Artificial sweeteners elicit oxidative stress in rat brain and development of microcytic anemia: Promising protective effects of vitamin C

Mitrasinovic-Brulic, Maja; Suljevic, Damir; Fehratović, Emir; Ibragic, Saida

doi:10.29228/jrp.2

Artificial sweeteners elicit oxidative stress in rat brain and development of microcytic anemia: Promising protective effects of vitamin C

Saida IBRAGI, (University of Sarajevo, Faculty of Science, Department of Chemistry, Sarajevo, Bosnia and Herzegovina)

Emir FEHRATOVI, (University of Sarajevo, Faculty of Science, Department of Biology, Sarajevo, Bosnia and Herzegovina)

Damir SULJEVI, (University of Sarajevo, Faculty of Science, Department of Biology, Sarajevo, Bosnia and Herzegovina)

Maja MITRA INOVI BRULI (University of Sarajevo, Faculty of Science, Department of Biology, Sarajevo, Bosnia and Herzegovina)

Journal of research in pharmacy (online)

4 0

Yıl: 2021 Cilt: 25 Sayı: 2 Sayfa Aralığı: 117 - 123 Metin Dili: İngilizce DOI: 10.29228/jrp.2 İndeks Tarihi: 31-05-2021

Artificial sweeteners elicit oxidative stress in rat brain and development of microcytic anemia: Promising protective effects of vitamin C

Öz:

The aim of this study was to evaluate the effects of sodium cyclamate and saccharine combination on the overall hematological parameters and brain catalase activity in Wistar rats. During a period of 8 weeks, the animals were given the artificial sweeteners in a low (L; 15,4 mg/mL)and high dose (H; 22 mg/mL). Additionally, to determine whether vitamin C can attenuate the changes induced by high doses, it was administered to a third group of animals (H + vit C; 22 mg/mL+25 mg/mL). Decreased hematocrit and hemoglobin values, low erythrocyte count and mean cell volume in the groups treated with the artificial sweeteners were the main hematological changes causing microcytic anemia. Catalase activity in brain tissue decreased with the increase of the sweeteners dose, which clearly indicates the induction of oxidative stress. Further on, catalase was significantly increased in the H + vit C group compared to the H group but there was no significant difference compared to controls. Collectively, these results suggest that sodium cyclamate and saccharine induced considerable alterations in the hematology, an increased consumption of catalase and a high efficiency of vitamin C to ameliorate the oxidative stress.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Ibragic S, Fehratović E, Suljevic D, Mitrasinovic-Brulic M (2021). Artificial sweeteners elicit oxidative stress in rat brain and development of microcytic anemia: Promising protective effects of vitamin C. , 117 - 123. 10.29228/jrp.2
Chicago	Ibragic Saida,Fehratović Emir,Suljevic Damir,Mitrasinovic-Brulic Maja Artificial sweeteners elicit oxidative stress in rat brain and development of microcytic anemia: Promising protective effects of vitamin C. (2021): 117 - 123. 10.29228/jrp.2
MLA	Ibragic Saida,Fehratović Emir,Suljevic Damir,Mitrasinovic-Brulic Maja Artificial sweeteners elicit oxidative stress in rat brain and development of microcytic anemia: Promising protective effects of vitamin C. , 2021, ss.117 - 123. 10.29228/jrp.2
AMA	Ibragic S,Fehratović E,Suljevic D,Mitrasinovic-Brulic M Artificial sweeteners elicit oxidative stress in rat brain and development of microcytic anemia: Promising protective effects of vitamin C. . 2021; 117 - 123. 10.29228/jrp.2
Vancouver	Ibragic S,Fehratović E,Suljevic D,Mitrasinovic-Brulic M Artificial sweeteners elicit oxidative stress in rat brain and development of microcytic anemia: Promising protective effects of vitamin C. . 2021; 117 - 123. 10.29228/jrp.2
IEEE	Ibragic S,Fehratović E,Suljevic D,Mitrasinovic-Brulic M "Artificial sweeteners elicit oxidative stress in rat brain and development of microcytic anemia: Promising protective effects of vitamin C." , ss.117 - 123, 2021. 10.29228/jrp.2
ISNAD	Ibragic, Saida vd. "Artificial sweeteners elicit oxidative stress in rat brain and development of microcytic anemia: Promising protective effects of vitamin C". (2021), 117-123. https://doi.org/10.29228/jrp.2

APA	Ibragic S, Fehratović E, Suljevic D, Mitrasinovic-Brulic M (2021). Artificial sweeteners elicit oxidative stress in rat brain and development of microcytic anemia: Promising protective effects of vitamin C. Journal of research in pharmacy (online), 25(2), 117 - 123. 10.29228/jrp.2
Chicago	Ibragic Saida,Fehratović Emir,Suljevic Damir,Mitrasinovic-Brulic Maja Artificial sweeteners elicit oxidative stress in rat brain and development of microcytic anemia: Promising protective effects of vitamin C. Journal of research in pharmacy (online) 25, no.2 (2021): 117 - 123. 10.29228/jrp.2
MLA	Ibragic Saida,Fehratović Emir,Suljevic Damir,Mitrasinovic-Brulic Maja Artificial sweeteners elicit oxidative stress in rat brain and development of microcytic anemia: Promising protective effects of vitamin C. Journal of research in pharmacy (online), vol.25, no.2, 2021, ss.117 - 123. 10.29228/jrp.2
AMA	Ibragic S,Fehratović E,Suljevic D,Mitrasinovic-Brulic M Artificial sweeteners elicit oxidative stress in rat brain and development of microcytic anemia: Promising protective effects of vitamin C. Journal of research in pharmacy (online). 2021; 25(2): 117 - 123. 10.29228/jrp.2
Vancouver	Ibragic S,Fehratović E,Suljevic D,Mitrasinovic-Brulic M Artificial sweeteners elicit oxidative stress in rat brain and development of microcytic anemia: Promising protective effects of vitamin C. Journal of research in pharmacy (online). 2021; 25(2): 117 - 123. 10.29228/jrp.2
IEEE	Ibragic S,Fehratović E,Suljevic D,Mitrasinovic-Brulic M "Artificial sweeteners elicit oxidative stress in rat brain and development of microcytic anemia: Promising protective effects of vitamin C." Journal of research in pharmacy (online), 25, ss.117 - 123, 2021. 10.29228/jrp.2
ISNAD	Ibragic, Saida vd. "Artificial sweeteners elicit oxidative stress in rat brain and development of microcytic anemia: Promising protective effects of vitamin C". Journal of research in pharmacy (online) 25/2 (2021), 117-123. https://doi.org/10.29228/jrp.2