Yıl: 2020 Cilt: 10 Sayı: 3 Sayfa Aralığı: 274 - 280 Metin Dili: İngilizce DOI: 10.5222/buchd.2020.53325 İndeks Tarihi: 13-05-2021

Investigation of Short and Long-TermComplications of Respiratory System AfterEsophageal Atresia and/or TracheoesophagealFistular Surgery

Öz:
Objective: Esophageal atresia (EA) and/or tracheoesophageal fistula (TEF) is one of the common developmental anomalies of the foregut. Despite advances in surgical techniques and postoperative care, respiratory system complications affect the quality of life of patients. We planned to evaluate our patients in terms of the general features, the risk factors for respiratory morbidity and short- and long-term respiratory complications after corrective surgical treatment. Method: Thirty-six patients with the diagnosis of EA and/or TEF and followed after surgical treatment between 2002 and 2019 were retrospectively enrolled in the study.Results: The most common symptom was chronic cough (77.7%) and wheezing (41.6%). Recurrent pulmonary infections were present in the great majority of the patients. The frequency of pulmonary infections was higher in patients who had undergone dilatation due to stricture (N=14) and in patients with recurrent TEF (N=6) and malacia (N=10). Bronchiectasis was present in eight patients and hospital admission due to infections was highly frequent. Aeroallergen sensitivity was detected in four and food allergy in five patients. Scoliosis was present in 33.3% of the patients all of whom had recurrent pulmonary infections. Pulmonary function tests were performed in 10 patients. Five patients had impaired pulmonary function. Medical treatment for reflux was given to the majority of patients (N=30), while fundoplication was performed in 10 patients. Most of the patients had a significant decrease in the frequency of pulmonary infections after the procedure. Conclusion: The etiology of pulmonary complications is multifactorial and many factors affect each other. Evaluation and management of the patients for each complication will improve the quality of life and comfort of the patients
Anahtar Kelime:

Özofagus Atrezisi ve/veya Trakeoözofageal Fistül Cerrahisi Sonrası Solunum Sistemi Erken ve Geç Dönem Komplikasyonlarının İncelenmesi

Öz:
Amaç: Özofagus atrezisi (ÖA) ve/veya trakeoözofageal fistül (TÖF) önbağırsağın en sık gelişim anomalile rinden biridir. Cerrahi teknikler ve operasyon sonrası bakımdaki ilerlemelere rağmen, solunum sistemikomplikasyonları hastaların yaşam kalitesini etkilemektedir. Bu nedenle çalışmamızda, hastaların genelözelliklerini, respiratuvar morbidite risk faktörlerini ve düzeltme operasyonu sonrası solunum sistemi erkenve geç dönem komplikasyonlarını değerlendirmeyi amaçladık. Yöntem: Çalışmaya 2002-2019 yılları arasında ÖA ve/veya TÖF tanısı ile düzeltme operasyonu sonrasıtakip edilen 36 hasta dahil edildi. Bulgular: En sık semptom kronik öksürük (%77,7) ve hışıltı (%41,6) idi. Hastaların büyük çoğunluğundayineleyen akciğer enfeksiyonu vardı. Akciğer enfeksiyonu sıklığı striktür nedeniyle dilatasyon uygulanan(N=14), rekürren TÖF (N=6) saptanan ve malazi (N=10) bulunan hastalarda daha fazlaydı. Bronşektazisekiz hastada vardı ve bu hastalarda akciğer enfeksiyonu nedeniyle hastaneye başvuru sıktı. Dört hastadaaeroallerjen duyarlılığı ve beş hastada besin alerjisi saptanmıştı. Skolyoz hastaların %33,3’ünde vardı ve buhastaların hepsinde yineleyen akciğer enfeksiyonu bulunmaktaydı. Solunum fonksiyon testi 10 hastayauygulanmıştı. Beş hastada solunum fonksiyon testinde düşüklük vardı. Hastaların büyük çoğunluğuna(N=30) reflü nedeniyle medikal tedavi başlanmıştı. On hastaya fundoplikasyon işlemi uygulanmıştı. İşlemsonrası birçok hastada akciğer enfeksiyonu sıklığında belirgin azalma gözlenmişti. Sonuç: Hastalarda pulmoner komplikasyonların etiyolojisi multifaktöriyeldir ve birçok faktör birbirini etki lemektedir. Hastaların komplikasyonlar açısından değerlendirilmesi ve yönetimi, yaşam kalitesi ve konfo runu arttıracaktır.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Sfeir R, Michaud L, Salleron J, Gottrand F. Epidemiology of esophageal atresia. Diseases of the esophagus: official journal of the International Society for Diseases of the Esophagus. 2013;26(4):354-5. https://doi.org/10.1111/dote.12051
