Interferon gamma gene polymorphisms and chronichepatitis B infections in Iranian population

moudi, bita; Mahmoudzadeh- Sagheb, Hamidreza; Heidari, Zahra

doi:10.5152/tjg.2020.181024

Interferon gamma gene polymorphisms and chronichepatitis B infections in Iranian population

Zahra HEİDARİ, (Zahedan University of Medical Sciences, Department of Histology, Zahedan, Iran)

Bita MOUDİ, (Zahedan University of Medical Sciences, Department of Histology, Zahedan, Iran)

Hamidreza MAHMOUDZADEH SAGHEB (Zahedan University of Medical Sciences, Department of Histology, Zahedan, Iran)

Turkish Journal of Gastroenterology

2 0

Yıl: 2020 Cilt: 31 Sayı: 7 Sayfa Aralığı: 515 - 521 Metin Dili: İngilizce DOI: 10.5152/tjg.2020.181024 İndeks Tarihi: 14-05-2021

Interferon gamma gene polymorphisms and chronichepatitis B infections in Iranian population

Öz:

Background/Aims: Chronic hepatitis B is an important health problem in all countries. Interferon gamma (IFN-γ) is a proinflammatory T-helper 1 cytokine, which can exert antiproliferative and antitumor activities. Some single nucleotide polymorphisms (SNPs) in IFN-γ and IFN-γ R1 genes may influence the susceptibility to hepatitis B virus (HBV). Here, we evaluated the impact of IFN-γ (+874 T/A) and its receptor (-611A/G, +189G/C, and +95C/T) polymorphisms and the risk of HBV in Iranian patients.Materials and Methods: SNPs of IFN-γ and its receptor genotypes were determined in 221 infected patients with HBV and 200 people without HBV using amplification-refractory mutation system polymerase chain reaction (PCR) and PCR restriction fragment length polymorphism method.Results: In this study, we showed an obvious relationship between IFN-γ SNPs and susceptibility to chronic HBV. Our findings suggest that IFN-γ-874A allele increases the risk of disease, and carriers of the T allele have reduced susceptibility to infection. In addition, there was no relationship between the -611A/G, +189G/C, and +95C/T regions of IFN-γ R1 and HBV.Conclusion: Our observations demonstrate +874 T/A SNP as a predicting factor in patients who have the risk of HBV.

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APA	Heidari Z, moudi b, Mahmoudzadeh- Sagheb H (2020). Interferon gamma gene polymorphisms and chronichepatitis B infections in Iranian population. , 515 - 521. 10.5152/tjg.2020.181024
Chicago	Heidari Zahra,moudi bita,Mahmoudzadeh- Sagheb Hamidreza Interferon gamma gene polymorphisms and chronichepatitis B infections in Iranian population. (2020): 515 - 521. 10.5152/tjg.2020.181024
MLA	Heidari Zahra,moudi bita,Mahmoudzadeh- Sagheb Hamidreza Interferon gamma gene polymorphisms and chronichepatitis B infections in Iranian population. , 2020, ss.515 - 521. 10.5152/tjg.2020.181024
AMA	Heidari Z,moudi b,Mahmoudzadeh- Sagheb H Interferon gamma gene polymorphisms and chronichepatitis B infections in Iranian population. . 2020; 515 - 521. 10.5152/tjg.2020.181024
Vancouver	Heidari Z,moudi b,Mahmoudzadeh- Sagheb H Interferon gamma gene polymorphisms and chronichepatitis B infections in Iranian population. . 2020; 515 - 521. 10.5152/tjg.2020.181024
IEEE	Heidari Z,moudi b,Mahmoudzadeh- Sagheb H "Interferon gamma gene polymorphisms and chronichepatitis B infections in Iranian population." , ss.515 - 521, 2020. 10.5152/tjg.2020.181024
ISNAD	Heidari, Zahra vd. "Interferon gamma gene polymorphisms and chronichepatitis B infections in Iranian population". (2020), 515-521. https://doi.org/10.5152/tjg.2020.181024

APA	Heidari Z, moudi b, Mahmoudzadeh- Sagheb H (2020). Interferon gamma gene polymorphisms and chronichepatitis B infections in Iranian population. Turkish Journal of Gastroenterology, 31(7), 515 - 521. 10.5152/tjg.2020.181024
Chicago	Heidari Zahra,moudi bita,Mahmoudzadeh- Sagheb Hamidreza Interferon gamma gene polymorphisms and chronichepatitis B infections in Iranian population. Turkish Journal of Gastroenterology 31, no.7 (2020): 515 - 521. 10.5152/tjg.2020.181024
MLA	Heidari Zahra,moudi bita,Mahmoudzadeh- Sagheb Hamidreza Interferon gamma gene polymorphisms and chronichepatitis B infections in Iranian population. Turkish Journal of Gastroenterology, vol.31, no.7, 2020, ss.515 - 521. 10.5152/tjg.2020.181024
AMA	Heidari Z,moudi b,Mahmoudzadeh- Sagheb H Interferon gamma gene polymorphisms and chronichepatitis B infections in Iranian population. Turkish Journal of Gastroenterology. 2020; 31(7): 515 - 521. 10.5152/tjg.2020.181024
Vancouver	Heidari Z,moudi b,Mahmoudzadeh- Sagheb H Interferon gamma gene polymorphisms and chronichepatitis B infections in Iranian population. Turkish Journal of Gastroenterology. 2020; 31(7): 515 - 521. 10.5152/tjg.2020.181024
IEEE	Heidari Z,moudi b,Mahmoudzadeh- Sagheb H "Interferon gamma gene polymorphisms and chronichepatitis B infections in Iranian population." Turkish Journal of Gastroenterology, 31, ss.515 - 521, 2020. 10.5152/tjg.2020.181024
ISNAD	Heidari, Zahra vd. "Interferon gamma gene polymorphisms and chronichepatitis B infections in Iranian population". Turkish Journal of Gastroenterology 31/7 (2020), 515-521. https://doi.org/10.5152/tjg.2020.181024