The Association of Collagen 1A1, 5A1 and 12A1 Gene Expression withGeneral Joint Laxity in Athletes is Non-Significant

Babayeva, Naila; Ozkan, Omer; Torgutalp, Serife Seyma; Korkusuz, Feza; ALP, ALPASLAN; Akdoğan Kittana, Fatma Nur

doi:10.5152/tjsm.2020.191

The Association of Collagen 1A1, 5A1 and 12A1 Gene Expression withGeneral Joint Laxity in Athletes is Non-Significant

Şerife Şeyma TORĞUTALP, (Spor Hekimliği Bölümü, Gaziler Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi, Ankara, Türkiye)

Naila BABAYEVA, (Hacettepe Üniversitesi Tıp Fakültesi, Spor Hekimliği Anabilim Dalı, Ankara, Türkiye)

Ömer ÖZKAN, (Hacettepe Üniversitesi Tıp Fakültesi, Spor Hekimliği Anabilim Dalı, Ankara, Türkiye)

Fatmanur Akdoğan KITTANA, (Hacettepe Üniversitesi Tıp Fakültesi Tıbbi Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye)

Alpaslan ALP, (Hacettepe Üniversitesi Tıp Fakültesi Tıbbi Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye)

Feza KORKUSUZ (Hacettepe Üniversitesi Tıp Fakültesi, Spor Hekimliği Anabilim Dalı, Ankara, Türkiye)

Spor Hekimliği Dergisi

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Yıl: 2020 Cilt: 55 Sayı: 4 Sayfa Aralığı: 308 - 313 Metin Dili: İngilizce DOI: 10.5152/tjsm.2020.191 İndeks Tarihi: 11-05-2021

The Association of Collagen 1A1, 5A1 and 12A1 Gene Expression withGeneral Joint Laxity in Athletes is Non-Significant

Öz:

Objective: Generalized joint laxity is a connective tissue disorder, and may cause musculoskeletal injury in athletes. The gene expression levels of type I, V, and XII collagens affect the components and properties of connective tissue. Therefore, in this study, we aimed to investigate the COL1A1, COL5A1, and COL12A1 gene expression levels, which have an effect on connective tissue properties and were previously associated with ligament injuries in athletes and assess their association with generalized joint laxity.Materials and Methods: 20 athletes were included in this study. Joint laxity was evaluated according to the Beighton Horan Joint Mobility Index (BHJMI). The participants were divided into two groups as non-hypermobile (n=11) and increased mobility and hypermobility (n=9) according to their BHJMI scores. The real-time polymerase chain reaction was used to determine the COL1A1, COL5A1, and COL12A1 gene expression levels.Results: There were no significant differences in the relative gene expressions of COL1A1, COL5A1, or COL12A1 between the groups.Conclusion: The gene expression levels of collagen types I, III, and V of participants with and without generalized joint laxity were not different. Genome-wide studies are recommended to evaluate the potential genetic variants associated with hypermobility, which causes sport-related injuries.

Anahtar Kelime:

Sporcularda Kollajen 1A1, 5A1 ve 12A1 Gen Ekspresyonlarının Genel Eklem Laksitesi İle İlişkisi Anlamlı Değildir

Öz:

