The Evaluation of Brain Volume in Children with Epilepsy onMagnetic Resonance Imaging by Stereological Method
Yıl: 2021 Cilt: 27 Sayı: 1 Sayfa Aralığı: 23 - 31 Metin Dili: İngilizce DOI: 10.14744/epilepsi.2020.63644 İndeks Tarihi: 05-06-2021
The Evaluation of Brain Volume in Children with Epilepsy onMagnetic Resonance Imaging by Stereological Method
Öz: Objectives: Brain volume is important in many diseases for both children and adults. Studies examining brain volume in terms of seizure types are less although several studies examining brain volume on healthy and epileptic children are available. Thus, this study aims to examine the cerebral cortex, cerebral white matter, cerebral, cerebellar, and total brain volumes in terms of epilepsy-related factors in children diagnosed with idiopathic epilepsy.Methods: Cranial magnetic resonance images of 100 children (girls, 50; boys, 50), aged 3–16 years old, who had idiopathic epilepsy with generalized and partial seizures were retrospectively evaluated. The volumetric measurements of the cerebral cortex, cerebral white matter, cerebrum, cerebellum, and total brain were performed using the Cavalieri principle, which is one of the methods for volume calculation with stereology techniques.Results: No significant difference was noted in the brain volumes between partial and generalized seizure groups. However, asymmetry on ce-rebral cortex volume in both seizure groups was determined. Similarly, no correlation was found between epilepsy duration, seizure frequency, use of antiepileptic drugs, and brain volumes.Conclusion: Studies comparing two different seizure types are relatively less among the studies examining brain volume in childhood epilepsy. Thus, the study of brain volume in children with partial and generalized seizures diagnosed with idiopathic epilepsy will contribute to the studies conducted in this area, and the results obtained are essential for understanding the impact of epilepsy and epilepsy-related factors on brain volume.
Anahtar Kelime: Epilepsili Çocuklarda Beyin Hacminin Manyetik Rezonans Görüntüleri ÜzerindeStereolojik Yöntemle Değerlendirilmesi
Öz: Amaç: Beyin hacmi birçok hastalıkta hem çocuklar hem de yetişkinler için önemlidir. Epileptik ve sağlıklı çocuklarda beyin hacminin incelendiği birçok çalışma olmasına rağmen, beyin hacminin nöbet tipleri açısından incelendiği çalışmaların daha az olduğu görülmektedir. Bu çalışmanın amacı, idiyopatik epilepsi tanılı çocuklarda serebral korteks, hemisferik beyaz cevher, serebrum, serebellum ve toplam beyin hacminin epilepsi ile ilişkili faktörler açısından incelenmesidir.Gereç ve Yöntem:Çalışmada, idiyopatik epilepsi tanılı parsiyel ve jeneralize nöbetleri olan 3-16 yaş arası 50’si kız, 50’si erkek toplam 100 çocu-ğun kraniyal manyetik rezonans görüntüleri retrospektif olarak incelenmiştir. Serebral korteks, hemisferik beyaz cevher, serebrum, serebellum ve toplam beyin hacim ölçümleri, stereoloji teknikleri ile hacim hesaplama yöntemlerinden biri olan Cavalieri prensibiyle hesaplanmıştır.Bulgular:Parsiyel ve jeneralize nöbet grupları arasında beyin hacimlerinde anlamlı bir fark olmadığı saptanmıştır (p>0.05). Ancak her iki nöbet grubunda serebral korteks asimetrisi tespit edilmiştir. Epilepsi süresi, nöbet sıklığı, antiepileptik ilaç kullanımı ve beyin hacimleri arasında an-lamlı bir ilişki olmadığı görülmüştür (p>0.05).Sonuç:Çocukluk çağı epilepsilerinde beyin hacmini inceleyen çalışmalar arasında, iki