Differences Between Right and Left Colon Cancers inTerms of Clinicopathological Features and Long-termOncological Outcomes

ZENGER, SERKAN; BALIK, Emre; Bugra, Dursun; ÖZÇELİK, Uğur Can; BILGIC, CAGRI; SEVİNDİ BÜLENT GÜRBÜZ, Tarık; SOBUTAY, ERMAN

doi:10.4274/tjcd.galenos.2020.2020-4-6

Differences Between Right and Left Colon Cancers inTerms of Clinicopathological Features and Long-termOncological Outcomes

Serkan ZENGER, (VKF Amerikan Hastanesi, Genel Cerrahi Kliniği, İstanbul, Türkiye)

Tarık SEVİNDİ BÜLENT GÜRBÜZ, (VKF Amerikan Hastanesi, Genel Cerrahi Kliniği, İstanbul, Türkiye)

Uğur Can ÖZÇELİK, (VKF Amerikan Hastanesi, Genel Cerrahi Kliniği, İstanbul, Türkiye)

Çağrı BILGIC, (VKF American Hospital, Clinic of General Surgery, İstanbul, Turkey)

Erman SOBUTAY, (VKF Amerikan Hastanesi, Genel Cerrahi Kliniği, İstanbul, Türkiye)

Emre BALIK, (Koç Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, İstanbul, Türkiye)

Dursun BUĞRA (VKF Amerikan Hastanesi, Genel Cerrahi Kliniği, İstanbul, Türkiye)

Türk Kolon ve Rektum Hastalıkları Dergisi

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Yıl: 2020 Cilt: 30 Sayı: 4 Sayfa Aralığı: 253 - 260 Metin Dili: İngilizce DOI: 10.4274/tjcd.galenos.2020.2020-4-6 İndeks Tarihi: 16-05-2021

Differences Between Right and Left Colon Cancers inTerms of Clinicopathological Features and Long-termOncological Outcomes

Öz:

Aim: Although there are clinical differences in colon cancer (CC) according to the location of the tumor, the differences between right and left CC in terms of survival are not clear. Our aim was to analyze the clinicopathological differences between right and left CC and to investigate the effect of primary tumor location on recurrence and survival.Method: The data of 330 patients who underwent curative surgery for right (n=155) or left (n=175) colon cancer between 2011 and 2018 were retrospectively analyzed. Demographic characteristics, surgical data, pathological data, recurrence and survival rates of the patients were examined and the two groups were compared in terms of these parameters.Results: Male to female ratio was significantly higher and operative time was significantly longer in the left CC than in the right CC. The mean number of harvested lymph nodes was significantly higher in the right CC than the left CC (32±3 and 27±9, respectively, p=0.001). Compared to patients with left CC, those with right CC had higher tumor diameter and tumor volume, had more poorly differentiation and tended to have more mucinous and medullary type cancer. As a result of a median follow-up of 54 months, it was determined that the 5-year overall survival in stage I-III patients was worse in the right CC than in the left CC. Especially in stage III patients, both overall and disease-free survival rates were found to be statistically significantly lower in the right CC compared to the left CC (In stage III disease, overall survival was 66.9% in right CC and 81.8% in left CC, p=0.03; disease-free survival was 54.2% in right CC and 70.6% in left CC, p=0.04).Conclusion: There may be clinicopathological and prognostic differences in CC depending on the location of the tumor. As a result of the long followup period in our case series, the prognosis in the right CC was worse, especially in stage III patients.sağkalım oranının sağ KK’sinde sol KK’sine göre istatiktiksel olarak anlamlı derecede düşük olduğu tespit edildi (Evre 3 genel sağkalım: sağ %66,9 ve sol %81,8, p=0,03; evre 3 hastalıksız sağkalım: sağ %54,2 ve sol %70,6, p=0,04).Sonuç: Kolon kanserinde tümörün yerleşim yerine göre klinikopatolojik ve prognostik farklılıklar olabilir. Kendi serimizdeki uzun takip süresi sonucunda, sağ KK’sinde prognoz özellikle evre 3 hastalarda daha kötü seyretmektedir

