Yıl: 2021 Cilt: 8 Sayı: 2 Sayfa Aralığı: 160 - 166 Metin Dili: İngilizce DOI: 10.14744/nci.2020.89725 İndeks Tarihi: 09-05-2021

Comparison of “burden of disease” in elderly and non-elderly patients with pre-diabetes: A cross-sectional study

Öz:
OBJECTIVE: There are a lot of studies comparing elderly and adult patients with diabetes but not pre-diabetes systematically. We aimed to compare the discrepancies of clinical status and burden of disease in elderly (≥60 years old) versus non-elderly (18–59 years old) adult pre-diabetics.METHODS: A total of 126 pre-diabetic patients were included in the study and were compared as two groups; the elderly (n=32) and non-elderly (n=94). Fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c) levels, body mass index (BMI), the homeostasis model assessment of insulin resistance (HOMA-IR), health-related quality of life using the short form36 (SF-36) questionnaire, and disability using the health assessment questionnaire (HAQ) were evaluated.RESULTS: Gender, BMI, the presence of obesity, the ratio of HOMA-IR, FPG, and plasma glucose in the 2nd h oral glucose tolerance test were similar in non-elderly patients with pre-diabetes compared to the elderly ones. However, HbA1c levels were higher in elderly subjects in our study. According to the SF-36 questionnaire and HAQ score, there were no significant differences between groups. The median total HAQ scores were 0.125 (non-elderly) and 0.250 (elderly) for groups and there was no significant difference (p=0.099).CONCLUSION: In the similar gender and BMI groups, pre-diabetes in the elderly gives different outcomes according to HbA1c. Since SF-36 questionnaire and HAQ scores were not statistically different in both pre-diabetic groups, the burden of disease is thought to be basically due to the presence of the disease rather than aging.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Bilandzic A, Rosella L. The cost of diabetes in Canada over 10 years: applying attributable health care costs to a diabetes incidence prediction model. Health Promot Chronic Dis Prev Can 2017;37:49–53.
  • 2. American Diabetes Association. Standards of medical care in diabetes-2017. Diabetes Care 2017;40:S11–24.
  • 3. Menke A, Casagrande S, Geiss L, Cowie CC. Prevalence of and trends in diabetes among adults in the United States, 1988-2012. JAMA 2015;314:1021–9.
  • 4. Wang L, Gao P, Zhang M, Huang Z, Zhang D, Deng Q, et al. Prevalence and Ethnic Pattern of Diabetes and Prediabetes in China in 2013. JAMA 2017;317:2515–23.
  • 5. Satman I, Omer B, Tutuncu Y, Kalaca S, Gedik S, Dinccag N, et al; TURDEP-II Study Group. Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults. Eur J Epidemiol 2013;28:169–80.
  • 6. Stefan N, Fritsche A, Schick F, Häring HU. Phenotypes of prediabetes and stratification of cardiometabolic risk. Lancet Diabetes Endocrinol 2016;4:789–98.
  • 7. Rubin RR, Peyrot M. Quality of life and diabetes. Diabetes Metab Res Rev 1999;15:205–18.
  • 8. Mathur S, Zammitt NN, Frier BM. Optimal glycaemic control in elderly people with type 2 diabetes: what does the evidence say? Drug Saf 2015;38:17–32.
  • 9. Chentli F, Azzoug S, Mahgoun S. Diabetes mellitus in elderly. Indian J Endocrinol Metab 2015;19:744–52.
  • 10. Nguyen HV, Tran TT, Nguyen CT, Tran TH, Tran BX, Latkin CA, et al. Impact of comorbid chronic conditions to quality of life among elderly patients with diabetes mellitus in Vietnam. Int J Environ Res Public Health 2019;16:531.
  • 11. Trief PM, Wade MJ, Pine D, Weinstock RS. A comparison of health-related quality of life of elderly and younger insulin-treated adults with diabetes. Age Ageing 2003;32:613–8.
  • 12. Ozlu E, Uzuncakmak TK, Takır M, Akdeniz N, Karadag AS. Comparison of cutaneous manifestations in diabetic and nondiabetic obese patients: A prospective, controlled study. North Clin Istanb 2018;5:114–9.
  • 13. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2000;894:i-xii, 1–253.
  • 14. Haffner SM, Miettinen H, Stern MP. The homeostasis model in the San Antonio Heart Study. Diabetes Care 1997;20:1087–92.
  • 15. Ware J, Snow KK, Kosinski MA, Gandek BG. SF-36 health survey. Manual and interpretation guide. Boston, MA: New England Medical Center, The Health Institute; 1993.
  • 16. Haywood KL, Garratt AM, Fitzpatrick R. Quality of life in older people: a structured review of generic self-assessed health instruments. Qual Life Res 2005;14:1651–68.
