Correlation Between Perfusion Abnormalities Extent in Ventilation/Perfusion SPECT/CT with Hemodynamic Parameters in Patients with Chronic Thromboembolic Pulmonary Hypertension

Öz:

Objectives: Chronic thromboembolic pulmonary hypertension (CTEPH) is a type of pulmonary hypertension with persistent pulmonary vascular obstruction and exercise intolerance, which may benefit from pulmonary endarterectomy (PEA). Ventilation/perfusion (V/Q) scan is the preferred screening test of CTEPH, which can be used to assess the anatomical extent of the disease. This study aimed to analyze the correlation between the extent of mismatched Q defects in V/Q single photon emission computed tomography/computed tomography (SPECT/CT) with preoperative clinical and hemodynamic parameters in patients with CTEPH.Methods: A total of 102 patients with CTEPH prior to PEA having V/Q SPECT/CT scans were retrospectively reviewed. Age, gender, New York Heart Association classification, intraoperative right-sided heart catheterization (mPAP and PVR), and 6-minute walk test (6MWT) findings were obtained from clinical records of patients.Results: Linear regression analysis showed a significant but weak correlation between the preoperative mPAP and PVR with the extent of mismatched Q defects in V/Q SPECT/CT (rs=0.09474 with p=0.0016 and rs=0.045 with p=0.045, respectively). No significant correlation was found between 6MWT and extent of mismatched Q defects in V/Q SPECT/CT (p>0.05).Conclusion: A quantitative assessment of Q defects on V/Q SPECT/CT might provide information about hemodynamic parameters in patients with CTEPH.

Anahtar Kelime:

Kronik Tromboembolik Pulmoner Hipertansiyonlu Hastalarda Ventilasyon/Perfüzyon SPECT/BT’de Saptanan Perfüzyon Defekti Yaygınlığı ile Hemodinamik Parametreler Arasındaki İlişki

Öz:

Amaç: Kronik tromboembolik pulmoner hipertansiyon (KTEPH), kalıcı pulmoner vasküler obstrüksiyon ve egzersiz intoleransı ile karakterize bir pulmoner hipertansiyon grubudur ve pulmoner endarterektomiden (PEA) fayda görebilir. Ventilasyon/perfüzyon (V/Q) sintigrafisi, hastalığın anatomik yaygınlığını değerlendirmek için kullanılabilen KTEPH’nin tercih edilen tarama testidir. Bu çalışmanın amacı, KTEPH tanılı hastalarda ameliyat öncesi klinik ve hemodinamik parametreler ile V/Q tek foton emisyon tomografisi/bilgisayarlı tomografideki (SPECT/BT) Q defektlerinin yaygınlığı arasındaki korelasyonu araştırmaktır.Yöntem: PEA ile tanısı doğrulanmış 102 KTEPH hastasının PEA öncesi V/Q SPECT/BT görüntüleri retrospektif olarak incelendi. PEA öncesi yaş, cinsiyet, New York Kalp Derneği sınıfı, intraoperatif sağ kalp kateterizasyonu sonuçları [ortalama pulmoner arter basıncı (OPAB), pulmoner vasküler rezistans (PVR)] ve 6 dakikalık yürüme testi (6DYT) gibi klinik parametreleri hastaların klinik kayıtlarından elde edildi.Bulgular: Doğrusal regresyon analizi, preoperative OPAB ve PVR ile V/Q SPECT/BT’deki eşleşmeyen Q defektlerinin yaygınlığı ile anlamlı ancak zayıf bir korelasyon gösterdi (rs=0,09474, p=0,0016; rs=0,045, p=0,045). 6DYT mesafesi ile eşleşmeyen Q defektlerinin yaygınlığı arasında ise anlamlı bir ilişki bulunmadı (p>0,05).Sonuç: V/Q SPECT/BT’de saptanan Q defektlerinin kantitatif değerlendirilmesi, KTEPH tanılı hastalarda hemodinamik parametreler hakkında fikir sağlayabilir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Özgüven S, Kesim S, Öksüzoğlu K, Yanartas M, Taş s, SEN F, Ones T, Inanir S, TUROGLU H, Mutlu B, erdil t, Yıldızeli B (2021). Correlation Between Perfusion Abnormalities Extent in Ventilation/Perfusion SPECT/CT with Hemodynamic Parameters in Patients with Chronic Thromboembolic Pulmonary Hypertension. , 28 - 33. 10.4274/mirt.galenos.2020.31932
Chicago	Özgüven Salih,Kesim Selin,Öksüzoğlu Kevser,Yanartas Mehmed,Taş serpil,SEN FEYZA,Ones Tunc,Inanir Sabahat,TUROGLU Halil Turgut,Mutlu Bulent,erdil tanju yusuf,Yıldızeli Bedrettin Correlation Between Perfusion Abnormalities Extent in Ventilation/Perfusion SPECT/CT with Hemodynamic Parameters in Patients with Chronic Thromboembolic Pulmonary Hypertension. (2021): 28 - 33. 10.4274/mirt.galenos.2020.31932
MLA	Özgüven Salih,Kesim Selin,Öksüzoğlu Kevser,Yanartas Mehmed,Taş serpil,SEN FEYZA,Ones Tunc,Inanir Sabahat,TUROGLU Halil Turgut,Mutlu Bulent,erdil tanju yusuf,Yıldızeli Bedrettin Correlation Between Perfusion Abnormalities Extent in Ventilation/Perfusion SPECT/CT with Hemodynamic Parameters in Patients with Chronic Thromboembolic Pulmonary Hypertension. , 2021, ss.28 - 33. 10.4274/mirt.galenos.2020.31932
AMA	Özgüven S,Kesim S,Öksüzoğlu K,Yanartas M,Taş s,SEN F,Ones T,Inanir S,TUROGLU H,Mutlu B,erdil t,Yıldızeli B Correlation Between Perfusion Abnormalities Extent in Ventilation/Perfusion SPECT/CT with Hemodynamic Parameters in Patients with Chronic Thromboembolic Pulmonary Hypertension. . 2021; 28 - 33. 10.4274/mirt.galenos.2020.31932
Vancouver	Özgüven S,Kesim S,Öksüzoğlu K,Yanartas M,Taş s,SEN F,Ones T,Inanir S,TUROGLU H,Mutlu B,erdil t,Yıldızeli B Correlation Between Perfusion Abnormalities Extent in Ventilation/Perfusion SPECT/CT with Hemodynamic Parameters in Patients with Chronic Thromboembolic Pulmonary Hypertension. . 2021; 28 - 33. 10.4274/mirt.galenos.2020.31932
IEEE	Özgüven S,Kesim S,Öksüzoğlu K,Yanartas M,Taş s,SEN F,Ones T,Inanir S,TUROGLU H,Mutlu B,erdil t,Yıldızeli B "Correlation Between Perfusion Abnormalities Extent in Ventilation/Perfusion SPECT/CT with Hemodynamic Parameters in Patients with Chronic Thromboembolic Pulmonary Hypertension." , ss.28 - 33, 2021. 10.4274/mirt.galenos.2020.31932
ISNAD	Özgüven, Salih vd. "Correlation Between Perfusion Abnormalities Extent in Ventilation/Perfusion SPECT/CT with Hemodynamic Parameters in Patients with Chronic Thromboembolic Pulmonary Hypertension". (2021), 28-33. https://doi.org/10.4274/mirt.galenos.2020.31932