Anahtar Kelime:

Öz:

Amaç: Kolon kanserinde (KK) tümörün yerleşim yerine göre klinik farklar görülmesine rağmen sağkalım açısından sağ ve sol KK arasındakideğişiklikler tam olarak netlik kazanmamıştır. Amacımız; sağ ve sol KK’si arasındaki klinikopatolojik farklılıkları analiz etmek ve primer tümöryerleşiminin nükse ve sağkalıma etkisini araştırmaktır. Yöntem: 2011-2018 tarihleri arasında, sağ (n=155) veya sol (n=175) kolon kanseri tanısıyla küratif cerrahi uygulanan 330 hastanın verileri retrospektifolarak incelendi. Hastaların demografik özellikleri, ameliyat verileri, patolojik verileri, nüks ve sağkalım oranları incelendi ve iki grup arasındakarşılaştırmalar yapıldı. Bulgular: Sol KK’sinde erkek/kadın oranı ve ameliyat süresi sağ KK’sine göre anlamlı derecede yüksekti. Çıkarılan ortalama lenf nodu sayısı sağKK’inde sol KK’sine göre anlamlı derecede fazlaydı (32±3 ve 27±9 sırasıyla, p=0,001). Ayrıca sağ KK’sinde tümör çapı ve tümör hacmi daha fazla, azdiferansiyasyon oranı, müsinöz ve medüller kanser oranı sol KK’sine göre istatistiksel olarak anlamlı derecede daha yüksekti. Ortanca 54 ay takipsonucunda, evre 1-3 hastalarda 5 yıllık genel sağkalımın sağ KK’sinde daha kötü seyrettiği özellikle evre 3 hastalarda hem genel hem de hastalıksız

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ZENGER S, SEVİNDİ BÜLENT GÜRBÜZ T, ÖZÇELİK U, BILGIC C, SOBUTAY E, BALIK E, Bugra D (2020). Differences Between Right and Left Colon Cancers inTerms of Clinicopathological Features and Long-termOncological Outcomes. , 253 - 260. 10.4274/tjcd.galenos.2020.2020-4-6
Chicago	ZENGER SERKAN,SEVİNDİ BÜLENT GÜRBÜZ Tarık,ÖZÇELİK Uğur Can,BILGIC CAGRI,SOBUTAY ERMAN,BALIK Emre,Bugra Dursun Differences Between Right and Left Colon Cancers inTerms of Clinicopathological Features and Long-termOncological Outcomes. (2020): 253 - 260. 10.4274/tjcd.galenos.2020.2020-4-6
MLA	ZENGER SERKAN,SEVİNDİ BÜLENT GÜRBÜZ Tarık,ÖZÇELİK Uğur Can,BILGIC CAGRI,SOBUTAY ERMAN,BALIK Emre,Bugra Dursun Differences Between Right and Left Colon Cancers inTerms of Clinicopathological Features and Long-termOncological Outcomes. , 2020, ss.253 - 260. 10.4274/tjcd.galenos.2020.2020-4-6
AMA	ZENGER S,SEVİNDİ BÜLENT GÜRBÜZ T,ÖZÇELİK U,BILGIC C,SOBUTAY E,BALIK E,Bugra D Differences Between Right and Left Colon Cancers inTerms of Clinicopathological Features and Long-termOncological Outcomes. . 2020; 253 - 260. 10.4274/tjcd.galenos.2020.2020-4-6
Vancouver	ZENGER S,SEVİNDİ BÜLENT GÜRBÜZ T,ÖZÇELİK U,BILGIC C,SOBUTAY E,BALIK E,Bugra D Differences Between Right and Left Colon Cancers inTerms of Clinicopathological Features and Long-termOncological Outcomes. . 2020; 253 - 260. 10.4274/tjcd.galenos.2020.2020-4-6
IEEE	ZENGER S,SEVİNDİ BÜLENT GÜRBÜZ T,ÖZÇELİK U,BILGIC C,SOBUTAY E,BALIK E,Bugra D "Differences Between Right and Left Colon Cancers inTerms of Clinicopathological Features and Long-termOncological Outcomes." , ss.253 - 260, 2020. 10.4274/tjcd.galenos.2020.2020-4-6
ISNAD	ZENGER, SERKAN vd. "Differences Between Right and Left Colon Cancers inTerms of Clinicopathological Features and Long-termOncological Outcomes". (2020), 253-260. https://doi.org/10.4274/tjcd.galenos.2020.2020-4-6

