Effect of single or multiple injection of platelet-rich plasma in comparison with hyaluronic acid on knee osteoarthritis

Erdal DİLEKCİ, (Bolu İzzet Baysal Fiziksel Tıp ve Rehabilitasyon Eğitim ve Araştırma Hastanesi, Fiziksel Tıp ve Rehabilitasyon Bölümü, Bolu, Türkiye)
KAĞAN ÖZKUK, (Uşak Üniversitesi,Tıp Fakültesi, Tıbbi Ekoloji ve Hidroklimatoloji Anabilim Dalı, Uşak, Türkiye)
Sinan KARDEŞ (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Tıbbi Ekoloji ve Hidroklimatoloji Anabilim Dalı, İstanbul, Türkiye)
Experimental Biomedical Research
2 0
Yıl: 2020 Cilt: 3 Sayı: 4 Sayfa Aralığı: 262 - 276 Metin Dili: İngilizce DOI: 10.30714/j-ebr.2020463622 İndeks Tarihi: 14-05-2021

Effect of single or multiple injection of platelet-rich plasma in comparison with hyaluronic acid on knee osteoarthritis

Öz:
Aim: To compare the effect of administration of 2 different doses of platelet rich plasma (PRP) and a single dose of hyaluronic acid (HA) preparation on pain and daily life activities of knee osteoarthritis (KOA) patients.Method: In this nonrandomized comparative study, three groups of patients who received either a single dose of intraarticular (IA) PRP (PRP1 group), three doses of IA PRP (PRP3 group), or single dose IA HA (HA group) were included. Assessments were before treatment, and in the 3rd week and 6th week after treatment (after the final injection). The pain-visual analog scale (VAS), Euro-Qol (EQ)-5D-3L, EQVAS, and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were used.Results: In the 3rd week, there were statistically significant differences between the PRP1-HA groups in all parameters except EQ5; between PRP3-HA groups in all parameters except EQ5 and WOMAC stiffness; and between PRP3-PRP1 groups in all parameters except EQVAS, WOMAC pain and WOMAC stiffness. In the 6th week, there were statistically significant differences between the PRP1-HA groups in all parameters except WOMAC stiffness; between PRP3-HA groups in all parameters; and between PRP3-PRP1 groups in all parameters except WOMAC pain.Conclusion: Intraarticular PRP injections (single or three doses) were found to be more beneficial in the short term in terms of pain and functional improvement than HA injection and administration of three consecutive doses of PRP may be more effective compared to single-dose PRP administration in KOA patients.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • [1] Hunter DJ, Bierma-Zeinstra S. Osteoarthritis. Lancet. 2019;393(10182):1745-59.
  • [2] French SD, Bennell KL, Nicolson PJA, et al. What do people with knee or hip osteoarthritis need to know? an international consensus list of essential statements for osteoarthritis. Arthritis Care Res. 2015;67(6):809-16.
  • [3] Kolasinski SL, Neogi T, Hochberg MC, et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Care Res. 2020;72(2):149-62.
  • [4] Bannuru RR, Osani MC, Vaysbrot EE, et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthr Cartil. 2019;27(11):1578-589.
  • [5] Bruyère O, Cooper C, Pelletier JP, et al. A consensus statement on the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) algorithm for the management of knee osteoarthritis-From evidence-based medicine to the real-life setting. Semin Arthritis Rheum. 2016;45(4):3-11.
  • [6] Fernandes L, Hagen KB, Bijlsma JWJ, et al. EULAR recommendations for the nonpharmacological core management of hip and knee osteoarthritis. Ann Rheum Dis. 2013;72(7):1125-135.
  • [7] Jüni P, Reichenbach S, Trelle S, et al. Efficacy and safety of intraarticular hylan or hyaluronic acids for osteoarthritis of the knee: A randomized controlled trial. Arthritis Rheum. 2007;56(11):3610-619.
  • [8] Paoloni J, De Vos RJ, Hamilton B, et al. Platelet-rich plasma treatment for ligament and tendon injuries. Clin J Sport Med. 2011;21(1):37-45.
