Epistaxis is the most common nasal emergency. In this case report, we aimed to present a patient who presented to the emergency department with epistaxis-related deep anemia in the light of the literature. A 73-year-oldmale patient applied to the emergency service with nasal bleeding since yesterday despite the nasal tampon.He had epistaxis for three days. The pulse of the patient was 97 beats/min, rhythmic and blood pressure was90/61 mmHg. The nasal septum was cauterized. Tampon was placed in the right nasal passage again. Bleedingstarted again after two hours. The laboratory results were hemoglobin 6.7 g/dl and hematocrit 21.5%. On thesecond day of the hospitalization, the patient was operated due to nasal bleeding. The sphenopalatine arterywas endoscopically ligated. The patient was discharged without any complications. Although epistaxis is oftenself-limited, it can be life-threatening in rare cases. Physicians should keep in mind that surgical treatment maybe necessary in the treatment of epistaxis.