Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population
Yıl: 2020 Cilt: 16 Sayı: 3 Sayfa Aralığı: 197 - 202 Metin Dili: İngilizce DOI: 10.5222/BMJ.2020.18291 İndeks Tarihi: 15-05-2021
Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population
Öz: Objective: Etiopathogenesis of schizophrenia (SCZ) involves several risk genes that induce inflammation, environmental stress factors andchanges in the innate immune system. Patients with SCZ have the highest rate of cigarette smoking and severe nicotine dependence.Myeloperoxidase (MPO), a member of subfamily of peroxidases, is most abundantly expressed in immune cells. The aim of this study was toinvestigate the relationship between the MPO rs2333227 variant and SCZ/smoking etiopathogenesis.Method: The study included 54 patients with SCZ, 94 smokers and 92 healthy controls. MPO rs2333227 variant was genotyped by polymerasechain reaction- restriction fragment length polymorphism (PCR-RFLP) method. Odds ratio (OR) and 95% confidence interval (95%CI) werecalculated using the χ2 test.Results: G/G and G/A genotypes of MPO rs2333227 were detected in our study samples. The frequencies of the G/G and G/A genotypes were53.7%, 46.3%; 56.3%; 43.7%; 68.9%, 31.1% in SCZ patients, smokers, and the control group, respectively. The allele frequencies were G: 76.9%(SCZ patients), 77.4% (smokers) 83.7% (controls); A: 23.1% (SCZ patients), 22.6% (smokers), and 16.3% (controls). There was no significantdifference between the SCZ patients, smokers and controls regarding MPO rs2333227 variant either in terms of allele frequency or genotypefrequency. Then we genotyped the groups as women and men. MPO rs2333227 variant genotype distribution did not differ between men andwomen (p>0.05).Conclusion: This study does not support the role of MPO rs2333227 variant in increasing genetic risk for SCZ/smoking in Turkish population.
Anahtar Kelime: Türk Toplumunda Myeloperoksidaz Geni Fonksiyonel Varyantının Şizofreni ve Sigara ile İlişkisi
Öz: Amaç: Şizofreni (SCZ) etyopatogenezi, enflamasyon, çevresel stres faktörleri ve doğal bağışıklık sistemindeki değişiklikleri indükleyen çeşitli risk genlerini içerir. SCZ’li hastalar yüksek sigara içme oranına ve şiddetli nikotin bağımlılığına sahiptir. Peroksidaz alt familyasının bir üyesi olan miyeloperoksidaz (MPO), en çok bağışıklık hücrelerinde eksprese edilir. Bu çalışmanın amacı MPO rs2333227 varyantı ile SCZ/sigara içimi etyopatogenezi arasındaki ilişkiyi araştırmaktır. Yöntem: Çalışmaya 54 SCZ hastası, 94 sigara içen ve 92 sağlıklı kontrol dahil edildi. MPO rs2333227 varyantı polimeraz zincir reaksiyonusınırlayıcı enzim parça uzunluk polimorfizmi (PZR-RFLP) yöntemi ile genotiplendi. OR ve %95Cl güven aralığı X2 testi kullanılarak hesaplandı. Bulgular: Çalışmada hemşirelerin %84.25’i “ERAS protokolünü bilmediklerini, %88,97’si çalıştıkları klinikte ERAS protokolü uygulamalarına yer verilmediğini, %99,21’i ise “ERAS protokolüne yönelik herhangi bir yayını takip etmediğini, %99,21’i ERAS protokolünü içeren herhangi bir eğitim almadığını belirtti. Sonuç: Çalışma örneklerimizde MPO rs22333227 G/G ve G/A genotipleri saptandı. G/G ve G/A genotiplerinin sıklığı SCZ hastalarında, sigara içenlerde ve kontrol grubunda sırasıyla, %53,7, %46,3; %56,3, %43,7; %68,9, %31,1 idi. Alel sıklıkları G: %76,9 (SCZ hastaları), %77,4 (sigara içenler), %83,7 (kontroller); A %23,1 (SCZ hastaları), %22,6 (sigara içenler), %16,3 (kontroller) idi. SCZ hastaları, sigara içenler ve kontroller arasında MPO rs2333227 varyantı alele frekansı ve genotip sıklığı açısından anlamlı bir fark yoktu. Sonra grupları kadın ve erkek olarak genotipledik. MPO rs22333227 varyant genotip dağılımı kadınlar ve erkekler arasında farklı değildi (p>0.05).
