Effectiveness of Lactate Dehydrogenase to Albumin Ratio in the Diagnosis of Pulmonary Thromboembolism

YALÇIN, Kadir Serkan; KÜÇÜKAY, Murat Bülent; ALANLI, Recep

doi:10.5222/BMJ.2021.81905

Effectiveness of Lactate Dehydrogenase to Albumin Ratio in the Diagnosis of Pulmonary Thromboembolism

Recep ALANLI, (Lokman Hekim Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Murat Bülent KÜÇÜKAY, (Lokman Hekim Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Kadir Serkan YALÇIN (Lokman Hekim Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Bakırköy Tıp Dergisi

6 1

Yıl: 2021 Cilt: 17 Sayı: 1 Sayfa Aralığı: 25 - 29 Metin Dili: İngilizce DOI: 10.5222/BMJ.2021.81905 İndeks Tarihi: 20-05-2021

Effectiveness of Lactate Dehydrogenase to Albumin Ratio in the Diagnosis of Pulmonary Thromboembolism

Öz:

Objective: The aim of the study is to inspect effectiveness of lactate dehydrogenase (LDH) to albumin ratio (LAR) in patients with pulmonary thromboembolism (PTE).Method: A total of 307 patients who admitted to emergency unit, between January 2017 and March 2020, with chest pain and sudden onset of dyspnea were enrolled in this single- center and retrospective study. Computed tomography pulmonary angiogram (CTPA) was performed to confirm pulmonary embolism.Results: LAR, neutrophil, monocyte, D-dimer, LDH values were significantly higher and albumin values were significantly lower in patients with pulmonary embolism compared to those without. Average age of 307 participants were 68.93 years. While 140 patients had confirmed PTE and 167 were without PTE. Linear regression analysis for LAR in the diagnosis of PTE, revealed a correlation coefficient as r=0.320 (p<0.001). Positive and negative predictive values for LAR in the diagnosisi of PTE were, 63.3% and 75.2%, respectively. In ROC analysis relation of LAR to PTE was found to be stronger than LDH and albumin alone.Conclusion: LAR, which is a very simple and available test, may be used as a novel parameter in the diagnosis of PTE.

Anahtar Kelime:

Laktat Dehidrojenaz Albumin Oranının Pulmoner Emboli Tanısında Etkinliği

Öz:

Amaç: Bu çalışmanın amacı laktat dehidrojenaz albumin oranının (LAR) pulmoner tromboemboli (PTE) tanısındaki etkinliğini incelemektir.Yöntem: Bu tek merkezli, retrospektif çalışmada, Ocak 2017 ile Mart 2020 tarihleri arasında acil servise göğüs ağrısı ve ani gelişen dispne nedeniyle başvuran ve PTE şüphesi ile PBTA yapılmış olan 307 hasta incelendi.Bulgular: PTE saptanan hastalarda, PTE saptanmayan hastalarla kıyaslandığında; LAR, nötrofil ve monosit sayımları, d-dimer ve LDH değerleri anlamlı olarak yüksek bulunurken, albumin değerleri anlamlı olarak daha düşük bulundu. Katılımcıların ortalama yaşı 68,93 olarak bulundu; 140 hastada PTE saptanırken 167'sinde PTE saptanmadı. LAR ile PTE arasındaki lineer regresyon analizinde korrelasyon katsayısı r=0,320. LAR için pozitif prediktif değer %63,3, negatif prediktif değer %75,2 olarak bulundu. Receiver operator characteristics (ROC) eğrisi incelemesinde LAR ile PTE arasındaki ilişki, tek başına LDH veya albumin testlerinden daha güçlü bulunmuştur.Sonuç: Basit ve her yerde yapılabilir bir test olarak LAR, PTE tanısında yeni bir parametre olarak kullanılabilir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ALANLI R, KÜÇÜKAY M, YALÇIN K (2021). Effectiveness of Lactate Dehydrogenase to Albumin Ratio in the Diagnosis of Pulmonary Thromboembolism. , 25 - 29. 10.5222/BMJ.2021.81905
Chicago	ALANLI Recep,KÜÇÜKAY Murat Bülent,YALÇIN Kadir Serkan Effectiveness of Lactate Dehydrogenase to Albumin Ratio in the Diagnosis of Pulmonary Thromboembolism. (2021): 25 - 29. 10.5222/BMJ.2021.81905
MLA	ALANLI Recep,KÜÇÜKAY Murat Bülent,YALÇIN Kadir Serkan Effectiveness of Lactate Dehydrogenase to Albumin Ratio in the Diagnosis of Pulmonary Thromboembolism. , 2021, ss.25 - 29. 10.5222/BMJ.2021.81905
AMA	ALANLI R,KÜÇÜKAY M,YALÇIN K Effectiveness of Lactate Dehydrogenase to Albumin Ratio in the Diagnosis of Pulmonary Thromboembolism. . 2021; 25 - 29. 10.5222/BMJ.2021.81905
Vancouver	ALANLI R,KÜÇÜKAY M,YALÇIN K Effectiveness of Lactate Dehydrogenase to Albumin Ratio in the Diagnosis of Pulmonary Thromboembolism. . 2021; 25 - 29. 10.5222/BMJ.2021.81905
IEEE	ALANLI R,KÜÇÜKAY M,YALÇIN K "Effectiveness of Lactate Dehydrogenase to Albumin Ratio in the Diagnosis of Pulmonary Thromboembolism." , ss.25 - 29, 2021. 10.5222/BMJ.2021.81905
ISNAD	ALANLI, Recep vd. "Effectiveness of Lactate Dehydrogenase to Albumin Ratio in the Diagnosis of Pulmonary Thromboembolism". (2021), 25-29. https://doi.org/10.5222/BMJ.2021.81905

