Fatma HANCI
(Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, Çocuk Nörolojisi Anabilim Dalı, Çocuk Hastalıkları Anabilim Dalı, Bolu, Türkiye)
Sevim TÜRAY
(Düzce Üniversitesi, Tıp Fakültesi, Pediatri Anabilim Dalı, Düzce, Türkiye)
Hüseyin KOCABEY
(Düzce Üniversitesi, Tıp Fakültesi, Pediatri Anabilim Dalı, Düzce, Türkiye)
Nimet KABAKUŞ
(Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, Çocuk Nörolojisi Anabilim Dalı, Çocuk Hastalıkları Anabilim Dalı, Bolu, Türkiye)
Yıl: 2021Cilt: 27Sayı: 1ISSN: 1300-7157Sayfa Aralığı: 39 - 46İngilizce

88 0
Probable Risk Factors for Epilepsy Development Following Febrile Seizure: A Retrospective, Observational Study
Objectives: The purpose of this study was to investigate the risk factors for epilepsy development following febrile seizure (FS).Methods: This study included 449 patients undergoing first FS between 2014 and 2017. The sociodemographic, clinical, and electroenceph-alography (EEG) characteristics of the patients were retrieved from hospital records. Patients followed-up for at least 3 years after FS were divided into two groups (epilepsy and FS group; FS only group).Results: Of the 449 patients followed-up due to FS (238 [53.2%] boys and 211 [46.8%] girls), 42 (9.4%) were diagnosed with epilepsy during follow-up. The mean age at the time of the first FS was 21.4±14.5 months. A positive family history of FS and epilepsy was observed in 217 (48.3%) and 66 (14.7%) patients, respectively. In terms of FS characteristics, the prevalence of complex FS was significantly higher in the sub-sequent epilepsy group. The presence of a history of perinatal asphyxia and epileptiform or background abnormality findings at first EEG was also significantly higher in the subsequent epilepsy group (p<0.001).Conclusion: The findings of this study show that a history of perinatal asphyxia, complex FS, and epileptiform discharges at initial EEG exhib-ited an increased association with epilepsy development.
DergiAraştırma MakalesiErişime Açık
  • 1. Steering Committee on Quality Improvement and Management, Subcommittee on Febrile Seizures American Academy of Pediatrics. Febrile seizures: clinical practice guideline for the long-term management of the child with simple febrile seizures. Pediatrics 2008;121(6):1281–6.
  • 2. Berg AT, Shinnar S, Levy SR, Testa FM. Childhood-onset epilepsy with and without preceding febrile seizures. Neurology 1999;53(8):1742–8.
  • 3. Hamati-Haddad A, Abou-Khalil B. Epilepsy diagnosis and localization in patients with antecedent childhood febrile convulsions. Neurology 1998;50(4):917–22.
  • 4. Chungath M, Shorvon S. The mortality and morbidity of febrile seizures. Nat Clin Pract Neurol 2008;4(11):610–21.
  • 5. Vestergaard M, Pedersen CB, Sidenius P, Olsen J, Christensen J. The long-term risk of epilepsy after febrile seizures in susceptible subgroups. Am J Epidemiol 2007;165(8):911–8.
  • 6. Chiang LM, Huang GS, Sun CC, Hsiao YL, Hui CK, Hu MH. Association of developing childhood epilepsy subsequent to febrile seizure: A population-based cohort study. Brain Dev 2018;40(9):775–80.
  • 7. Kim H, Byun SH, Kim JS, Lim BC, Chae JH, Choi J, et al. Clinical and EEG risk factors for subsequent epilepsy in patients with complex febrile seizures. Epilepsy Res 2013;105(1-2):158–63.
  • 8. Gradisnik P, Zagradisnik B, Palfy M, Kokalj-Vokac N, Marcun-Varda N. Predictive value of paroxysmal EEG abnormalities for future epilepsy in focal febrile seizures. Brain Dev 2015;37(9):868– 73.
  • 9. Fisher RS, Cross JH, D’Souza C, French JA, Haut SR, Higurashi N, et al. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531–42.
  • 10. Anlar B ,Yalaz K. Denver II gelişimsel tarama testi Türk çocuklarına uyarlanması ve standardizasyonu el kitabı (Türkçe). Ankara: Meteksan Matbası; 1996.
  • 11. Gencpinar P, Yavuz H, Bozkurt Ö, Haspolat Ş, Duman Ö. The risk of subsequent epilepsy in children with febrile seizure after 5 years of age. Seizure 2017;53:62–5.
  • 12. Lee SH, Byeon JH, Kim GH, Eun BL, Eun SH. Epilepsy in children with a history of febrile seizures. Korean J Pediatr 2016;59(2):74– 9.
  • 13. Fallah R, Akhavan Karbasi S, Golestan M. Afebrile seizure subsequent to initial febrile seizure. Singapore Med J 2012;53:349– 52.
  • 14. Nelson KB, Ellenberg JH. Predictors of epilepsy in children who have experienced febrile seizures. N Engl J Med 1976;295(19):1029–33.
  • 15. Kanemura H, Mizorogi S, Aoyagi K, Sugita K, Aihara M. EEG characteristics predict subsequent epilepsy in children with febrile seizure. Brain Dev 2012;34(4):302–7.
  • 16. Reilly C, Atkinson P, Das KB, Chin RF, Aylett SE, Burch V, et al. Neurobehavioral comorbidities in children with active epilepsy: a population-based study. Pediatrics 2014;133(6):e1586–93.
  • 17. Berg AT, Langfitt JT, Testa FM, Levy SR, DiMario F, Westerveld M, et al. Global cognitive function in children with epilepsy: a community-based study. Epilepsia 2008;49(4):608–14.
  • 18. Weiss EF, Masur D, Shinnar S, Hesdorffer DC, Hinton VJ, Bonner M, et al; FEBSTAT study team. Cognitive functioning one month and one year following febrile status epilepticus. Epilepsy Behav 2016;64(Pt A):283–8.
  • 19. Natsume J, Hamano SI, Iyoda K, Kanemura H, Kubota M, Mimaki M, et al. New guidelines for management of febrile seizures in Japan. Brain Dev 2017;39(1):2–9.
  • 20. Hesdorffer DC, Shinnar S, Lewis DV, Nordli DR Jr, Pellock JM, Moshé SL, et al; Consequences of Prolonged Febrile Seizures in Childhood (FEBSTAT) Study Team. Risk factors for febrile status epilepticus: a case-control study. J Pediatr 2013;163(4):1147– 51.e1.

TÜBİTAK ULAKBİM Ulusal Akademik Ağ ve Bilgi Merkezi Cahit Arf Bilgi Merkezi © 2019 Tüm Hakları Saklıdır.