Yıl: 2020 Cilt: 23 Sayı: 3 Sayfa Aralığı: 326 - 333 Metin Dili: İngilizce DOI: 10.31086/tjgeri.2020.168 İndeks Tarihi: 26-06-2021

COURSE OF ACUTE PANCREATITIS IN THE ELDERLY EVALUATED WITH COMPUTED TOMOGRAPHY SCAN

Öz:
Introduction: In our study, we aimed to evaluate how age affects the severity and course of acute pancreatitis according to the modified Balthazar scoring system.Materials and methods: 354 patients diagnosed with acute-pancreatitis and followed-up in our hospital between July/2013-February/2019 were included our study. Demographic data, comorbid diseases and mortality rates of all patients were documented. Patients with aged 65 and over were assessed as geriatric population. Allpatientsincludedinthestudyunderwentcontrastenhancedabdominalcomputed-tomography within the first 12 hours and on days 3 to 7. According to the modified Balthazar score, patients with mild, moderate and severe acute-pancreatitis respectively. The relationship between age and computed-tomography findings was analyzed. Results: 206 (58.2%) of the patients included in the study were women. Mean age was 54.8±17.9 years (18-100 years). Geriatric population consisted of 129(36.5%) patients. There was no statistically significant difference between the two groups accordingtothemodifiedBalthazarclassificationontheinitialcomputed-tomographies on admission (p>0.05). However, on computed-tomography scans taken after the third day, severe acute-pancreatitis was detected significantly more frequently in the elderly (p<0.05). Additionally, in comparing the disease progression on computed-tomography scans, disease progression was significantly higher in the elderly group (p <0.05). In addition, comorbidity score and mortality rate were found to be significantly higher in the elderly group (p<0.001, p:0042, respectively).Conclusion: In acute pancreatitis, age may have an effect on the severity of the disease. For this reason, multidisciplinary approach and close follow-up with monitoring is crucial in geriatric patients.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Lankisch PG, Apte M, Banks PA. Acute pancreatitis. Lancet 2015;386:85–96 (PMID: 25616312).
  • 2. Singla A, Simons J, Li Y, et al. Admission volume determines outcome for patients with acute pancreatitis. Gastroenterology 2009;137: 1995–2001. (PMID: 19733570).
  • 3. Tozlu M, Kayar Y, Ince AT, Baysal B, Senturk H. Low molecular weight heparin treatment of acute moderate and severe pancreatitis: A randomized, controlled, open-label study. Turk J Gastroenterol 2019 Jan;30(1):81-7. (PMID: 30289392).
  • 4. Abu-Zidan FM, Bonham MJ, Windsor JA. Severity of acutepancreatitis: a multivariate analysis of oxidative stress markers and modified Glasgow criteria. Br J Surg 2000;87:1019–23. (PMID: 10931044).
  • 5. Goldacre MJ, Roberts SE. Hospital admission for acute pancreatitis in an English population, 1963- 98: data base study of incidence and mortality. BMJ 2004;328:1466–9. (PMID: 15205290).
  • 6. Kayar Y, Senturk H, Tozlu M, Baysal B, Atay M, Ince AT. Prediction of Self-Limited Acute Pancreatitis Cases at Admission to Emergency Unit.GE Port J Gastroenterol 2019 Jul;26(4):251-9. (PMID: 31328139).
  • 7. Gardner T.B, Santhi Swaroop V, Suresh S.T, et al. The effect of age on hospital outcomes in severe acute pancreatitis. Pancreatology 2008;8:265–70. (PMID: 18497539).
  • 8. Blamey S.L, Imrie CW, O’Neill J, Gilmour WH, Carter DC. Prognostic factors in acute pancreatitis. Gut 1984;25:1340–6. (PMID: 6510766).
  • 9. Ranson JHC, K M Rifkind, D F Roses, S D Fink, K Eng, F C Spencer. Prognostic signs and the role of operative management in acute pancreatitis. Surg Gynecol Obstet 1974;139:69–81. (PMID: 4834279).
  • 10. Wilson C, Heath D.I, Imrie C.W. Prediction of outcome in acute pancreatitis: a comparative study of APACHE II, clinical assessment and multiple factor scoring systems. Br. J. Surg 1990;77:1260–4. (PMID: 2253005).
  • 11. Nguyen BL, Thompson JS, Edney JA. Influence of the etiology of pancreatitis on the natural history of pancreatic pseudocysts. Am J Surg 1991;162:527– 530. (PMID: 1670219).
  • 12. Gullo L, Migliori M, Olah A, et al. Acute pancreatitis in five European countries. Etiol Mortality Pancreas 2002;24:223–7. (PMID: 11893928).
  • 13. Roulin D, Girardet R, Duran R, et al. Outcome of elderly patients afte acute biliary pancreatitis. Biosci Trends 2018;12:54–9. (PMID: 29553102).
