Analysis of correlation between liver fat fraction and AST and ALT levels in overweight and obese children by using new magnetic resonance imaging technique

POLAT, GÖKHAN; Kantarci, Mecit; sade, recep; PİRİMOĞLU, Berhan; Islek, Ali

doi:10.5152/tjg.2020.18594

Analysis of correlation between liver fat fraction and AST and ALT levels in overweight and obese children by using new magnetic resonance imaging technique

RÜSTEM BERHAN PİRİMOĞLU, (Atatürk Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Erzurum, Türkiye)

Recep SADE, (Atatürk Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Erzurum, Türkiye)

Gökhan POLAT, (Atatürk Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Erzurum, Türkiye)

Ali İŞLEK, (Atatürk Üniversitesi, Tıp Fakültesi, Çocuk Gastroenteroloji ve Beslenme Anabilim Dalı, Erzurum, Türkiye)

Mecit KANTARCI (Atatürk Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Erzurum, Türkiye)

Turkish Journal of Gastroenterology

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Yıl: 2020 Cilt: 31 Sayı: 2 Sayfa Aralığı: 156 - 162 Metin Dili: İngilizce DOI: 10.5152/tjg.2020.18594 İndeks Tarihi: 09-06-2021

Analysis of correlation between liver fat fraction and AST and ALT levels in overweight and obese children by using new magnetic resonance imaging technique

Öz:

Background/Aims: Proton density fat fraction (PDFF) magnetic resonance (MR) imaging can be a useful technique for volumetric measurements of liver fat. The purpose of our study was to evaluate the correlation between liver fat fraction (LFF) and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in children who are overweight and obese.Materials and Methods: Overall, 25 children, aged 9-17 years, were included. Patients with a body mass index (BMI) z-score between 85-95th percentile (12 of 25 patients) were assigned to the overweight group, and those with BMI z-score above 95th percentile (13 of 25 patients) were assigned to the obese group. The control group comprised 12 healthy children with BMI z-score below 85th percentile. Liver fat fraction measurements were performed on 3D volume measurement workstation by using PDFF magnetic resonance (MR) images. Spearman’s correlation coefficients between liver fat fraction and AST and ALT levels were evaluated individually for overweight, obese, and control groups. Receiver operator characteristics (ROC) analysis was also performed.Results: In the overweight and obese groups, the liver proton density fat fraction and AST levels had a strong correlation (r=0.716, p<0.001). In addition, the LFF and ALT levels demonstrated a strong correlation (r=0.878, p<0.001). ROC analysis ascertained an optimal liver fat fraction threshold of 114 for predicting AST level (sensitivity=75%, specificity=89%). ROC analysis ascertained an optimal LFF threshold of 114 for predicting ALT level (sensitivity=80%, specificity=90%).Conclusion: Our results indicate a strong correlation between LFF values and AST and ALT levels in children who are overweight and obese

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	PİRİMOĞLU B, sade r, POLAT G, Islek A, Kantarci M (2020). Analysis of correlation between liver fat fraction and AST and ALT levels in overweight and obese children by using new magnetic resonance imaging technique. , 156 - 162. 10.5152/tjg.2020.18594
Chicago	PİRİMOĞLU Berhan,sade recep,POLAT GÖKHAN,Islek Ali,Kantarci Mecit Analysis of correlation between liver fat fraction and AST and ALT levels in overweight and obese children by using new magnetic resonance imaging technique. (2020): 156 - 162. 10.5152/tjg.2020.18594
MLA	PİRİMOĞLU Berhan,sade recep,POLAT GÖKHAN,Islek Ali,Kantarci Mecit Analysis of correlation between liver fat fraction and AST and ALT levels in overweight and obese children by using new magnetic resonance imaging technique. , 2020, ss.156 - 162. 10.5152/tjg.2020.18594
AMA	PİRİMOĞLU B,sade r,POLAT G,Islek A,Kantarci M Analysis of correlation between liver fat fraction and AST and ALT levels in overweight and obese children by using new magnetic resonance imaging technique. . 2020; 156 - 162. 10.5152/tjg.2020.18594
Vancouver	PİRİMOĞLU B,sade r,POLAT G,Islek A,Kantarci M Analysis of correlation between liver fat fraction and AST and ALT levels in overweight and obese children by using new magnetic resonance imaging technique. . 2020; 156 - 162. 10.5152/tjg.2020.18594
IEEE	PİRİMOĞLU B,sade r,POLAT G,Islek A,Kantarci M "Analysis of correlation between liver fat fraction and AST and ALT levels in overweight and obese children by using new magnetic resonance imaging technique." , ss.156 - 162, 2020. 10.5152/tjg.2020.18594
ISNAD	PİRİMOĞLU, Berhan vd. "Analysis of correlation between liver fat fraction and AST and ALT levels in overweight and obese children by using new magnetic resonance imaging technique". (2020), 156-162. https://doi.org/10.5152/tjg.2020.18594

APA	PİRİMOĞLU B, sade r, POLAT G, Islek A, Kantarci M (2020). Analysis of correlation between liver fat fraction and AST and ALT levels in overweight and obese children by using new magnetic resonance imaging technique. Turkish Journal of Gastroenterology, 31(2), 156 - 162. 10.5152/tjg.2020.18594
Chicago	PİRİMOĞLU Berhan,sade recep,POLAT GÖKHAN,Islek Ali,Kantarci Mecit Analysis of correlation between liver fat fraction and AST and ALT levels in overweight and obese children by using new magnetic resonance imaging technique. Turkish Journal of Gastroenterology 31, no.2 (2020): 156 - 162. 10.5152/tjg.2020.18594
MLA	PİRİMOĞLU Berhan,sade recep,POLAT GÖKHAN,Islek Ali,Kantarci Mecit Analysis of correlation between liver fat fraction and AST and ALT levels in overweight and obese children by using new magnetic resonance imaging technique. Turkish Journal of Gastroenterology, vol.31, no.2, 2020, ss.156 - 162. 10.5152/tjg.2020.18594
AMA	PİRİMOĞLU B,sade r,POLAT G,Islek A,Kantarci M Analysis of correlation between liver fat fraction and AST and ALT levels in overweight and obese children by using new magnetic resonance imaging technique. Turkish Journal of Gastroenterology. 2020; 31(2): 156 - 162. 10.5152/tjg.2020.18594
Vancouver	PİRİMOĞLU B,sade r,POLAT G,Islek A,Kantarci M Analysis of correlation between liver fat fraction and AST and ALT levels in overweight and obese children by using new magnetic resonance imaging technique. Turkish Journal of Gastroenterology. 2020; 31(2): 156 - 162. 10.5152/tjg.2020.18594
IEEE	PİRİMOĞLU B,sade r,POLAT G,Islek A,Kantarci M "Analysis of correlation between liver fat fraction and AST and ALT levels in overweight and obese children by using new magnetic resonance imaging technique." Turkish Journal of Gastroenterology, 31, ss.156 - 162, 2020. 10.5152/tjg.2020.18594
ISNAD	PİRİMOĞLU, Berhan vd. "Analysis of correlation between liver fat fraction and AST and ALT levels in overweight and obese children by using new magnetic resonance imaging technique". Turkish Journal of Gastroenterology 31/2 (2020), 156-162. https://doi.org/10.5152/tjg.2020.18594