathology results of the patients were analyzed. Pathology preparations were reassessed by two pathologists. Pathology results wereanalyzed under two categories as general findings and unexpected findings. Fisher’s chi-square test was used for statistical analysis.Results: A total of 2076 patients were included in the study and analyzed. Of the patients, 1368 (66%) were man, 708 (34%) were woman, and themean age was 33±12.9 years. Acute appendicitis was found in 1309 (63.1%) patients, gangrenous-perforated appendicitis in 305 (14.7%) patients,negative appendectomy in 105 (5.1%) patients, phlegmonous appendicitis in 32 (1.5%) patients, and unexpected pathological findings in 62 (3%)patients. Among the unexpected pathological findings were fibrous obliteration in 31 (50%) patients, mucosal hyperplasia in 8 (13%) patients,appendicular diverticulitis in 7 (11.3%) patients, retention cyst in 5 (8.1%) patients, mucinous cystadenoma in 3 (4.8%) patients, well-differentiatedneuroendocrine tumor in 2 (3.2%) patients, eosinophilic infiltration in 2 (3.2%) patients, foreign body reaction in 2 (3.2%) patients, granulomatousappendicitis in 1 (1.6%) patient, and parasitic infestation was detected in 1 (1.6%) patient.Conclusion: Unexpected histopathological findings are rare in appendectomy specimens and these diagnoses help guide the patient’s treatment.
Anahtar Kelime: Akut Apandisit Spesmenlerinde Beklenmeyen Histopatolojik Tanılar: 2076 Hastanın Retrospektif Analizi
Öz: Amaç: Akut apandisit dünya üzerinde en sık acil karın ameliyatıdır. Apandisitin etiyolojisi hala tam olarak bilinmemekle birlikte olası nedenler arasında lümen obstrüksiyonu yer alır. Fekaloit ve lenfoid hiperplazi lümen obstrüksiyonuna neden olan en yaygın nedenlerdir. Ancak bazı nadir durumlar da lümen obstrüksiyonu yaparak akut apandisite neden olabilmektedir. Biz burada hastanemizde akut apandisit tanısıyla opere edilen 2076 hastanın patoloji sonuçlarını ve bunlar arasında beklenmeyen histopatolojik bulguları literatür eşliğinde sunmayı amaçladık. Yöntem: Gaziantep Dr. Ersin Arslan Eğitim ve Araştırma Hastanesi’nde Ocak 2016-Şubat 2020 tarihleri arasında akut apandisit tanısıyla acil opere edilen hastalar retrospektif olarak tarandı. İnsidental apendektomiler çalışma dışı bırakıldı. Toplam 2076 hastanın verisine ulaşıldı. Hastaların cinsiyet, yaş ve patoloji sonuçları analiz edildi. Patoloji preparatları iki patolog tarafından tekrar değerlendirildi. Patoloji sonuçları genel bulgular ve beklenmeyen bulgular olarak iki kategori altında incelendi. İstatistiksel analizde Fisher’s ki-kare testi kullanıldı. Bulgular: Toplam 2076 hasta çalışmaya dahil edilip analiz edildi. Bu hastalar 1368 (%66) erkek olup, toplam yaş ortalaması 33±12,9 idi. Akut apandisit 1309 (%63,1), gangrenöz-perfore apandisit 305 (%14,7), negatif apendektomi 105 (%5,1), flegmanöz apandisit 32 (%1,5), beklenmeyen patolojik bulgular ise 62 (%3) hastada saptandı. Beklenmeyen patolojik bulgular içerisinde, 31 (%50) hastada fibröz obliterasyon 8 (%13) hastada mukozal hiperplazi, 7 (%11,3) hastada apendiküler divertikülit, 5 (%8,1) hastada retansiyon kisti 3 (%4,8) hastada müsinöz kistadenom 2 (%3,2) hastada iyi defansiye nöroendokrin tümör, 2 (%3,2) hastada eozinofilik infiltrasyon, 2 (%3,2) hastada yabancı cisim reaksiyonu, 1 (%1,6) hastada granülomatöz apandisit ve 1 (%1,6) hastada parazit enfestasyonu saptandı. Sonuç: Apendektomi spesmenlerinde beklenmedik histopatolojik bulgular nadir olup, bu tanılar hastanın tedavisini yönlendirmeye yardımcı olmaktadırlar.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Uylas U, Gündoğdu R, Gemici K, TSAPLİNA M, Ayerden D (2020). Unexpected Histopathological Diagnoses in Acute Appendicitis Specimens: A Retrospective Analysis of 2076 Patients. , 151 - 156. 10.4274/tjcd.galenos.2020.2020-3-1 |
