Changes on Hepatitis C virus genotype distribution in Western Turkey: Evaluation of twelve-year data
Yıl: 2020 Cilt: 31 Sayı: 2 Sayfa Aralığı: 128 - 135 Metin Dili: İngilizce DOI: 10.5152/tjg.2020.18798 İndeks Tarihi: 09-06-2021
Changes on Hepatitis C virus genotype distribution in Western Turkey: Evaluation of twelve-year data
Öz: Background/Aims: Hepatitis C virus (HCV) prevalence is 1% in Turkey with genotype 1 being the predominant type traditionally. However unique geographical location of Turkey and increasing human migration in the region influences the epidemiology of the infection. The aim of this study was to determine the changes in distribution of HCV genotypes and risk factors.Materials and Methods: In this retrospective single-center study, HCV genotyping results of 558 patients were evaluated in between 2005 and 2016.Three different HCV genotyping assays were used during the 12-year study period;restriction fragment length polymorphism (RFLP), Abbott Real Time HCV Genotype II and Bosphore HCV genotyping kit.Results: The most prevalent HCV genotype was genotype 1 detected in 88.4% of the patients followed by genotype 3 (5.2%),genotype 4 (2.9%),genotype 2 (2.1%), mixed genotypes (1.1%) and genotype 5 (0.3%).Genotype 1a showed an increasing prevalence.There were 19 patients (3.4%) either of foreign nationalities or Turkish citizens living abroad. Genotype 3 was the most common type among these patients which 10.3% had intravenous drug use history.Syrian migrant population differed in terms of HCV genotypes.Genotype 5 detected in two Syrian patients, which is the first report of HCV type 5 in Western Turkey. Among the HCV genotype 4 infected patients, 31.3% were Syrians.Conclusion: Our study showed that although genotype 1b dominance continues, the distribution and prevalence of HCV genotypes are changing in our region mainly due to migration and increase in the frequency of patients with non-traditional risk factors such as intravenous drug use. Monitoring the epidemiology of HCV genotypes may provide guidance in treatment decisions.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Ishii S, Koziel MJ. Immune responses during acute and chronic infection with hepatitis C virus. Clin Immunol 2008; 128: 133-47.
- 2. Gower E, Estes C, Blach S, Razavi-Shearer K, Razavi H. Global ep idemiology and genotype distribution of the hepatitis C virus infec tion. J Hepatol 2014; 61: 45-57.
- 3. Tozun N, Ozdogan O, Cakaloglu Y, et al. Seroprevalence of hepa titis B and C virus infections and risk factors in Turkey: a field-work TURHEP study. Clin Microbiol Infect 2015; 21: 1020-6.
- 4. Simmonds P. Genetic diversity and evolution of hepatitis C virüs-15 years on. Gen Virol 2004; 85: 3173-88.
- 5. McOmish F, Yap PL, Dow BC, et al. Geographical distribution of hepatitis C virus genotypes in blood donors: an international collab orative survey. J Clin Microbiol 1994; 32: 884-92.
- 6. Ciccozzi M, Ciccaglione AR, Lo Presti A, et al. Reconstruction of the evolutionary Dynamics of the hepatitis C virus 1b epidemic in Turkey. Infect Genet Evol 2011; 11: 863-8.
- 7. Abacıoglu YH, Davidson F, Tuncer S, et al. The distribution of hep atitis C virus genotypes in Turkish patients. J Viral Hepat 1995; 2: 297-301.
- 8. Bozdayi AM, Aslan N, Bozdayi G, et al. Molecular epidemiology of hepatitis B, C and D viruses in Turkish patients. Arch Virol 2004; 149: 2115-29.
- 9. Altuglu I, Soyler I, Ozacar T, Erensoy S. Distribution of hepatitis C virus genotypes in patients with chronic hepatitis C infection in Western Turkey. Int J Infect Dis 2008; 12: 239-44.
- 10. Gökahmetoğlu S, Atalay MA, Kılınç A. Determination of the hep atitis C virus genotypes with ‘pyrosequencing’ method. Erciyes Med J 2011; 33: 99-102.
- 11. Buruk CK, Bayramoglu G, Reis A, Kaklıkkaya N, Tosun I, Aydın F. Determination of hepatitis C virus genotypes among hepatitis C pa tients in eastern black sea region, Turkey. Mikrobiyol Bul 2013; 47: 650-7.
- 12. Altuğlu I, Sertöz R, Aksoy A, Gürsel D, Tüzüner U, Günşar F. Possi ble transmission risks and genotype distribution of hepatitis C virus infection in Western Turkey. Turk J Gastroenterol 2013; 24: 349-55.