farklı nöbet tipini karşılaştıran çalışmaların daha az oldu-ğu bilinmektedir. Bu çalışmada, idiyopatik epilepsi tanısı alan parsiyel ve jeneralize nöbetleri olan çocuklarda beyin hacminin incelenmesinin bu alanda yapılan çalışmalara katkıda bulunacağı ve elde edilen sonuçların epilepsi ve epilepsi ile ilişkili faktörlerin beyin hacmi üzerine etkisini anlamak adına önemli olduğu düşünülmektedir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | ADANIR S, Cihan O, özçelik a (2021). The Evaluation of Brain Volume in Children with Epilepsy onMagnetic Resonance Imaging by Stereological Method. , 23 - 31. 10.14744/epilepsi.2020.63644 |
| Chicago | ADANIR Saliha Seda,Cihan Omer Faruk,özçelik ayşe aysima The Evaluation of Brain Volume in Children with Epilepsy onMagnetic Resonance Imaging by Stereological Method. (2021): 23 - 31. 10.14744/epilepsi.2020.63644 |
| MLA | ADANIR Saliha Seda,Cihan Omer Faruk,özçelik ayşe aysima The Evaluation of Brain Volume in Children with Epilepsy onMagnetic Resonance Imaging by Stereological Method. , 2021, ss.23 - 31. 10.14744/epilepsi.2020.63644 |
| AMA | ADANIR S,Cihan O,özçelik a The Evaluation of Brain Volume in Children with Epilepsy onMagnetic Resonance Imaging by Stereological Method. . 2021; 23 - 31. 10.14744/epilepsi.2020.63644 |
| Vancouver | ADANIR S,Cihan O,özçelik a The Evaluation of Brain Volume in Children with Epilepsy onMagnetic Resonance Imaging by Stereological Method. . 2021; 23 - 31. 10.14744/epilepsi.2020.63644 |
| IEEE | ADANIR S,Cihan O,özçelik a "The Evaluation of Brain Volume in Children with Epilepsy onMagnetic Resonance Imaging by Stereological Method." , ss.23 - 31, 2021. 10.14744/epilepsi.2020.63644 |
| ISNAD | ADANIR, Saliha Seda vd. "The Evaluation of Brain Volume in Children with Epilepsy onMagnetic Resonance Imaging by Stereological Method". (2021), 23-31. https://doi.org/10.14744/epilepsi.2020.63644 |
| APA | ADANIR S, Cihan O, özçelik a (2021). The Evaluation of Brain Volume in Children with Epilepsy onMagnetic Resonance Imaging by Stereological Method. Epilepsi, 27(1), 23 - 31. 10.14744/epilepsi.2020.63644 |
| Chicago | ADANIR Saliha Seda,Cihan Omer Faruk,özçelik ayşe aysima The Evaluation of Brain Volume in Children with Epilepsy onMagnetic Resonance Imaging by Stereological Method. Epilepsi 27, no.1 (2021): 23 - 31. 10.14744/epilepsi.2020.63644 |
| MLA | ADANIR Saliha Seda,Cihan Omer Faruk,özçelik ayşe aysima The Evaluation of Brain Volume in Children with Epilepsy onMagnetic Resonance Imaging by Stereological Method. Epilepsi, vol.27, no.1, 2021, ss.23 - 31. 10.14744/epilepsi.2020.63644 |
| AMA | ADANIR S,Cihan O,özçelik a The Evaluation of Brain Volume in Children with Epilepsy onMagnetic Resonance Imaging by Stereological Method. Epilepsi. 2021; 27(1): 23 - 31. 10.14744/epilepsi.2020.63644 |
| Vancouver | ADANIR S,Cihan O,özçelik a The Evaluation of Brain Volume in Children with Epilepsy onMagnetic Resonance Imaging by Stereological Method. Epilepsi. 2021; 27(1): 23 - 31. 10.14744/epilepsi.2020.63644 |
| IEEE | ADANIR S,Cihan O,özçelik a "The Evaluation of Brain Volume in Children with Epilepsy onMagnetic Resonance Imaging by Stereological Method." Epilepsi, 27, ss.23 - 31, 2021. 10.14744/epilepsi.2020.63644 |
| ISNAD | ADANIR, Saliha Seda vd. "The Evaluation of Brain Volume in Children with Epilepsy onMagnetic Resonance Imaging by Stereological Method". Epilepsi 27/1 (2021), 23-31. https://doi.org/10.14744/epilepsi.2020.63644 |