  • 17. Yildirim A, Akinci F, Gozu H, Sargin H, Orbay E, Sargin M. Translation, cultural adaptation, cross-validation of the Turkish diabetes quality-of-life (DQOL) measure. Qual Life Res 2007;16:873–9.
  • 18. Fries JF, Spitz PW, Young DY. The dimensions of health outcomes: the health assessment questionnaire, disability and pain scales. J Rheumatol 1982;9:789–93.
  • 19. Wolfe F, Pincus T, Fries JF. Usefulness of the HAQ in the clinic. Ann Rheum Dis 2001;60:811.
  • 20. Wolfe F. Which HAQ is best? A comparison of the HAQ, MHAQ and RA-HAQ, a difficult 8 item HAQ (DHAQ), and a rescored 20 item HAQ (HAQ20): analyses in 2,491 rheumatoid arthritis patients following leflunomide initiation. J Rheumatol 2001;28:982–9.
  • 21. Bruce B, Fries JF. The Stanford Health Assessment Questionnaire: a review of its history, issues, progress, and documentation. J Rheumatol 2003;30:167–78.
  • 22. Odding E, Valkenburg HA, Stam HJ, Hofman A. Determinants of locomotor disability in people aged 55 years and over: the Rotterdam Study. Eur J Epidemiol 2001;17:1033–41.
  • 23. Küçükdeveci AA, Sahin H, Ataman S, Griffiths B, Tennant A. Issues in cross-cultural validity: example from the adaptation, reliability, and validity testing of a Turkish version of the Stanford Health Assessment Questionnaire. Arthritis Rheum 2004;51:14–9.
  • 24. Rabijewski M, Papierska L, Kuczerowski R, Piątkiewicz P. Hormonal determinants of the severity of andropausal and depressive symptoms in middle-aged and elderly men with prediabetes. Clin Interv Aging 2015;10:1381–91.
  • 25. Wu S, Yi F, Zhou C, Zhang M, Zhu Y, Tuniyazi Y, et al. HbA1c and the diagnosis of diabetes and prediabetes in a middle-aged and elderly Han population from northwest China (HbA1c). J Diabetes 2013;5:282–90.
  • 26. Yan ST, Xiao HY, Tian H, Li CL, Fang FS, Li XY, et al. The cutoffs and performance of glycated hemoglobin for diagnosing diabetes and prediabetes in a young and middle-aged population and in an elderly population. Diabetes Res Clin Pract 2015;109:238–45.
  • 27. Chen G, Shi L, Cai L, Lin W, Huang H, Liang J, et al. Comparison of Insulin Resistance and β-Cell Dysfunction Between the Young and the Elderly in Normal Glucose Tolerance and Prediabetes Population: A Prospective Study. Horm Metab Res 2017;49:135–41.
  • 28. Rabijewski M, Papierska L, Maksym R, Tomasiuk R, Kajdy A, Siekierski BP. The Relationship Between Health-Related Quality of Life and Anabolic Hormone Levels in Middle-Aged and Elderly Men With Prediabetes: A Cross-Sectional Study. Am J Mens Health 2018;12:1593– 603.
  • 29. Wu L, Lin H, Gao J, Li X, Xia M, Wang D, et al. Effect of age on the diagnostic efficiency of HbA1c for diabetes in a Chinese middle-aged and elderly population: The Shanghai Changfeng Study. PLoS One 2017;12:e0184607.
  • 30. Kramer CK, Araneta MR, Barrett-Connor E. A1C and diabetes diagnosis: The Rancho Bernardo Study. Diabetes Care 2010;33:101–3.
  • 31. Lv X, Gao B, Wu Y, Li S, Tian H, Yang L, et al. The value of HbA1c for diagnosis of diabetes mellitus and prediabetes in Tibetan population. Chinese Journal of Diabetes 2013;21:686–8.
  • 32. Cowie CC, Rust KF, Byrd-Holt DD, Gregg EW, Ford ES, Geiss LS, et al. Prevalence of diabetes and high risk for diabetes using A1C criteria in the U.S. population in 1988-2006. Diabetes Care 2010;33:562–8.
  • 33. Pani LN, Korenda L, Meigs JB, Driver C, Chamany S, Fox CS, et al. Effect of aging on A1C levels in individuals without diabetes: evidence from the Framingham Offspring Study and the National Health and Nutrition Examination Survey 2001-2004. Diabetes Care 2008;31:1991–6.
  • 34. Liu J, Wu YY, Huang XM, Yang M, Zha BB, Wang F, et al. Ageing and type 2 diabetes in an elderly Chinese population: the role of insulin resistance and beta cell dysfunction. Eur Rev Med Pharmacol Sci 2014;18:1790–7.
