Aim: This study aimed to determine and compare the knowledge level of senior year students studying the paramedic program at DokuzEylül (DEU), Ege (EU) and İzmir Katip Çelebi (İKÇU) universities on frequently used drugs and interventional procedures.Materials and Methods: This descriptive study was conducted with 167 students in first and emergency aid programs of three universitieswith DEU, EU and İKÇU in between March 30, 2019 and December 30, 2019. Descriptive findings were presented as percentage, mean,standard deviation, and median.Results: Of the participants, 52.1% were females and the remaining 47.9% were males. The most common issues for which the paramedicstudents felt incompetent were drug doses (58.6%) and interventional procedure complications (60.4%). The mean total score of the knowledgelevel of the paramedic students on drugs and administration methods was 54.724. The total mean total score of the knowledge level ofinterventional procedures in paramedic students was 65.653. There was no difference in the knowledge level on drugs and administrationmethods in terms of the different universities (p=0.470). However, a significant difference was found in the knowledge level on interventionalprocedures between the students studying at different universities (p=0.002). Advanced analysis revealed that the difference was due to İKÇUstudents (p<0.806) (p<0.004 for DEU and EU).Conclusion: It was determined that paramedic students had low knowledge level on drug usage and interventional procedures. Therefore, thetraining of paramedics who will work in pre-hospital emergency health service needs to be standardized while considering the deficienciesand including updates.