APA	ZENGER S, SEVİNDİ BÜLENT GÜRBÜZ T, ÖZÇELİK U, BILGIC C, SOBUTAY E, BALIK E, Bugra D (2020). Differences Between Right and Left Colon Cancers inTerms of Clinicopathological Features and Long-termOncological Outcomes. Türk Kolon ve Rektum Hastalıkları Dergisi, 30(4), 253 - 260. 10.4274/tjcd.galenos.2020.2020-4-6
Chicago	ZENGER SERKAN,SEVİNDİ BÜLENT GÜRBÜZ Tarık,ÖZÇELİK Uğur Can,BILGIC CAGRI,SOBUTAY ERMAN,BALIK Emre,Bugra Dursun Differences Between Right and Left Colon Cancers inTerms of Clinicopathological Features and Long-termOncological Outcomes. Türk Kolon ve Rektum Hastalıkları Dergisi 30, no.4 (2020): 253 - 260. 10.4274/tjcd.galenos.2020.2020-4-6
MLA	ZENGER SERKAN,SEVİNDİ BÜLENT GÜRBÜZ Tarık,ÖZÇELİK Uğur Can,BILGIC CAGRI,SOBUTAY ERMAN,BALIK Emre,Bugra Dursun Differences Between Right and Left Colon Cancers inTerms of Clinicopathological Features and Long-termOncological Outcomes. Türk Kolon ve Rektum Hastalıkları Dergisi, vol.30, no.4, 2020, ss.253 - 260. 10.4274/tjcd.galenos.2020.2020-4-6
AMA	ZENGER S,SEVİNDİ BÜLENT GÜRBÜZ T,ÖZÇELİK U,BILGIC C,SOBUTAY E,BALIK E,Bugra D Differences Between Right and Left Colon Cancers inTerms of Clinicopathological Features and Long-termOncological Outcomes. Türk Kolon ve Rektum Hastalıkları Dergisi. 2020; 30(4): 253 - 260. 10.4274/tjcd.galenos.2020.2020-4-6
Vancouver	ZENGER S,SEVİNDİ BÜLENT GÜRBÜZ T,ÖZÇELİK U,BILGIC C,SOBUTAY E,BALIK E,Bugra D Differences Between Right and Left Colon Cancers inTerms of Clinicopathological Features and Long-termOncological Outcomes. Türk Kolon ve Rektum Hastalıkları Dergisi. 2020; 30(4): 253 - 260. 10.4274/tjcd.galenos.2020.2020-4-6
IEEE	ZENGER S,SEVİNDİ BÜLENT GÜRBÜZ T,ÖZÇELİK U,BILGIC C,SOBUTAY E,BALIK E,Bugra D "Differences Between Right and Left Colon Cancers inTerms of Clinicopathological Features and Long-termOncological Outcomes." Türk Kolon ve Rektum Hastalıkları Dergisi, 30, ss.253 - 260, 2020. 10.4274/tjcd.galenos.2020.2020-4-6
ISNAD	ZENGER, SERKAN vd. "Differences Between Right and Left Colon Cancers inTerms of Clinicopathological Features and Long-termOncological Outcomes". Türk Kolon ve Rektum Hastalıkları Dergisi 30/4 (2020), 253-260. https://doi.org/10.4274/tjcd.galenos.2020.2020-4-6