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | pehlivan s, ÇETİNAY p, UYSAL M, Nursal A, Kurnaz S, Sever Ü, Aydin A, Aydin N, PEHLİVAN M (2020). Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population. , 197 - 202. 10.5222/BMJ.2020.18291 |
| Chicago | pehlivan sacide,ÇETİNAY pinar,UYSAL MEHMET ATILLA,Nursal Ayse Feyda,Kurnaz Selin,Sever Ülgen,Aydin Aybike,Aydin Nazan,PEHLİVAN MUSTAFA Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population. (2020): 197 - 202. 10.5222/BMJ.2020.18291 |
| MLA | pehlivan sacide,ÇETİNAY pinar,UYSAL MEHMET ATILLA,Nursal Ayse Feyda,Kurnaz Selin,Sever Ülgen,Aydin Aybike,Aydin Nazan,PEHLİVAN MUSTAFA Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population. , 2020, ss.197 - 202. 10.5222/BMJ.2020.18291 |
| AMA | pehlivan s,ÇETİNAY p,UYSAL M,Nursal A,Kurnaz S,Sever Ü,Aydin A,Aydin N,PEHLİVAN M Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population. . 2020; 197 - 202. 10.5222/BMJ.2020.18291 |
| Vancouver | pehlivan s,ÇETİNAY p,UYSAL M,Nursal A,Kurnaz S,Sever Ü,Aydin A,Aydin N,PEHLİVAN M Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population. . 2020; 197 - 202. 10.5222/BMJ.2020.18291 |
| IEEE | pehlivan s,ÇETİNAY p,UYSAL M,Nursal A,Kurnaz S,Sever Ü,Aydin A,Aydin N,PEHLİVAN M "Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population." , ss.197 - 202, 2020. 10.5222/BMJ.2020.18291 |
| ISNAD | pehlivan, sacide vd. "Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population". (2020), 197-202. https://doi.org/10.5222/BMJ.2020.18291 |
| APA | pehlivan s, ÇETİNAY p, UYSAL M, Nursal A, Kurnaz S, Sever Ü, Aydin A, Aydin N, PEHLİVAN M (2020). Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population. Bakırköy Tıp Dergisi, 16(3), 197 - 202. 10.5222/BMJ.2020.18291 |
| Chicago | pehlivan sacide,ÇETİNAY pinar,UYSAL MEHMET ATILLA,Nursal Ayse Feyda,Kurnaz Selin,Sever Ülgen,Aydin Aybike,Aydin Nazan,PEHLİVAN MUSTAFA Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population. Bakırköy Tıp Dergisi 16, no.3 (2020): 197 - 202. 10.5222/BMJ.2020.18291 |
| MLA | pehlivan sacide,ÇETİNAY pinar,UYSAL MEHMET ATILLA,Nursal Ayse Feyda,Kurnaz Selin,Sever Ülgen,Aydin Aybike,Aydin Nazan,PEHLİVAN MUSTAFA Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population. Bakırköy Tıp Dergisi, vol.16, no.3, 2020, ss.197 - 202. 10.5222/BMJ.2020.18291 |
| AMA | pehlivan s,ÇETİNAY p,UYSAL M,Nursal A,Kurnaz S,Sever Ü,Aydin A,Aydin N,PEHLİVAN M Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population. Bakırköy Tıp Dergisi. 2020; 16(3): 197 - 202. 10.5222/BMJ.2020.18291 |
| Vancouver | pehlivan s,ÇETİNAY p,UYSAL M,Nursal A,Kurnaz S,Sever Ü,Aydin A,Aydin N,PEHLİVAN M Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population. Bakırköy Tıp Dergisi. 2020; 16(3): 197 - 202. 10.5222/BMJ.2020.18291 |
| IEEE | pehlivan s,ÇETİNAY p,UYSAL M,Nursal A,Kurnaz S,Sever Ü,Aydin A,Aydin N,PEHLİVAN M "Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population." Bakırköy Tıp Dergisi, 16, ss.197 - 202, 2020. 10.5222/BMJ.2020.18291 |
| ISNAD | pehlivan, sacide vd. "Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population". Bakırköy Tıp Dergisi 16/3 (2020), 197-202. https://doi.org/10.5222/BMJ.2020.18291 |