- 13. Sağlik İ, Mutlu D, Öngut G, et al. Distribution of Hepatitis C Vi rus Genotypes among Patients with Chronic Hepatitis C Infection in Akdeniz University Hospital, Antalya, Turkey: A Five-Year Evaluation. Mikrobiyol Bul 2014; 48: 429-37.
- 14. Kuşçu F, Kömür S, Seza Inal A, et al. Changing Epidemiology of Chronic Hepatitis C in Adana. Viral Hepat J 2014; 20: 15-8.
- 15. Çalışkan A, Kirisci O, Ozkaya E, et al. Distribution and Predomi nance of Genotype 3 in Hepatitis C Virus Carriers in the Province of Kahramanmaras, Turkey. Hepat Mon 2015; 15: e25142.
- 16. Üçbilek E, Abayli B, Koyuncu MB, et al. Distrubition of hepatitis C virus genotypes among intravenous drug users in Çukurova Region of Turkey. Turk J Med Sci 2016; 46: 66-71.
- 17. Cetin Duran A, Kibar F, Cetiner S, Yaman A. Determination of Hepatitis C virus genotype and HCV infection transmission routes in Cukurova University Medical Faculty Hospital. Turk Hij Den Biyol Derg 2017; 74: 201-10.
- 18. Aguilera A, Navarro D, Rodríguez-Frias F, et al. Prevalence and dis tribution of hepatitis C virus in Spain during the 2000-2015 period (The GEHEP 005 Study). J Viral Hepat 2017; 24: 725-32.
- 19. Kartashev V, Döring M, Nieto L, Coletta E, Kaiser R, Sierra S. HCV EuResist Study group. New findings in HCV genotype distribution in selected West European, Russian and Israeli regions. J Clin Virol 2016; 81: 82-9.
- 20. Yıldırım MS, Yayla B and Cirit OS. HCV genotyping data of the Gaziantep Dr. Ersin Arslan State Hospital: Is this the first detection of genotype 5 in Turkey? Presented at 2nd National Clinical Micro biology Congress (poster number: PS432), November 2013, Antalya, Turkey (in Turkish)
- 21. Petruzziello A, Marigliano S, Loquercio G, Cozzolino A, Cac ciapuoti C. Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus geno types. World J Gastroenterol 2016; 22: 7824-40.
- 22.Antaki N, Haddad M, Kebbewar K, et al. The unexpected discovery of a focus of hepatitis C virus genotype 5 in a Syrian province. Epide miol Infect 2009; 137: 79-84.
- 23. Legrand-Abravanel F, Sandres-Sauné K, Barange K, et al. Hep atitis C virus genotype 5: epidemiological characteristics and sensi tivity to combination therapy with interferon-alpha plus ribavirin. J Infect Dis 2004; 189: 1397-400.
- 24. Delwaide J, Gerard C, Reenaers C, et al. Hepatitis C virus geno type 5 in southern Belgium: epidemiological characteristics and re sponse to therapy. Dig Dis Sci 2005; 50: 2348-51.
- 25. Epidemiology of hepatitis C in Turkey. Excerpt based on presen tations of S Erensoy and H Abacıoğlu at “Burden and Prevention of Viral Hepatitis in Turkey” meeting. Viral Hepatitis 2010; 18: 8-9.
- 26. Yıldırım B, Tahan V, Ozaras R, et al. Hepatitis C Virus Risk Factors in the Turkish Community. Dig Dis Sci 2005; 50: 2352-5.
- 27. Kuzin SN, Samokhvalov EI, Zabotina EE, et al. Hepatitis virus genotype structure in patients with chronic hepatitis C. Zh Mikrobiol Epidemiol Immunobiol 2011; 3: 33-8.
- 28. Rantala M, van de Laar MJW. Surveillance and epidemiology of hepatitis B and C in Europe- a review. Euro Surveill. 2008; 13. pii: 18880.
- 29. Esteban JI, Sauleda S, Quer J. The Changing Epidemiology of Hepatitis C Virus Infection in Europe. J Hepatol 2008; 48: 148-62.
- 30. Bourlière M, Pietri O. HCV therapy: no one to let behind. Int J An timicrob Agents 2018; pii: S0924-8579(18)30380-7.