  • 2. Pini Prato A, Carlucci M, Bagolan P, Gamba PG, Bernardi M, Leva E, et al. A cross-sectional nationwide survey on esophageal atresia and tracheoesophageal fistula. Journal of pediatric surgery. 2015;50(9):1441-56. https://doi.org/10.1016/j.jpedsurg.2015.01.004
  • 3. Malmstrom K, Lohi J, Lindahl H, Pelkonen A, Kajosaari M, Sarna S, et al. Longitudinal follow-up of bronchial inflammation, respiratory symptoms, and pulmonary function in adolescents after repair of esophageal atresia with tracheoesophageal fistula. The Journal of pediatrics. 2008;153(3):396- 401. https://doi.org/10.1016/j.jpeds.2008.03.034
  • 4. Castilloux J, Noble AJ, Faure C. Risk factors for short- and long-term morbidity in children with esophageal atresia. The Journal of pediatrics. 2010;156(5):755-60. https://doi.org/10.1016/j.jpeds.2009.11.038
  • 5. Kovesi T. Long-term respiratory complications of congenital esophageal atresia with or without tracheoesophageal fistula: an update. Diseases of the esophagus: official journal of the International Society for Diseases of the Esophagus. 2013;26(4):413-6. https://doi.org/10.1111/dote.12061
  • 6. Fragoso AC, Tovar JA. The multifactorial origin of respiratory morbidity in patients surviving neonatal repair of esophageal atresia. Frontiers in pediatrics. 2014;2:39. https://doi.org/10.3389/fped.2014.00039
  • 7. Sadreameli SC, McGrath-Morrow SA. Respiratory Care of Infants and Children with Congenital Tracheo-Oesophageal Fistula and Oesophageal Atresia. Paediatric respiratory reviews. 2016;17:16-23. https://doi.org/10.1016/j.prrv.2015.02.005
  • 8. Patria MF, Ghislanzoni S, Macchini F, Lelii M, Mori A, Leva E, et al. Respiratory morbidity in children with repaired congenital esophageal atresia with or without tracheoesophageal fistula. International Journal of Environmental Research and Public Health. 2017;14(10):1136. https://doi.org/10.3390/ijerph14101136
  • 9. Deurloo JA, Smit BJ, Ekkelkamp S, Aronson DC. Oesophageal atresia in premature infants: an analysis of morbidity and mortality over a period of 20 years. Acta paediatrica (Oslo, Norway: 1992). 2004;93(3):394-9. https://doi.org/10.1111/j.1651-2227.2004.tb02968.x
  • 10. Legrand C, Michaud L, Salleron J, Neut D, Sfeir R, Thumerelle C, et al. Long-term outcome of children with oesophageal atresia type III. Archives of disease in childhood. 2012;97(9):808-11. https://doi.org/10.1136/archdischild-2012-301730
  • 11. Pedersen RN, Markow S, Kruse-Andersen S, Qvist N, Gerke O, Husby S, et al. Long-term pulmonary function in esophageal atresia-A case-control study. Pediatric pulmonology. 2017;52(1):98-106. https://doi.org/10.1002/ppul.23477
  • 12. Sistonen S, Malmberg P, Malmstrom K, Haahtela T, Sarna S, Rintala RJ, et al. Repaired oesophageal atresia: respiratory morbidity and pulmonary function in adults. The European respiratory journal. 2010;36(5):1106-12. https://doi.org/10.1183/09031936.00153209
  • 13. Parelkar SV, Sanghvi BV, Vageriya NL, Samala DS, Paradkar BA, Oak SN. Unilateral lung agenesis associated with esophageal atresia & tracheoesophageal fistula: Report of two cases & review of literature. J Pediatr Surg Case Rep. 2014;1:203-6. https://doi.org/10.1016/j.epsc.2013.06.003
  • 14. Parolini F, Leva E, Morandi A, Macchini F, Gentilino V, Di Cesare A, et al. Anastomotic strictures and endoscopic dilatations following esophageal atresia repair. Pediatric surgery international. 2013;29(6):601-5. https://doi.org/10.1007/s00383-013-3298-4
  • 15. Celayir S, İlçe Z, Tekand GT, et al. The experience with esophagus atresia (1978-2000). Cerrahpaşa J Med. 2002;33:86-92.