APA	ALANLI R, KÜÇÜKAY M, YALÇIN K (2021). Effectiveness of Lactate Dehydrogenase to Albumin Ratio in the Diagnosis of Pulmonary Thromboembolism. Bakırköy Tıp Dergisi, 17(1), 25 - 29. 10.5222/BMJ.2021.81905
Chicago	ALANLI Recep,KÜÇÜKAY Murat Bülent,YALÇIN Kadir Serkan Effectiveness of Lactate Dehydrogenase to Albumin Ratio in the Diagnosis of Pulmonary Thromboembolism. Bakırköy Tıp Dergisi 17, no.1 (2021): 25 - 29. 10.5222/BMJ.2021.81905
MLA	ALANLI Recep,KÜÇÜKAY Murat Bülent,YALÇIN Kadir Serkan Effectiveness of Lactate Dehydrogenase to Albumin Ratio in the Diagnosis of Pulmonary Thromboembolism. Bakırköy Tıp Dergisi, vol.17, no.1, 2021, ss.25 - 29. 10.5222/BMJ.2021.81905
AMA	ALANLI R,KÜÇÜKAY M,YALÇIN K Effectiveness of Lactate Dehydrogenase to Albumin Ratio in the Diagnosis of Pulmonary Thromboembolism. Bakırköy Tıp Dergisi. 2021; 17(1): 25 - 29. 10.5222/BMJ.2021.81905
Vancouver	ALANLI R,KÜÇÜKAY M,YALÇIN K Effectiveness of Lactate Dehydrogenase to Albumin Ratio in the Diagnosis of Pulmonary Thromboembolism. Bakırköy Tıp Dergisi. 2021; 17(1): 25 - 29. 10.5222/BMJ.2021.81905
IEEE	ALANLI R,KÜÇÜKAY M,YALÇIN K "Effectiveness of Lactate Dehydrogenase to Albumin Ratio in the Diagnosis of Pulmonary Thromboembolism." Bakırköy Tıp Dergisi, 17, ss.25 - 29, 2021. 10.5222/BMJ.2021.81905
ISNAD	ALANLI, Recep vd. "Effectiveness of Lactate Dehydrogenase to Albumin Ratio in the Diagnosis of Pulmonary Thromboembolism". Bakırköy Tıp Dergisi 17/1 (2021), 25-29. https://doi.org/10.5222/BMJ.2021.81905