  • 14. Losurdo G, Iannone A, Principi M, Barone M et al. Acute pancreatitis in elderly patients: A retrospective evaluation at hospital admission. Eur J Intern Med 2016;30:88–93. (PMID: 26806437).
  • 15. De Beaux A.C, Palmer K.R, Carter D.C, Factors influencing morbidity and mortality in acute pancreatitis: an analysis of 279 cases. Gut 1995;37:121–6. (PMID: 7672660).
  • 16. Tenner S, Baillie J, DeWitt J, Vege SS. American College of Gastroenterology. American College of Gastroenterology guideline: management of acute pancreatitis. Am J Gastroenterol 2013;108:1400-16. (PMID: 23896955).
  • 17. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987; 40(5): 373–83. (3558716).
  • 18. Balthazar EJ, Freeny PC, Van-Sonnenberg E. Imaging and intervention in acute pancreatitis. Radiology 1994;193:297-306. (PMID: 7972730).
  • 19. McKay C.J, Evans S, Sinclair M, Imrie CW. High early mortality rate from acute pancreatitis in Scotland, 1984–1995. Br. J. Surg 1999;86:1302–5. (PMID: 10540138).
  • 20. Roberts SE, Morrison-Rees S, John A, Williams JG, Brown TH, Samuel DG. The incidence and a etiology of acute pancreatitis across Europe. Pancreatology 2017;17(2):155–65. (PMID: 28159463).
  • 21. Balthazar EJ, Robinson DL, Megibow AJ, Ranson JH. Acute pancreatitis: value of CT in establishing prognosis. Radiology 1990;174:331–6. (PMID: 2296641).
  • 22. Vatansever S, Doğru R, Pakoz Z. Genc H, Unal B. Evaluation of Laboratory Findings and Mortality in Elderly Patients with Acute Biliary Pancreatitis. Med Bull Sisli Etfal Hosp 2018;52(4):274-8. (DOI: 10.14744/ SEMB.2018.37791).
  • 23. Koziel D, Gluszek-Osuch M, Suliga E, Zak M, Gluszek S. Elderly persons with acute pancreatitis–specifics of the clinical course of the disease. Clin Interv Aging 2019;14:33. (PMID: 30613137).
  • 24. Ryu J.K. Evaluation of severity in acute pancreatitis. Korean J Gastroenterol 2009;54:205–11.( PMID: 19844139).
  • 25. Cevenini E, Caruso C, Candore G, et al. Age-related inflammation: the contribution of different organs, tissues and systems. How to face it for therapeutic approaches. Curr Pharm Des 2010;16(6):609-18. (PMID: 20388071).
  • 26. Lyon C, Clark DC. Diagnosis of acute abdominal pain in older patients. Am Fam Physician 2006;74(9):1537– 44. (PMID: 17111893).
  • 27. Frossard JL, Steer ML, Pastor CM. Acute pancreatitis. Lancet 2008; 371: 143-52. (PMID: 18191686).
  • 28. Malangoni MA, Martin AS. Outcome of severe acute pancreatitis. Am J Surg 2005; 189: 273-7. (PMID: 15792749).
  • 29. Uomo G, Talamini G, Rabitti P, Cataldi F, Cavallera A, Rengo F. Influence of advanced age and related comorbidity on the course and outcome of acute pancreatitis. Ital J Gastroenterol Hepatol 1998; 30: 616–21. (PMID: 10076785).
