Purpose: It was aimed to determine the effi cacy of transscleral diode laser cyclophotocoagulation (TDLCP) in refractory glaucoma.Materials and Methods: We retrospectively reviewed fi les of patients underwent TDLCP procedures at Eye Clinic of Celal Bayar University Hospital between January 2010 and December 2014. Overall, 41 eyes of 41 patients (21 right, 20 left eyes) with refractory glaucoma were included in the study. Intraocular pressure (IOP) before and after treatment, visual acuity, the number of medications and complications were analyzed.Results: Twenty-one (48.7%) of the cases were female. Mean age was 49.6±22.02 years (range 6-87 years). Mean follow-up was 15.07±5.36 months (range 12-36 months). Mean IOP was 37.65±11.22 mmHg before treatment and 24.87±11.20 mmHg at last follow-up (p<0.001). In 70.7% of the cases, effi cacy was achieved with single session of TDLCP, and the mean number of treatment was 1.36. Mean IOP shows a reduction by 53.6% at 1 week and by 33.9% at last follow-up. IOP of ≤22 mmHg was recorded in 48.8% of eyes at the last follow-up visit. Mean number of anti-glaucoma drugs was 3.68±0.72 before TDLCP and 3±0.89 at last follow-up (p<0.001). Pre-treatment the use of acetazolamide rate was 41.5% and 7.3% at last follow-up was (p<0.001). Hyphema was developed in 2 cases whereas phthisis bulbi in one and hypotonia in 3 cases.Conclusion: TDLCP is an effective procedure with signifi cant and long-term IOP reduction in refractory glaucoma. Therewithal, it provides a signifi cant reduction in the use of both topical and oral anti-glaucoma drugs.