  • [9] Nguyen RT, Borg-Stein J, McInnis K. Applications of Platelet-Rich Plasma in Musculoskeletal and Sports Medicine: An Evidence-Based Approach. PM R. 2011;3(3):226-50.
  • [10] Dold AP, Zywiel MG, Taylor DW, et al. Platelet-rich plasma in the management of articular cartilage pathology: A systematic review. Clin J Sport Med. 2014;24(1):31-43.
  • [11] Görmeli G, Görmeli CA, Ataoglu B, et al. Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebocontrolled trial. Knee Surgery, Sport Traumatol Arthrosc. 2017;25(3):958-65.
  • [12] Zhang HF, Wang CG, Li H, et al. Intraarticular platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: A meta-analysis. Drug Des Devel Ther. 2018;12:445-53.
  • [13] Katz J, Melzack R. Measurement of pain. Surg Clin North Am. 1999;79(2):231-52.
  • [14] EuroQol Group. EuroQol--a new facility for the measurement of health-related quality of life. Health Policy. 1990;16(3):199-208.
  • [15] Tüzün EH, Eker L, Aytar A, et al. Acceptability, reliability, validity and responsiveness of the Turkish version of WOMAC osteoarthritis index. Osteoarthr Cartil. 2005;13(1):28-33.
  • [16] Cugat R, Cuscó X, Seijas R, et al. Biologic enhancement of cartilage repair: The role of platelet-rich plasma and other commercially available growth factors. Arthrosc - J Arthrosc Relat Surg. 2015;31(4):777-83.
  • [17] Van Buul GM, Koevoet WLM, Kops N, et al. Platelet-rich plasma releasate inhibits inflammatory processes in osteoarthritic chondrocytes. Am J Sports Med. 2011;39(11):2362-370.
  • [18] O’Connell B, Wragg NM, Wilson SL. The use of PRP injections in the management of knee osteoarthritis. Cell Tissue Res. 2019;376(2):143-52.
  • [19] Alves R, Grimalt R. A Review of Platelet- Rich Plasma: History, Biology, Mechanism of Action, and Classification. Ski Appendage Disord. 2018;4(1):18-24.
  • [20] Manferdini C, Maumus M, Gabusi E, et al. Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin E2. Arthritis Rheum. 2013;65(5):1271-281.
  • [21] De Vries-Van Melle ML, Narcisi R, Kops N, et al. Chondrogenesis of mesenchymal stem cells in an osteochondral environment is mediated by the subchondral bone. Tissue Eng - Part A. 2014;20(1-2):23-33.
  • [22] Huang PH, Wang CJ, Chou WY, et al. Shortterm clinical results of intra-articular PRP injections for early osteoarthritis of the knee. Int J Surg. 2017;42:117-22.
  • [23] Meheux CJ, McCulloch PC, Lintner DM, et al. Efficacy of Intra-articular Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Systematic Review. Arthrosc - J Arthrosc Relat Surg. 2016;32(3):495-505.
  • [24] Laver L, Marom N, Dnyanesh L, et al. PRP for Degenerative Cartilage Disease: A Systematic Review of Clinical Studies. Cartilage. 2017;8(4):341-64.
  • [25] Gobbi A, Karnatzikos G, Mahajan V, et al. Platelet-Rich Plasma Treatment in Symptomatic Patients With Knee Osteoarthritis: Preliminary Results in a Group of Active Patients. Sports Health. 2012;4(2):162-72.
  • [26] Campbell KA, Saltzman BM, Mascarenhas R, et al. Does Intra-articular Platelet-Rich Plasma Injection Provide Clinically Superior Outcomes Compared with Other Therapies in the Treatment of Knee Osteoarthritis? A Systematic Review of Overlapping Metaanalyses. Arthrosc - J Arthrosc Relat Surg. 2015;31(11):2213-221.
  • [27] Chen P, Huang L, Ma Y, et al. Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses. J Orthop Surg Res. 2019;14(1):385.
  • [28] Lai LP, Stitik TP, Foye PM, et al. Use of Platelet-Rich Plasma in Intra-Articular Knee Injections for Osteoarthritis: A Systematic Review. PM R. 2015;7(6):637-48.
  • [29] Laudy ABM, Bakker EWP, Rekers M, et al. Efficacy of platelet-rich plasma injections in osteoarthritis of the knee: A systematic review and meta-analysis. Br J Sports Med. 2015;49(10):657-72.
