Yıl: 2021 Cilt: 25 Sayı: 2 Sayfa Aralığı: 179 - 195 Metin Dili: İngilizce DOI: 10.29228/jrp.9 İndeks Tarihi: 31-05-2021

Conceptual design and optimization of self microemulsifying drug delivery systems for dapsone by using Box-Behnken design

Öz:
Dapsone is a class II BCS with antibacterial and anti-inflammatory action. The goal of this study was to devise a dapsone (DP) system of solid self-microemulsifying drug delivery (S-SMEDDS). Various proportions of capryol 90 as an oil form, tween 80 as a surfactant and Labrasol as a co-surfactant were selected to prepare a pseudo ternary diagram for the self-microemulsifying drug delivery system (L-SMEDDS). The optimized formulation of L-SMEDDS (F8) containing capryol 90 (10 percent w/w), Tween 80 (67.5/5 w/w), and labrasol (22.5 percent w/w) showed the smallest particle size, less emulsification time, high optical clarity, in-vitrorelease and improved ex-vivo permeation.L-SMEDDDS was converted to S-SMEDDS by adsorbing on neusilin US2 and spray drying with aerosil 200. The effect of inlet temperature (A), feed flow rate (B) and carrier concentration (C) on particle size (Y1) and % practical yield (Y2) was studied using Box-Behnken design. Using the results of dependent variables, polynomial equations, surface response plots, and contour plots were developed. S-SMEDDS have been tested for flow properties, drug quality, reconstitution properties, DSC, XRD, SEM, drug release in vitroand anti-inflammatory activity in vivo. The present study showed the applicability of design of experiments (DOE)to optimize the process parameters needed to produce DP S-SMEDDS as an effective approach to improving its solubility.
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APA Mahore J, Shelar A, Deshkar s, MORE G (2021). Conceptual design and optimization of self microemulsifying drug delivery systems for dapsone by using Box-Behnken design. , 179 - 195. 10.29228/jrp.9
Chicago Mahore Jayashri,Shelar Aniket,Deshkar sanjeevani,MORE GHANSAHM Conceptual design and optimization of self microemulsifying drug delivery systems for dapsone by using Box-Behnken design. (2021): 179 - 195. 10.29228/jrp.9
MLA Mahore Jayashri,Shelar Aniket,Deshkar sanjeevani,MORE GHANSAHM Conceptual design and optimization of self microemulsifying drug delivery systems for dapsone by using Box-Behnken design. , 2021, ss.179 - 195. 10.29228/jrp.9
AMA Mahore J,Shelar A,Deshkar s,MORE G Conceptual design and optimization of self microemulsifying drug delivery systems for dapsone by using Box-Behnken design. . 2021; 179 - 195. 10.29228/jrp.9
Vancouver Mahore J,Shelar A,Deshkar s,MORE G Conceptual design and optimization of self microemulsifying drug delivery systems for dapsone by using Box-Behnken design. . 2021; 179 - 195. 10.29228/jrp.9
IEEE Mahore J,Shelar A,Deshkar s,MORE G "Conceptual design and optimization of self microemulsifying drug delivery systems for dapsone by using Box-Behnken design." , ss.179 - 195, 2021. 10.29228/jrp.9
ISNAD Mahore, Jayashri vd. "Conceptual design and optimization of self microemulsifying drug delivery systems for dapsone by using Box-Behnken design". (2021), 179-195. https://doi.org/10.29228/jrp.9
APA Mahore J, Shelar A, Deshkar s, MORE G (2021). Conceptual design and optimization of self microemulsifying drug delivery systems for dapsone by using Box-Behnken design. Journal of research in pharmacy (online), 25(2), 179 - 195. 10.29228/jrp.9
Chicago Mahore Jayashri,Shelar Aniket,Deshkar sanjeevani,MORE GHANSAHM Conceptual design and optimization of self microemulsifying drug delivery systems for dapsone by using Box-Behnken design. Journal of research in pharmacy (online) 25, no.2 (2021): 179 - 195. 10.29228/jrp.9
MLA Mahore Jayashri,Shelar Aniket,Deshkar sanjeevani,MORE GHANSAHM Conceptual design and optimization of self microemulsifying drug delivery systems for dapsone by using Box-Behnken design. Journal of research in pharmacy (online), vol.25, no.2, 2021, ss.179 - 195. 10.29228/jrp.9
AMA Mahore J,Shelar A,Deshkar s,MORE G Conceptual design and optimization of self microemulsifying drug delivery systems for dapsone by using Box-Behnken design. Journal of research in pharmacy (online). 2021; 25(2): 179 - 195. 10.29228/jrp.9
Vancouver Mahore J,Shelar A,Deshkar s,MORE G Conceptual design and optimization of self microemulsifying drug delivery systems for dapsone by using Box-Behnken design. Journal of research in pharmacy (online). 2021; 25(2): 179 - 195. 10.29228/jrp.9
IEEE Mahore J,Shelar A,Deshkar s,MORE G "Conceptual design and optimization of self microemulsifying drug delivery systems for dapsone by using Box-Behnken design." Journal of research in pharmacy (online), 25, ss.179 - 195, 2021. 10.29228/jrp.9
ISNAD Mahore, Jayashri vd. "Conceptual design and optimization of self microemulsifying drug delivery systems for dapsone by using Box-Behnken design". Journal of research in pharmacy (online) 25/2 (2021), 179-195. https://doi.org/10.29228/jrp.9