APA	Özgüven S, Kesim S, Öksüzoğlu K, Yanartas M, Taş s, SEN F, Ones T, Inanir S, TUROGLU H, Mutlu B, erdil t, Yıldızeli B (2021). Correlation Between Perfusion Abnormalities Extent in Ventilation/Perfusion SPECT/CT with Hemodynamic Parameters in Patients with Chronic Thromboembolic Pulmonary Hypertension. Molecular Imaging and Radionuclide Therapy, 30(1), 28 - 33. 10.4274/mirt.galenos.2020.31932
Chicago	Özgüven Salih,Kesim Selin,Öksüzoğlu Kevser,Yanartas Mehmed,Taş serpil,SEN FEYZA,Ones Tunc,Inanir Sabahat,TUROGLU Halil Turgut,Mutlu Bulent,erdil tanju yusuf,Yıldızeli Bedrettin Correlation Between Perfusion Abnormalities Extent in Ventilation/Perfusion SPECT/CT with Hemodynamic Parameters in Patients with Chronic Thromboembolic Pulmonary Hypertension. Molecular Imaging and Radionuclide Therapy 30, no.1 (2021): 28 - 33. 10.4274/mirt.galenos.2020.31932
MLA	Özgüven Salih,Kesim Selin,Öksüzoğlu Kevser,Yanartas Mehmed,Taş serpil,SEN FEYZA,Ones Tunc,Inanir Sabahat,TUROGLU Halil Turgut,Mutlu Bulent,erdil tanju yusuf,Yıldızeli Bedrettin Correlation Between Perfusion Abnormalities Extent in Ventilation/Perfusion SPECT/CT with Hemodynamic Parameters in Patients with Chronic Thromboembolic Pulmonary Hypertension. Molecular Imaging and Radionuclide Therapy, vol.30, no.1, 2021, ss.28 - 33. 10.4274/mirt.galenos.2020.31932
AMA	Özgüven S,Kesim S,Öksüzoğlu K,Yanartas M,Taş s,SEN F,Ones T,Inanir S,TUROGLU H,Mutlu B,erdil t,Yıldızeli B Correlation Between Perfusion Abnormalities Extent in Ventilation/Perfusion SPECT/CT with Hemodynamic Parameters in Patients with Chronic Thromboembolic Pulmonary Hypertension. Molecular Imaging and Radionuclide Therapy. 2021; 30(1): 28 - 33. 10.4274/mirt.galenos.2020.31932
Vancouver	Özgüven S,Kesim S,Öksüzoğlu K,Yanartas M,Taş s,SEN F,Ones T,Inanir S,TUROGLU H,Mutlu B,erdil t,Yıldızeli B Correlation Between Perfusion Abnormalities Extent in Ventilation/Perfusion SPECT/CT with Hemodynamic Parameters in Patients with Chronic Thromboembolic Pulmonary Hypertension. Molecular Imaging and Radionuclide Therapy. 2021; 30(1): 28 - 33. 10.4274/mirt.galenos.2020.31932
IEEE	Özgüven S,Kesim S,Öksüzoğlu K,Yanartas M,Taş s,SEN F,Ones T,Inanir S,TUROGLU H,Mutlu B,erdil t,Yıldızeli B "Correlation Between Perfusion Abnormalities Extent in Ventilation/Perfusion SPECT/CT with Hemodynamic Parameters in Patients with Chronic Thromboembolic Pulmonary Hypertension." Molecular Imaging and Radionuclide Therapy, 30, ss.28 - 33, 2021. 10.4274/mirt.galenos.2020.31932
ISNAD	Özgüven, Salih vd. "Correlation Between Perfusion Abnormalities Extent in Ventilation/Perfusion SPECT/CT with Hemodynamic Parameters in Patients with Chronic Thromboembolic Pulmonary Hypertension". Molecular Imaging and Radionuclide Therapy 30/1 (2021), 28-33. https://doi.org/10.4274/mirt.galenos.2020.31932