  • [30] Kavadar G, Demircioglu DT, Celik MY, et al. Effectiveness of platelet-rich plasma in the treatment of moderate knee osteoarthritis: A randomized prospective study. J Phys Ther Sci. 2015;27(12):3863- 867.
  • [31] Jubert NJ, Rodríguez L, Reverté-Vinaixa MM, et al. Platelet-rich plasma injections for advanced knee osteoarthritis: A prospective, randomized, double-blinded clinical trial. Orthop J Sport Med. 2017;5(2).
  • [32] Vilchez-Cavazos F, Millán-Alanís JM, Blázquez-Saldaña J, et al. Comparison of the Clinical Effectiveness of Single Versus Multiple Injections of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-analysis. Orthop J Sport Med. 2019;7(12).
  • [33] Patel S, Dhillon MS, Aggarwal S, et al. Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: A prospective, double-blind, randomized trial. Am J Sports Med. 2013;41(2):356-64.
  • [34] Ornetti P, Nourissat G, Berenbaum F, et al. Does platelet-rich plasma have a role in the treatment of osteoarthritis? Jt Bone Spine. 2016;83(1):31-36.
  • [35] Gorgu M, Karanfil E, Karanfil E, et al. Importance of homogenization in plateletrich plasma researches. Exp Biomed Res. 2018;1(2):32-36.
  • [36] Montañez-Heredia E, Irízar S, Huertas PJ, et al. Intra-articular injections of platelet-rich plasma versus hyaluronic acid in the treatment of osteoarthritic knee pain: A randomized clinical trial in the context of the Spanish national health care system. Int J Mol Sci. 2016;17(7):1064.
  • [37] Raeissadat SA, Rayegani SM, Hassanabadi H, et al. Knee osteoarthritis injection choices: Platelet-rich plasma (PRP) versus hyaluronic acid (A one-year randomized clinical trial). Clin Med Insights Arthritis Musculoskelet Disord. 2015;8:1-8.
  • [38] Raeissadat SA, Rayegani SM, Ahangar AG, et al. Efficacy of Intra-articular Injection of a Newly Developed Plasma Rich in Growth Factor (PRGF) Versus Hyaluronic Acid on Pain and Function of Patients with Knee Osteoarthritis: A Single-Blinded Randomized Clinical Trial. Clin Med Insights Arthritis Musculoskelet Disord. 2017;10:1179544117733452.
  • [39] Duymus TM, Mutlu S, Dernek B, et al. Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options. Knee Surgery, Sport Traumatol Arthrosc. 2017;25(2):485-92.
  • [40] Su K, Bai Y, Wang J, et al. Comparison of hyaluronic acid and PRP intra-articular injection with combined intra-articular and intraosseous PRP injections to treat patients with knee osteoarthritis. Clin Rheumatol. 2018;37(5):1341-350.
  • [41] Han Y, Huang H, Pan J, et al. Meta-analysis Comparing Platelet-Rich Plasma vs Hyaluronic Acid Injection in Patients With Knee Osteoarthritis - PubMed. Pain Med. 2019;20(7):1418-429.
  • [42] Chang KV, Hung CY, Aliwarga F, et al. Comparative effectiveness of platelet-rich plasma injections for treating knee joint cartilage degenerative pathology: A systematic review and meta-analysis. Arch Phys Med Rehabil. 2014;95(3):562-75.
  • [43] Dai WL, Zhou AG, Zhang H, et al. Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials. Arthrosc - J Arthrosc Relat Surg. 2017;33(3):659-70.
  • [44] Xu Z, Luo J, Huang X, et al. Efficacy of Platelet-Rich Plasma in Pain and Self-Report Function in Knee Osteoarthritis: A Best- Evidence Synthesis. Am J Phys Med Rehabil. 2017;96(11):793-800.
  • [45] Dhillon MS, Patel S, John R. PRP in OA knee – update, current confusions and future options. SICOT-J. 2017;3:27.
  • [46] Kanchanatawan W, Arirachakaran A, Chaijenkij K, et al. Short-term outcomes of platelet-rich plasma injection for treatment of osteoarthritis of the knee. Knee Surgery, Sport Traumatol Arthrosc. 2016;24(5):1665- 77.
  • [47] Kon E, Filardo G, Di Martino A, et al. Platelet-rich plasma (PRP) to treat sports injuries: Evidence to support its use. Knee Surgery, Sport Traumatol Arthrosc. 2011;19(4):516-27.