| Chicago | Uylas Ufuk,Gündoğdu Ramazan,Gemici Kazım,TSAPLİNA Marina,Ayerden Dila Unexpected Histopathological Diagnoses in Acute Appendicitis Specimens: A Retrospective Analysis of 2076 Patients. (2020): 151 - 156. 10.4274/tjcd.galenos.2020.2020-3-1 |
| MLA | Uylas Ufuk,Gündoğdu Ramazan,Gemici Kazım,TSAPLİNA Marina,Ayerden Dila Unexpected Histopathological Diagnoses in Acute Appendicitis Specimens: A Retrospective Analysis of 2076 Patients. , 2020, ss.151 - 156. 10.4274/tjcd.galenos.2020.2020-3-1 |
| AMA | Uylas U,Gündoğdu R,Gemici K,TSAPLİNA M,Ayerden D Unexpected Histopathological Diagnoses in Acute Appendicitis Specimens: A Retrospective Analysis of 2076 Patients. . 2020; 151 - 156. 10.4274/tjcd.galenos.2020.2020-3-1 |
| Vancouver | Uylas U,Gündoğdu R,Gemici K,TSAPLİNA M,Ayerden D Unexpected Histopathological Diagnoses in Acute Appendicitis Specimens: A Retrospective Analysis of 2076 Patients. . 2020; 151 - 156. 10.4274/tjcd.galenos.2020.2020-3-1 |
| IEEE | Uylas U,Gündoğdu R,Gemici K,TSAPLİNA M,Ayerden D "Unexpected Histopathological Diagnoses in Acute Appendicitis Specimens: A Retrospective Analysis of 2076 Patients." , ss.151 - 156, 2020. 10.4274/tjcd.galenos.2020.2020-3-1 |
| ISNAD | Uylas, Ufuk vd. "Unexpected Histopathological Diagnoses in Acute Appendicitis Specimens: A Retrospective Analysis of 2076 Patients". (2020), 151-156. https://doi.org/10.4274/tjcd.galenos.2020.2020-3-1 |
| APA | Uylas U, Gündoğdu R, Gemici K, TSAPLİNA M, Ayerden D (2020). Unexpected Histopathological Diagnoses in Acute Appendicitis Specimens: A Retrospective Analysis of 2076 Patients. Türk Kolon ve Rektum Hastalıkları Dergisi, 30(3), 151 - 156. 10.4274/tjcd.galenos.2020.2020-3-1 |
| Chicago | Uylas Ufuk,Gündoğdu Ramazan,Gemici Kazım,TSAPLİNA Marina,Ayerden Dila Unexpected Histopathological Diagnoses in Acute Appendicitis Specimens: A Retrospective Analysis of 2076 Patients. Türk Kolon ve Rektum Hastalıkları Dergisi 30, no.3 (2020): 151 - 156. 10.4274/tjcd.galenos.2020.2020-3-1 |
| MLA | Uylas Ufuk,Gündoğdu Ramazan,Gemici Kazım,TSAPLİNA Marina,Ayerden Dila Unexpected Histopathological Diagnoses in Acute Appendicitis Specimens: A Retrospective Analysis of 2076 Patients. Türk Kolon ve Rektum Hastalıkları Dergisi, vol.30, no.3, 2020, ss.151 - 156. 10.4274/tjcd.galenos.2020.2020-3-1 |
| AMA | Uylas U,Gündoğdu R,Gemici K,TSAPLİNA M,Ayerden D Unexpected Histopathological Diagnoses in Acute Appendicitis Specimens: A Retrospective Analysis of 2076 Patients. Türk Kolon ve Rektum Hastalıkları Dergisi. 2020; 30(3): 151 - 156. 10.4274/tjcd.galenos.2020.2020-3-1 |
| Vancouver | Uylas U,Gündoğdu R,Gemici K,TSAPLİNA M,Ayerden D Unexpected Histopathological Diagnoses in Acute Appendicitis Specimens: A Retrospective Analysis of 2076 Patients. Türk Kolon ve Rektum Hastalıkları Dergisi. 2020; 30(3): 151 - 156. 10.4274/tjcd.galenos.2020.2020-3-1 |
| IEEE | Uylas U,Gündoğdu R,Gemici K,TSAPLİNA M,Ayerden D "Unexpected Histopathological Diagnoses in Acute Appendicitis Specimens: A Retrospective Analysis of 2076 Patients." Türk Kolon ve Rektum Hastalıkları Dergisi, 30, ss.151 - 156, 2020. 10.4274/tjcd.galenos.2020.2020-3-1 |
| ISNAD | Uylas, Ufuk vd. "Unexpected Histopathological Diagnoses in Acute Appendicitis Specimens: A Retrospective Analysis of 2076 Patients". Türk Kolon ve Rektum Hastalıkları Dergisi 30/3 (2020), 151-156. https://doi.org/10.4274/tjcd.galenos.2020.2020-3-1 |
