Beta-laktam Antibiyotiklere Karşı Gelişen Aşırı Duyarlılık Reaksiyonları

Demirkan, Kutay; Göncüoğlu, Cansu; Unal, Serhat; Kalyoncu, Ali Fuat; KARA, Emre

doi:10.5578/flora.20219903

Beta-laktam Antibiyotiklere Karşı Gelişen Aşırı Duyarlılık Reaksiyonları

Cansu GÖNCÜOĞLU, (Hacettepe Üniversitesi, Eczacılık Fakültesi, Klinik Eczacılık Anabilim Dalı, Ankara, Türkiye)

Emre KARA, (Hacettepe Üniversitesi, Eczacılık Fakültesi, Klinik Eczacılık Anabilim Dalı, Ankara, Türkiye)

Kutay DEMİRKAN, (Hacettepe Üniversitesi, Eczacılık Fakültesi, Klinik Eczacılık Anabilim Dalı, Ankara, Türkiye)

Ali Fuat KALYONCU, (Hacettepe Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Allerjik ve İmmünolojik Hastalıklar Bilim Dalı, Ankara, Türkiye)

Serhat ÜNAL (Hacettepe Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye)

Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

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Yıl: 2021 Cilt: 26 Sayı: 1 Sayfa Aralığı: 23 - 33 Metin Dili: Türkçe DOI: 10.5578/flora.20219903 İndeks Tarihi: 20-05-2021

Beta-laktam Antibiyotiklere Karşı Gelişen Aşırı Duyarlılık Reaksiyonları

Öz:

Beta-laktam antibiyotiklerin kullanımı ile aşırı duyarlılık reaksiyonu ortaya çıkma olasılığı %5-18 arasında değişmektedir. Beta-laktam aşırı duyarlılığı olan hastalarda diğer antibiyotik gruplarının reçetelenme eğilimi, dirençli mikroorganizma insidansındaki artışın yanı sıra sağlık bakımı maliyetinde ve reçetelenen diğer ilaç gruplarından kaynaklanan advers etkilerde artışa neden olmaktadır. Hasta tıbbi kayıtlarında bulunan ancak doğrulanmamış aşırı duyarlılık öyküleri nedeniyle, penisilin ve sefalosporinlerin kullanımından kaçınıldığı, dirençli infeksiyonların görülme sıklığının arttığı ve antibiyotik direncinin bu durumdan olumsuz etkilendiği saptanmıştır. Yapılan az sayıda çalışmaya göre beta-laktam antibiyotiklerin uygulama yolu, aşırı duyarlılık reaksiyonu gelişme riski açısından önemli bir farka neden olmamakla birlikte, oral uygulamada parenteral uygulamaya göre aşırı duyarlılık reaksiyonları ve anafilaksinin daha nadir görüldüğü bildirilmiştir.

Anahtar Kelime:

Hypersensitivity Reactions to Beta-lactam Antibiotics

Öz:

