Ersin DEMERİ
(Adnan Menderes Üniversitesi, Tıp Fakültesi, Nöroloji Bölümü, Aydın, Türkiye)
Nesibe TİLEK
(Adnan Menderes Üniversitesi, Tıp Fakültesi, Nöroloji Bölümü, Aydın, Türkiye)
Aysel ESEN ÇOBAN
(Adnan Menderes Üniversitesi, Tıp Fakültesi, Klinik Nöroloji Bölümü, Aydın, Türkiye)
Cengiz TATAROĞLU
(Adnan Menderes Üniversitesi, Tıp Fakültesi, Klinik Nörofizyoloji Bölümü, Aydın, Türkiye)
Yıl: 2020Cilt: 37Sayı: 4ISSN: 1300-1817 / 2636-865XSayfa Aralığı: 164 - 169İngilizce

20 0
Long Latency Reflexes in Patients with Postural Instability and Ataxia
Objectives: Distal electrical stimulation of an upper extremity mixed nerve can generate a reflex response from the trapezius muscle. This reflex response may have a central neural pathway and can be affected by postural changes. Materials and Methods: In this study, long latency reflexes (LLRs) from both distal and trapezius muscle were evaluated in patients with Parkinson’s disease (PD) with and without postural dysfunction and in patients with cerebellar ataxias. Thirty-three patients with PD, 10 patients with degenerative cerebellar ataxia and 22 healthy volunteers were included in the study. LLRs were recorded from ipsilateral thenar and trapezius muscles. Latencies and amplitudes of LLRs obtained from thenar (thenar LLR) and trapezius (trapezius LLR) muscles were analyzed. Results: In patients with PD, thenar LLRs showed significant shortening in the onset latencies and significant increase in the amplitudes in comparison with healthy controls. Trapezius LLRs did not show any significant difference in latencies or amplitudes; however, these responses showed a significant absence in one or two components in patients with Parkinson’s disease with postural dysfunction. Additionally, this reflex was not recorded in patients with cerebellar ataxia. Conclusion: Trapezius LLRs can give some information regarding the physiology of neural circuits responsible for postural arrangement. Cerebellar connections may have a major role in the generation of trapezius LLRs.
DergiDiğerErişime Açık
  • Tataroglu C, Kuçuk FK, Ozkul A. Upper and lower extremity proprioceptive inputs modulate EMG activity of the trapezius. J Electromyogr Kinesiol 2011;21:77‑81.
  • 2. Cruccu G, Deuschl G. the clinical use of brainstem reflexes and hand‑muscle reflexes. Clin Neurophysiol 2000;111:371‑87.
  • 3. Tataroglu C, Sair A, Parlaz A, Deneri E. Effects of 1‑hz repetitive transcranial magnetic stimulation on long‑latency reflexes and cortical relay time. J Clin Neurophysiol 2011;28:319-22.
  • 4. Tsuji T, Rothwell JC. Long lasting effects of rTMS and associated peripheral sensory input on MEPs, SEPs and transcortical reflex excitability in humans. J Physiol 2002;540:367‑76.
  • 5. Tataroglu C, Genc A, Idiman E, Cakmur R, Idiman F. Cortical relay time for long latency reflexes in patients with definite multiple sclerosis. Can J Neurol Sci 2004;31:229-34.
  • 6. Mori F, Okada KI, Nomura T, Kobayashi Y. The pedunculopontine tegmental nucleus as a motor and cognitive interface between the cerebellum and basal ganglia. Front Neuroanat 2016;10:109.
  • 7. Müller ML, Albin RL, Kotagal V, Koeppe RA, Scott PJ, Frey KA, et al. Thalamic cholinergic innervations and postural integration function in Parkinson’s disease. Brain 2013;136:3282‑9.
  • 8. Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, et al. MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord 2015;30:1591-9.
  • 9. Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez‑Martin P, et al. Movement disorder society UPDRS revision task force. Movement disorder society‑sponsored revision of the unified Parkinson’s disease rating scale (MDSUPDRS): Scale presentation and clinimetric testing results. Mov Disord 2008;23:2129-70.
  • 10. Dimitrova D, Horak FB, Nutt JG. Postural muscle responses to multidirectional translations in patients with Parkinson’s disease. J Neurophysiol 2004;91:489-501.