  • 16. Bakal U, Ersoz F, Eker I, Sarac M, Aydin M, Kazez A. Long-term prognosis of patients with esophageal atresia and/or tracheoesophageal fistula. Indian J Pediatr. 2016;83(5):401-4. https://doi.org/10.1007/s12098-015-1930-0
  • 17. Taskınlar H, Kıllı Y, Çelik Y, Avlan D, Naycı A. Experiences in patients with esophageal atresia and tracheoesophageal fistula. Journal of the Turkish Association of Pediatric Surgeons and The Society for Pediatric Urology in Turkey. 2012;26(2):32-6. https://doi.org/10.5222/JTAPS.2012.032
  • 18. Smithers CJ, Hamilton TE, Manfredi MA, Rhein L, Ngo P, Gallagher D, et al. Categorization and repair of recurrent and acquired tracheoesophageal fistulae occurring after esophageal atresia repair. Journal of pediatric surgery. 2017;52(3):424-30. https://doi.org/10.1016/j.jpedsurg.2016.08.012
  • 19. Cartabuke RH, Lopez R, Thota PN. Long-term esophageal and respiratory outcomes in children with esophageal atresia and tracheoesophageal fistula. Gastroenterology report. 2016;4(4):310-4. https://doi.org/10.1093/gastro/gov055
  • 20. Hseu A, Recko T, Jennings R, Nuss R. Upper airway anomalies in congenital tracheoesophageal fistula and esophageal atresia patients. The Annals of Otology, Rhinology, and Laryngology. 2015;124(10):808-13. https://doi.org/10.1177/0003489415586844
  • 21. Mirra V, Maglione M, Di Micco LL, Montella S, Santamaria F. Longitudinal follow-up of chronic pulmonary manifestations in esophageal atresia: A clinical algorithm and review of the literature. Pediatrics and Neonatology. 2017;58(1):8-15. https://doi.org/10.1016/j.pedneo.2016.03.005
APA Kartal Öztürk G, Eşki A, Demir E, GULEN F (2020). Investigation of Short and Long-TermComplications of Respiratory System AfterEsophageal Atresia and/or TracheoesophagealFistular Surgery. , 274 - 280. 10.5222/buchd.2020.53325
Chicago Kartal Öztürk Gökçen,Eşki Aykut,Demir Esen,GULEN Figen Investigation of Short and Long-TermComplications of Respiratory System AfterEsophageal Atresia and/or TracheoesophagealFistular Surgery. (2020): 274 - 280. 10.5222/buchd.2020.53325
MLA Kartal Öztürk Gökçen,Eşki Aykut,Demir Esen,GULEN Figen Investigation of Short and Long-TermComplications of Respiratory System AfterEsophageal Atresia and/or TracheoesophagealFistular Surgery. , 2020, ss.274 - 280. 10.5222/buchd.2020.53325
AMA Kartal Öztürk G,Eşki A,Demir E,GULEN F Investigation of Short and Long-TermComplications of Respiratory System AfterEsophageal Atresia and/or TracheoesophagealFistular Surgery. . 2020; 274 - 280. 10.5222/buchd.2020.53325
Vancouver Kartal Öztürk G,Eşki A,Demir E,GULEN F Investigation of Short and Long-TermComplications of Respiratory System AfterEsophageal Atresia and/or TracheoesophagealFistular Surgery. . 2020; 274 - 280. 10.5222/buchd.2020.53325
IEEE Kartal Öztürk G,Eşki A,Demir E,GULEN F "Investigation of Short and Long-TermComplications of Respiratory System AfterEsophageal Atresia and/or TracheoesophagealFistular Surgery." , ss.274 - 280, 2020. 10.5222/buchd.2020.53325
ISNAD Kartal Öztürk, Gökçen vd. "Investigation of Short and Long-TermComplications of Respiratory System AfterEsophageal Atresia and/or TracheoesophagealFistular Surgery". (2020), 274-280. https://doi.org/10.5222/buchd.2020.53325
APA Kartal Öztürk G, Eşki A, Demir E, GULEN F (2020). Investigation of Short and Long-TermComplications of Respiratory System AfterEsophageal Atresia and/or TracheoesophagealFistular Surgery. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi, 10(3), 274 - 280. 10.5222/buchd.2020.53325
Chicago Kartal Öztürk Gökçen,Eşki Aykut,Demir Esen,GULEN Figen Investigation of Short and Long-TermComplications of Respiratory System AfterEsophageal Atresia and/or TracheoesophagealFistular Surgery. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi 10, no.3 (2020): 274 - 280. 10.5222/buchd.2020.53325
MLA Kartal Öztürk Gökçen,Eşki Aykut,Demir Esen,GULEN Figen Investigation of Short and Long-TermComplications of Respiratory System AfterEsophageal Atresia and/or TracheoesophagealFistular Surgery. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi, vol.10, no.3, 2020, ss.274 - 280. 10.5222/buchd.2020.53325
AMA Kartal Öztürk G,Eşki A,Demir E,GULEN F Investigation of Short and Long-TermComplications of Respiratory System AfterEsophageal Atresia and/or TracheoesophagealFistular Surgery. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi. 2020; 10(3): 274 - 280. 10.5222/buchd.2020.53325
Vancouver Kartal Öztürk G,Eşki A,Demir E,GULEN F Investigation of Short and Long-TermComplications of Respiratory System AfterEsophageal Atresia and/or TracheoesophagealFistular Surgery. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi. 2020; 10(3): 274 - 280. 10.5222/buchd.2020.53325
IEEE Kartal Öztürk G,Eşki A,Demir E,GULEN F "Investigation of Short and Long-TermComplications of Respiratory System AfterEsophageal Atresia and/or TracheoesophagealFistular Surgery." İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi, 10, ss.274 - 280, 2020. 10.5222/buchd.2020.53325
ISNAD Kartal Öztürk, Gökçen vd. "Investigation of Short and Long-TermComplications of Respiratory System AfterEsophageal Atresia and/or TracheoesophagealFistular Surgery". İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi 10/3 (2020), 274-280. https://doi.org/10.5222/buchd.2020.53325