The incidence of hypersensitivity reaction with the use of beta-lactam antibiotics ranges from 5-18%. The prescribing tendency of other antibiotic groups in patients with beta-lactam hypersensitivity causes an increase in the incidence of resistant microorganism, health care costs and adverse effects from other prescribed drug groups. Due to the history of unverified hypersensitivity of the patient, the use of penicillin and cephalosporins was avoided, the incidence of resistant infections and antibiotic resistance increased. According to a few studies conducted, the route of administration of beta-lactam antibiotics does not cause a significant difference in terms of the risk of developing hypersensitivity reaction. However, hypersensitivity reactions and anaphylaxis have been reported rarely in oral administra-tion compared to parenteral administration.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	Göncüoğlu C, KARA E, Demirkan K, Kalyoncu A, Unal S (2021). Beta-laktam Antibiyotiklere Karşı Gelişen Aşırı Duyarlılık Reaksiyonları. , 23 - 33. 10.5578/flora.20219903
Chicago	Göncüoğlu Cansu,KARA Emre,Demirkan Kutay,Kalyoncu Ali Fuat,Unal Serhat Beta-laktam Antibiyotiklere Karşı Gelişen Aşırı Duyarlılık Reaksiyonları. (2021): 23 - 33. 10.5578/flora.20219903
MLA	Göncüoğlu Cansu,KARA Emre,Demirkan Kutay,Kalyoncu Ali Fuat,Unal Serhat Beta-laktam Antibiyotiklere Karşı Gelişen Aşırı Duyarlılık Reaksiyonları. , 2021, ss.23 - 33. 10.5578/flora.20219903
AMA	Göncüoğlu C,KARA E,Demirkan K,Kalyoncu A,Unal S Beta-laktam Antibiyotiklere Karşı Gelişen Aşırı Duyarlılık Reaksiyonları. . 2021; 23 - 33. 10.5578/flora.20219903
Vancouver	Göncüoğlu C,KARA E,Demirkan K,Kalyoncu A,Unal S Beta-laktam Antibiyotiklere Karşı Gelişen Aşırı Duyarlılık Reaksiyonları. . 2021; 23 - 33. 10.5578/flora.20219903
IEEE	Göncüoğlu C,KARA E,Demirkan K,Kalyoncu A,Unal S "Beta-laktam Antibiyotiklere Karşı Gelişen Aşırı Duyarlılık Reaksiyonları." , ss.23 - 33, 2021. 10.5578/flora.20219903
ISNAD	Göncüoğlu, Cansu vd. "Beta-laktam Antibiyotiklere Karşı Gelişen Aşırı Duyarlılık Reaksiyonları". (2021), 23-33. https://doi.org/10.5578/flora.20219903

APA	Göncüoğlu C, KARA E, Demirkan K, Kalyoncu A, Unal S (2021). Beta-laktam Antibiyotiklere Karşı Gelişen Aşırı Duyarlılık Reaksiyonları. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 26(1), 23 - 33. 10.5578/flora.20219903
Chicago	Göncüoğlu Cansu,KARA Emre,Demirkan Kutay,Kalyoncu Ali Fuat,Unal Serhat Beta-laktam Antibiyotiklere Karşı Gelişen Aşırı Duyarlılık Reaksiyonları. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi 26, no.1 (2021): 23 - 33. 10.5578/flora.20219903
MLA	Göncüoğlu Cansu,KARA Emre,Demirkan Kutay,Kalyoncu Ali Fuat,Unal Serhat Beta-laktam Antibiyotiklere Karşı Gelişen Aşırı Duyarlılık Reaksiyonları. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, vol.26, no.1, 2021, ss.23 - 33. 10.5578/flora.20219903
AMA	Göncüoğlu C,KARA E,Demirkan K,Kalyoncu A,Unal S Beta-laktam Antibiyotiklere Karşı Gelişen Aşırı Duyarlılık Reaksiyonları. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi. 2021; 26(1): 23 - 33. 10.5578/flora.20219903
Vancouver	Göncüoğlu C,KARA E,Demirkan K,Kalyoncu A,Unal S Beta-laktam Antibiyotiklere Karşı Gelişen Aşırı Duyarlılık Reaksiyonları. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi. 2021; 26(1): 23 - 33. 10.5578/flora.20219903
IEEE	Göncüoğlu C,KARA E,Demirkan K,Kalyoncu A,Unal S "Beta-laktam Antibiyotiklere Karşı Gelişen Aşırı Duyarlılık Reaksiyonları." Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 26, ss.23 - 33, 2021. 10.5578/flora.20219903
ISNAD	Göncüoğlu, Cansu vd. "Beta-laktam Antibiyotiklere Karşı Gelişen Aşırı Duyarlılık Reaksiyonları". Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi 26/1 (2021), 23-33. https://doi.org/10.5578/flora.20219903