  • 35. Lima MG, Barros MB, César CL, Goldbaum M, Carandina L, Ciconelli RM. Health related quality of life among the elderly: a population-based study using SF-36 survey. Cad Saude Publica 2009;25:2159–67.
  • 36. Doosti-Irani A, Nedjat S, Nedjat S, Cheraghi P, Cheraghi Z. Quality of life in Iranian elderly population using the SF-36 questionnaire: systematic review and meta-analysis. East Mediterr Health J 2019;24:1088– 97.
  • 37. Tourani S, Behzadifar M, Martini M, Aryankhesal A, Taheri Mirghaed M, Salemi M, et al. Health-related quality of life among healthy elderly Iranians: a systematic review and meta-analysis of the literature. Health Qual Life Outcomes 2018;16:18.
  • 38. Miller DK, Lui LY, Perry HM 3rd, Kaiser FE, Morley JE. Reported and measured physical functioning in older inner-city diabetic African Americans. J Gerontol A Biol Sci Med Sci 1999;54:M230–6.
  • 39. Salomé GM, Ferreira LM. Impact of non-adherent Ibuprofen foam dressing in the lives of patients with venous ulcers. Rev Col Bras Cir 2017;44:116–24
APA topaloglu u, Erol K (2021). Comparison of “burden of disease” in elderly and non-elderly patients with pre-diabetes: A cross-sectional study. , 160 - 166. 10.14744/nci.2020.89725
Chicago topaloglu ulasserkan,Erol Kemal Comparison of “burden of disease” in elderly and non-elderly patients with pre-diabetes: A cross-sectional study. (2021): 160 - 166. 10.14744/nci.2020.89725
MLA topaloglu ulasserkan,Erol Kemal Comparison of “burden of disease” in elderly and non-elderly patients with pre-diabetes: A cross-sectional study. , 2021, ss.160 - 166. 10.14744/nci.2020.89725
AMA topaloglu u,Erol K Comparison of “burden of disease” in elderly and non-elderly patients with pre-diabetes: A cross-sectional study. . 2021; 160 - 166. 10.14744/nci.2020.89725
Vancouver topaloglu u,Erol K Comparison of “burden of disease” in elderly and non-elderly patients with pre-diabetes: A cross-sectional study. . 2021; 160 - 166. 10.14744/nci.2020.89725
IEEE topaloglu u,Erol K "Comparison of “burden of disease” in elderly and non-elderly patients with pre-diabetes: A cross-sectional study." , ss.160 - 166, 2021. 10.14744/nci.2020.89725
ISNAD topaloglu, ulasserkan - Erol, Kemal. "Comparison of “burden of disease” in elderly and non-elderly patients with pre-diabetes: A cross-sectional study". (2021), 160-166. https://doi.org/10.14744/nci.2020.89725
APA topaloglu u, Erol K (2021). Comparison of “burden of disease” in elderly and non-elderly patients with pre-diabetes: A cross-sectional study. İstanbul Kuzey Klinikleri, 8(2), 160 - 166. 10.14744/nci.2020.89725
Chicago topaloglu ulasserkan,Erol Kemal Comparison of “burden of disease” in elderly and non-elderly patients with pre-diabetes: A cross-sectional study. İstanbul Kuzey Klinikleri 8, no.2 (2021): 160 - 166. 10.14744/nci.2020.89725
MLA topaloglu ulasserkan,Erol Kemal Comparison of “burden of disease” in elderly and non-elderly patients with pre-diabetes: A cross-sectional study. İstanbul Kuzey Klinikleri, vol.8, no.2, 2021, ss.160 - 166. 10.14744/nci.2020.89725
AMA topaloglu u,Erol K Comparison of “burden of disease” in elderly and non-elderly patients with pre-diabetes: A cross-sectional study. İstanbul Kuzey Klinikleri. 2021; 8(2): 160 - 166. 10.14744/nci.2020.89725
Vancouver topaloglu u,Erol K Comparison of “burden of disease” in elderly and non-elderly patients with pre-diabetes: A cross-sectional study. İstanbul Kuzey Klinikleri. 2021; 8(2): 160 - 166. 10.14744/nci.2020.89725
IEEE topaloglu u,Erol K "Comparison of “burden of disease” in elderly and non-elderly patients with pre-diabetes: A cross-sectional study." İstanbul Kuzey Klinikleri, 8, ss.160 - 166, 2021. 10.14744/nci.2020.89725
ISNAD topaloglu, ulasserkan - Erol, Kemal. "Comparison of “burden of disease” in elderly and non-elderly patients with pre-diabetes: A cross-sectional study". İstanbul Kuzey Klinikleri 8/2 (2021), 160-166. https://doi.org/10.14744/nci.2020.89725