Amaç: Genel eklem laksitesi bir bağ dokusu bozukluğu olup, sporcularda kas-iskeletsistemi yaralanmalarına neden olabilir. Tip I, V ve XII kollajenlerin gen ekspresyonseviyeleri bağ dokusunun bileşenlerini ve özelliklerini etkilemektedir. Bu nedenle, buçalışmada bağ dokusu özellikleri üzerine etkisi olan ve daha önce sporculardakiligament yaralanmaları ile ilişkisi gösterilmiş olan COL1A1, COL5A1 ve COL12A1 genekspresyonlarının düzeylerinin ve bu gen ekspresyonlarının genel eklem laksitesi ileilişkisinin araştırılması amaçlanmıştır. Gereç ve Yöntemler: Toplam 20 sporcu çalışmaya dahil edildi. Eklem laksitesiBeighton Horan Eklem Mobilite İndeksine (BHJMI) göre değerlendirildi. KatılımcılarBHJMI skorlarına göre hipermobilitesi olmayan (n=11) ile artmış mobilite vehipermobilitesi olan (n=9) olmak üzere iki gruba ayrıldı. COL1A1, COL5A1 ve COL12A1 gen ekspresyon seviyelerini saptamak için gerçek zamanlı polimeraz zincir reaksiyonu yöntemi kullanıldı. Bulgular: Gruplar arasında COL1A1, COL5A1 veya COL12A1'in gen ekspresyonlarında anlamlı fark bulunmadı. Sonuç: Genel eklem laksitesi olan ve olmayan katılımcıların kollajen tip I, III ve V gen ekspresyonları arasındaanlamlı fark bulunmadı. Spor yaralanmalarına sebep olan hipermobilite ile ilgili potansiyel genetik varyantlarındeğerlendirilmesi için genom boyutunda ilişkilendirme çalışmaları önerilmektedir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Torgutalp S, Babayeva N, Ozkan O, Akdoğan Kittana F, ALP A, Korkusuz F (2020). The Association of Collagen 1A1, 5A1 and 12A1 Gene Expression withGeneral Joint Laxity in Athletes is Non-Significant. , 308 - 313. 10.5152/tjsm.2020.191
Chicago	Torgutalp Serife Seyma,Babayeva Naila,Ozkan Omer,Akdoğan Kittana Fatma Nur,ALP ALPASLAN,Korkusuz Feza The Association of Collagen 1A1, 5A1 and 12A1 Gene Expression withGeneral Joint Laxity in Athletes is Non-Significant. (2020): 308 - 313. 10.5152/tjsm.2020.191
MLA	Torgutalp Serife Seyma,Babayeva Naila,Ozkan Omer,Akdoğan Kittana Fatma Nur,ALP ALPASLAN,Korkusuz Feza The Association of Collagen 1A1, 5A1 and 12A1 Gene Expression withGeneral Joint Laxity in Athletes is Non-Significant. , 2020, ss.308 - 313. 10.5152/tjsm.2020.191
AMA	Torgutalp S,Babayeva N,Ozkan O,Akdoğan Kittana F,ALP A,Korkusuz F The Association of Collagen 1A1, 5A1 and 12A1 Gene Expression withGeneral Joint Laxity in Athletes is Non-Significant. . 2020; 308 - 313. 10.5152/tjsm.2020.191
Vancouver	Torgutalp S,Babayeva N,Ozkan O,Akdoğan Kittana F,ALP A,Korkusuz F The Association of Collagen 1A1, 5A1 and 12A1 Gene Expression withGeneral Joint Laxity in Athletes is Non-Significant. . 2020; 308 - 313. 10.5152/tjsm.2020.191
IEEE	Torgutalp S,Babayeva N,Ozkan O,Akdoğan Kittana F,ALP A,Korkusuz F "The Association of Collagen 1A1, 5A1 and 12A1 Gene Expression withGeneral Joint Laxity in Athletes is Non-Significant." , ss.308 - 313, 2020. 10.5152/tjsm.2020.191
ISNAD	Torgutalp, Serife Seyma vd. "The Association of Collagen 1A1, 5A1 and 12A1 Gene Expression withGeneral Joint Laxity in Athletes is Non-Significant". (2020), 308-313. https://doi.org/10.5152/tjsm.2020.191

APA	Torgutalp S, Babayeva N, Ozkan O, Akdoğan Kittana F, ALP A, Korkusuz F (2020). The Association of Collagen 1A1, 5A1 and 12A1 Gene Expression withGeneral Joint Laxity in Athletes is Non-Significant. Spor Hekimliği Dergisi, 55(4), 308 - 313. 10.5152/tjsm.2020.191
Chicago	Torgutalp Serife Seyma,Babayeva Naila,Ozkan Omer,Akdoğan Kittana Fatma Nur,ALP ALPASLAN,Korkusuz Feza The Association of Collagen 1A1, 5A1 and 12A1 Gene Expression withGeneral Joint Laxity in Athletes is Non-Significant. Spor Hekimliği Dergisi 55, no.4 (2020): 308 - 313. 10.5152/tjsm.2020.191
MLA	Torgutalp Serife Seyma,Babayeva Naila,Ozkan Omer,Akdoğan Kittana Fatma Nur,ALP ALPASLAN,Korkusuz Feza The Association of Collagen 1A1, 5A1 and 12A1 Gene Expression withGeneral Joint Laxity in Athletes is Non-Significant. Spor Hekimliği Dergisi, vol.55, no.4, 2020, ss.308 - 313. 10.5152/tjsm.2020.191
AMA	Torgutalp S,Babayeva N,Ozkan O,Akdoğan Kittana F,ALP A,Korkusuz F The Association of Collagen 1A1, 5A1 and 12A1 Gene Expression withGeneral Joint Laxity in Athletes is Non-Significant. Spor Hekimliği Dergisi. 2020; 55(4): 308 - 313. 10.5152/tjsm.2020.191
Vancouver	Torgutalp S,Babayeva N,Ozkan O,Akdoğan Kittana F,ALP A,Korkusuz F The Association of Collagen 1A1, 5A1 and 12A1 Gene Expression withGeneral Joint Laxity in Athletes is Non-Significant. Spor Hekimliği Dergisi. 2020; 55(4): 308 - 313. 10.5152/tjsm.2020.191
IEEE	Torgutalp S,Babayeva N,Ozkan O,Akdoğan Kittana F,ALP A,Korkusuz F "The Association of Collagen 1A1, 5A1 and 12A1 Gene Expression withGeneral Joint Laxity in Athletes is Non-Significant." Spor Hekimliği Dergisi, 55, ss.308 - 313, 2020. 10.5152/tjsm.2020.191
ISNAD	Torgutalp, Serife Seyma vd. "The Association of Collagen 1A1, 5A1 and 12A1 Gene Expression withGeneral Joint Laxity in Athletes is Non-Significant". Spor Hekimliği Dergisi 55/4 (2020), 308-313. https://doi.org/10.5152/tjsm.2020.191