  • 30. Quero G, Covino M, Fiorillo C, Rosa F, Menghi R, Simeoni B, Potenza A, Ojetti V, Alfieri S, Franceschi F. Acute pancreatitis in elderly patients: a singlecenter retrospective evaluation of clinical outcomes. Scand J Gastroenterol 2019 Apr; 54(4): 492-8. (PMID: 30905212)
APA KONUR Ş, SÜRMELİ AKÇADAĞ N, GÜNDÜZ İ, İLİKLERDEN Ü, Dertli R, kayar y (2020). COURSE OF ACUTE PANCREATITIS IN THE ELDERLY EVALUATED WITH COMPUTED TOMOGRAPHY SCAN. , 326 - 333. 10.31086/tjgeri.2020.168
Chicago KONUR Şevki,SÜRMELİ AKÇADAĞ NESLİHAN,GÜNDÜZ İhsan,İLİKLERDEN Ümit Haluk,Dertli Ramazan,kayar yusuf COURSE OF ACUTE PANCREATITIS IN THE ELDERLY EVALUATED WITH COMPUTED TOMOGRAPHY SCAN. (2020): 326 - 333. 10.31086/tjgeri.2020.168
MLA KONUR Şevki,SÜRMELİ AKÇADAĞ NESLİHAN,GÜNDÜZ İhsan,İLİKLERDEN Ümit Haluk,Dertli Ramazan,kayar yusuf COURSE OF ACUTE PANCREATITIS IN THE ELDERLY EVALUATED WITH COMPUTED TOMOGRAPHY SCAN. , 2020, ss.326 - 333. 10.31086/tjgeri.2020.168
AMA KONUR Ş,SÜRMELİ AKÇADAĞ N,GÜNDÜZ İ,İLİKLERDEN Ü,Dertli R,kayar y COURSE OF ACUTE PANCREATITIS IN THE ELDERLY EVALUATED WITH COMPUTED TOMOGRAPHY SCAN. . 2020; 326 - 333. 10.31086/tjgeri.2020.168
Vancouver KONUR Ş,SÜRMELİ AKÇADAĞ N,GÜNDÜZ İ,İLİKLERDEN Ü,Dertli R,kayar y COURSE OF ACUTE PANCREATITIS IN THE ELDERLY EVALUATED WITH COMPUTED TOMOGRAPHY SCAN. . 2020; 326 - 333. 10.31086/tjgeri.2020.168
IEEE KONUR Ş,SÜRMELİ AKÇADAĞ N,GÜNDÜZ İ,İLİKLERDEN Ü,Dertli R,kayar y "COURSE OF ACUTE PANCREATITIS IN THE ELDERLY EVALUATED WITH COMPUTED TOMOGRAPHY SCAN." , ss.326 - 333, 2020. 10.31086/tjgeri.2020.168
ISNAD KONUR, Şevki vd. "COURSE OF ACUTE PANCREATITIS IN THE ELDERLY EVALUATED WITH COMPUTED TOMOGRAPHY SCAN". (2020), 326-333. https://doi.org/10.31086/tjgeri.2020.168
APA KONUR Ş, SÜRMELİ AKÇADAĞ N, GÜNDÜZ İ, İLİKLERDEN Ü, Dertli R, kayar y (2020). COURSE OF ACUTE PANCREATITIS IN THE ELDERLY EVALUATED WITH COMPUTED TOMOGRAPHY SCAN. Türk Geriatri Dergisi, 23(3), 326 - 333. 10.31086/tjgeri.2020.168
Chicago KONUR Şevki,SÜRMELİ AKÇADAĞ NESLİHAN,GÜNDÜZ İhsan,İLİKLERDEN Ümit Haluk,Dertli Ramazan,kayar yusuf COURSE OF ACUTE PANCREATITIS IN THE ELDERLY EVALUATED WITH COMPUTED TOMOGRAPHY SCAN. Türk Geriatri Dergisi 23, no.3 (2020): 326 - 333. 10.31086/tjgeri.2020.168
MLA KONUR Şevki,SÜRMELİ AKÇADAĞ NESLİHAN,GÜNDÜZ İhsan,İLİKLERDEN Ümit Haluk,Dertli Ramazan,kayar yusuf COURSE OF ACUTE PANCREATITIS IN THE ELDERLY EVALUATED WITH COMPUTED TOMOGRAPHY SCAN. Türk Geriatri Dergisi, vol.23, no.3, 2020, ss.326 - 333. 10.31086/tjgeri.2020.168
AMA KONUR Ş,SÜRMELİ AKÇADAĞ N,GÜNDÜZ İ,İLİKLERDEN Ü,Dertli R,kayar y COURSE OF ACUTE PANCREATITIS IN THE ELDERLY EVALUATED WITH COMPUTED TOMOGRAPHY SCAN. Türk Geriatri Dergisi. 2020; 23(3): 326 - 333. 10.31086/tjgeri.2020.168
Vancouver KONUR Ş,SÜRMELİ AKÇADAĞ N,GÜNDÜZ İ,İLİKLERDEN Ü,Dertli R,kayar y COURSE OF ACUTE PANCREATITIS IN THE ELDERLY EVALUATED WITH COMPUTED TOMOGRAPHY SCAN. Türk Geriatri Dergisi. 2020; 23(3): 326 - 333. 10.31086/tjgeri.2020.168
IEEE KONUR Ş,SÜRMELİ AKÇADAĞ N,GÜNDÜZ İ,İLİKLERDEN Ü,Dertli R,kayar y "COURSE OF ACUTE PANCREATITIS IN THE ELDERLY EVALUATED WITH COMPUTED TOMOGRAPHY SCAN." Türk Geriatri Dergisi, 23, ss.326 - 333, 2020. 10.31086/tjgeri.2020.168
ISNAD KONUR, Şevki vd. "COURSE OF ACUTE PANCREATITIS IN THE ELDERLY EVALUATED WITH COMPUTED TOMOGRAPHY SCAN". Türk Geriatri Dergisi 23/3 (2020), 326-333. https://doi.org/10.31086/tjgeri.2020.168