  • 11. Alexander CM, Harrison PJ. Reflex connections from forearm and hand afferents to shoulder girdle muscles in humans. Exp Brain Res 2003;148:277‑82.
  • 12. Claus D, Schöcklmann HO, Dietrich HJ. Long latency stretch responses in cerebellar diseases. Eur Arch Psychiatry Neurol Sci 1986;235:355-60.
  • 13. Wu T, Hallett M. The cerebellum in Parkinson’s disease. Brain 2013;136:696-709.
  • 14. Muller ML, Bohnen NI. Cholinergic dysfunction in Parkinson’s disease. Curr Neurol Neurosci Rep 2013;13:377‑9.
  • 15. Lee RG, Tatton WG. Motor responses to sudden limb displacements in primates with specific CNS lesions and in human patients with motor system disorders. Can J Neurol Sci 1975;2:285-93.
  • 16. Berardelli A, Sabra AF, Hallett M. Physiological mechanisms of rigidity in Parkinson’s disease. J Neurol Neurosurg Psychiatry 1983;46:45-53.
  • 17. Rothwell JC, Obeso JA, Traub MM, Marsden CD. The behaviour of the long‑latency stretch reflex in patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry 1983;46:35‑44.
  • 18. Yavuz D, Gündüz A, Ertan S, Apaydın H, Sifoglu A, Kiziltan G, et al. Specific brainstem and cortico‑spinal reflex abnormalities in coexisting essential tremor and Parkinson’s disease (ET‑PD). Neurophysiol Clin 2015;45:143-9.
  • 19. Tatton WG, Bedingham W, Verrier MC, Blair RD. Characteristic alterations in responses to imposed wrist displacements in Parkinsonian rigidity and dystonia musculorum deformans. Can J Neurol Sci 1984;11:281-7.
  • 20. Haslinger B, Erhard P, Kämpfe N, Boecker H, Rummeny E, Schwaiger M, et al. Event-related functional magnetic resonance imaging in Parkinson’s disease before and after levodopa. Brain 2001;124:558-70.
  • 21. Marchand‑Pauvert V, Gerdelat‑Mas A, Ory‑Magne F, Calvas F, Mazevet D, Meunier S, et al. Both L‑DOPA and HFS‑STN restore the enhanced group ii spinal reflex excitation to a normal level in patients with Parkinson’s disease. Clin Neurophysiol 2011;122:1019-26.
  • 22. Simonetta Moreau M, Meunier S, Vidailhet M, Pol S, Galitzky M, Rascol O. Transmission of group II heteronymous pathways is enhanced in rigid lower limb of de novo patients with Parkinson’s disease. Brain 2002;125:2125‑33.
  • 23. Pasquereau B, Turner RS. Primary motor cortex of the parkinsonian monkey: altered neuronal responses to muscle stretch. Frontiers Syst Neurosci 2013:7;1-14.
  • 24. Abbruzzese G, Berardelli A. Sensorimotor integration in movement disorders. Mov Disord 2003;18:231-40.
  • 25. Kandler RH, Jarratt JA, Sagar HJ, Gumpert EJ, Venables GS, Davies‑Jones GA, et al. Abnormalities of central motor conduction in Parkinson’s disease. J Neurol Sci 1990;100:94‑7.
  • 26. Valls‑Solé J, Pascual‑Leone A, Brasil‑Neto JP, Cammarota A, Mcshane L, Hallett M. Abnormal facilitation of the response to transcranial magnetic stimulation in patients with Parkinson’s disease. Neurology 1994;44:735-41.
  • 27. Tremblay F, Tremblay LE. Cortico‑motor excitability of the lower limb motor representation: A comparative study in Parkinson’s disease and healthy controls. Clin Neurophysiol 2002;113:2006-12.
  • 28. Lou JS, Benice T, Kearns G, Sexton G, Nutt J. Levodopa normalizes exercise related cortico‑motoneuron excitability abnormalities in Parkinson’s disease. Clin Neurophysiol 2003;114:930-7.
  • 29. Lefaucheur JP. Motor cortex dysfunction revelaed by cortical excitability studies in Parkinson’s disease: Influence of antiparkinsonian treatment and cortical stimulation. Clin Neurophysiol 2005;116:244-53

TÜBİTAK ULAKBİM Ulusal Akademik Ağ ve Bilgi Merkezi Cahit Arf Bilgi Merkezi © 2019 Tüm Hakları Saklıdır.