APA | cetin duran a, Çetinkaya Ö, SAYINER A, Seydaoglu G, Özkarataş E, Abacioglu H (2020). Changes on Hepatitis C virus genotype distribution in Western Turkey: Evaluation of twelve-year data. , 128 - 135. 10.5152/tjg.2020.18798 |
Chicago | cetin duran alev,Çetinkaya Özgül,SAYINER AYCA ARZU,Seydaoglu Gulsah,Özkarataş Emre,Abacioglu Hakan Changes on Hepatitis C virus genotype distribution in Western Turkey: Evaluation of twelve-year data. (2020): 128 - 135. 10.5152/tjg.2020.18798 |
MLA | cetin duran alev,Çetinkaya Özgül,SAYINER AYCA ARZU,Seydaoglu Gulsah,Özkarataş Emre,Abacioglu Hakan Changes on Hepatitis C virus genotype distribution in Western Turkey: Evaluation of twelve-year data. , 2020, ss.128 - 135. 10.5152/tjg.2020.18798 |
AMA | cetin duran a,Çetinkaya Ö,SAYINER A,Seydaoglu G,Özkarataş E,Abacioglu H Changes on Hepatitis C virus genotype distribution in Western Turkey: Evaluation of twelve-year data. . 2020; 128 - 135. 10.5152/tjg.2020.18798 |
Vancouver | cetin duran a,Çetinkaya Ö,SAYINER A,Seydaoglu G,Özkarataş E,Abacioglu H Changes on Hepatitis C virus genotype distribution in Western Turkey: Evaluation of twelve-year data. . 2020; 128 - 135. 10.5152/tjg.2020.18798 |
IEEE | cetin duran a,Çetinkaya Ö,SAYINER A,Seydaoglu G,Özkarataş E,Abacioglu H "Changes on Hepatitis C virus genotype distribution in Western Turkey: Evaluation of twelve-year data." , ss.128 - 135, 2020. 10.5152/tjg.2020.18798 |
ISNAD | cetin duran, alev vd. "Changes on Hepatitis C virus genotype distribution in Western Turkey: Evaluation of twelve-year data". (2020), 128-135. https://doi.org/10.5152/tjg.2020.18798 |
APA | cetin duran a, Çetinkaya Ö, SAYINER A, Seydaoglu G, Özkarataş E, Abacioglu H (2020). Changes on Hepatitis C virus genotype distribution in Western Turkey: Evaluation of twelve-year data. Turkish Journal of Gastroenterology, 31(2), 128 - 135. 10.5152/tjg.2020.18798 |
Chicago | cetin duran alev,Çetinkaya Özgül,SAYINER AYCA ARZU,Seydaoglu Gulsah,Özkarataş Emre,Abacioglu Hakan Changes on Hepatitis C virus genotype distribution in Western Turkey: Evaluation of twelve-year data. Turkish Journal of Gastroenterology 31, no.2 (2020): 128 - 135. 10.5152/tjg.2020.18798 |
MLA | cetin duran alev,Çetinkaya Özgül,SAYINER AYCA ARZU,Seydaoglu Gulsah,Özkarataş Emre,Abacioglu Hakan Changes on Hepatitis C virus genotype distribution in Western Turkey: Evaluation of twelve-year data. Turkish Journal of Gastroenterology, vol.31, no.2, 2020, ss.128 - 135. 10.5152/tjg.2020.18798 |
AMA | cetin duran a,Çetinkaya Ö,SAYINER A,Seydaoglu G,Özkarataş E,Abacioglu H Changes on Hepatitis C virus genotype distribution in Western Turkey: Evaluation of twelve-year data. Turkish Journal of Gastroenterology. 2020; 31(2): 128 - 135. 10.5152/tjg.2020.18798 |
Vancouver | cetin duran a,Çetinkaya Ö,SAYINER A,Seydaoglu G,Özkarataş E,Abacioglu H Changes on Hepatitis C virus genotype distribution in Western Turkey: Evaluation of twelve-year data. Turkish Journal of Gastroenterology. 2020; 31(2): 128 - 135. 10.5152/tjg.2020.18798 |
IEEE | cetin duran a,Çetinkaya Ö,SAYINER A,Seydaoglu G,Özkarataş E,Abacioglu H "Changes on Hepatitis C virus genotype distribution in Western Turkey: Evaluation of twelve-year data." Turkish Journal of Gastroenterology, 31, ss.128 - 135, 2020. 10.5152/tjg.2020.18798 |
ISNAD | cetin duran, alev vd. "Changes on Hepatitis C virus genotype distribution in Western Turkey: Evaluation of twelve-year data". Turkish Journal of Gastroenterology 31/2 (2020), 128-135. https://doi.org/10.5152/tjg.2020.18798 |