  • [48] Shen L, Yuan T, Chen S, et al. The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and metaanalysis of randomized controlled trials. J Orthop Surg Res. 2017;12(1):16.
  • [49] Filardo G, Kon E, Roffi A, et al. Platelet-rich plasma: why intra-articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration. Knee Surgery, Sport Traumatol Arthrosc. 2015;23(9):2459-474.
APA dilekçi e, Özkuk K, Kardeş S (2020). Effect of single or multiple injection of platelet-rich plasma in comparison with hyaluronic acid on knee osteoarthritis. , 262 - 276. 10.30714/j-ebr.2020463622
Chicago dilekçi erdal,Özkuk Kağan,Kardeş Sinan Effect of single or multiple injection of platelet-rich plasma in comparison with hyaluronic acid on knee osteoarthritis. (2020): 262 - 276. 10.30714/j-ebr.2020463622
MLA dilekçi erdal,Özkuk Kağan,Kardeş Sinan Effect of single or multiple injection of platelet-rich plasma in comparison with hyaluronic acid on knee osteoarthritis. , 2020, ss.262 - 276. 10.30714/j-ebr.2020463622
AMA dilekçi e,Özkuk K,Kardeş S Effect of single or multiple injection of platelet-rich plasma in comparison with hyaluronic acid on knee osteoarthritis. . 2020; 262 - 276. 10.30714/j-ebr.2020463622
Vancouver dilekçi e,Özkuk K,Kardeş S Effect of single or multiple injection of platelet-rich plasma in comparison with hyaluronic acid on knee osteoarthritis. . 2020; 262 - 276. 10.30714/j-ebr.2020463622
IEEE dilekçi e,Özkuk K,Kardeş S "Effect of single or multiple injection of platelet-rich plasma in comparison with hyaluronic acid on knee osteoarthritis." , ss.262 - 276, 2020. 10.30714/j-ebr.2020463622
ISNAD dilekçi, erdal vd. "Effect of single or multiple injection of platelet-rich plasma in comparison with hyaluronic acid on knee osteoarthritis". (2020), 262-276. https://doi.org/10.30714/j-ebr.2020463622
APA dilekçi e, Özkuk K, Kardeş S (2020). Effect of single or multiple injection of platelet-rich plasma in comparison with hyaluronic acid on knee osteoarthritis. Experimental Biomedical Research, 3(4), 262 - 276. 10.30714/j-ebr.2020463622
Chicago dilekçi erdal,Özkuk Kağan,Kardeş Sinan Effect of single or multiple injection of platelet-rich plasma in comparison with hyaluronic acid on knee osteoarthritis. Experimental Biomedical Research 3, no.4 (2020): 262 - 276. 10.30714/j-ebr.2020463622
MLA dilekçi erdal,Özkuk Kağan,Kardeş Sinan Effect of single or multiple injection of platelet-rich plasma in comparison with hyaluronic acid on knee osteoarthritis. Experimental Biomedical Research, vol.3, no.4, 2020, ss.262 - 276. 10.30714/j-ebr.2020463622
AMA dilekçi e,Özkuk K,Kardeş S Effect of single or multiple injection of platelet-rich plasma in comparison with hyaluronic acid on knee osteoarthritis. Experimental Biomedical Research. 2020; 3(4): 262 - 276. 10.30714/j-ebr.2020463622
Vancouver dilekçi e,Özkuk K,Kardeş S Effect of single or multiple injection of platelet-rich plasma in comparison with hyaluronic acid on knee osteoarthritis. Experimental Biomedical Research. 2020; 3(4): 262 - 276. 10.30714/j-ebr.2020463622
IEEE dilekçi e,Özkuk K,Kardeş S "Effect of single or multiple injection of platelet-rich plasma in comparison with hyaluronic acid on knee osteoarthritis." Experimental Biomedical Research, 3, ss.262 - 276, 2020. 10.30714/j-ebr.2020463622
ISNAD dilekçi, erdal vd. "Effect of single or multiple injection of platelet-rich plasma in comparison with hyaluronic acid on knee osteoarthritis". Experimental Biomedical Research 3/4 (2020), 262-276. https://doi.org/10.30714/j-ebr.2020463622
Sayfa Oluşturulma Tarihi
17-04-2024 19:27

İLETİŞİM

TÜBİTAK ULAKBİM TR Dizin

Yüzüncüyıl, İşçi Blokları Mahallesi

Muhsin Yazıcıoğlu Caddesi No:51/C

06530 Çankaya / ANKARA +90 (312) 298 92 00

trdizin@tubitak.gov.tr

TÜBİTAK ULAKBİM Ulusal Akademik Ağ ve Bilgi Merkezi Cahit Arf Bilgi Merkezi © Tüm Hakları Saklıdır. Gizlilik Politikası Kullanım Şartları