Are Dogs and Cats Possible Reservoirs for Human Q Fever in Iran?

Q fever caused by Coxiella burnetii is a zoonosis of public he-alth concern, primarily transmitted by ruminants and other potential animal species. Dogs and cats have been previously implicated in the transmission of the infection; however, their involvement in the epidemiology of Q fever has been poorly investigated. Therefore, in this study, the occurrence of C. bur-netii was investigated in dogs (n=81) and cats (n=28) subjec-ted to ovariohysterectomy or vaginal swab sampling. C. bur-netii was detected by nested trans-polymerase chain reaction assay in 5 uterine samples of both dogs and cats (i.e., 12.1% and 17.8%, respectively) as well as in 8 of 40 (20%) vaginal samples of dogs. The presence of C. burnetii was determined in 18 of 109 (16.5%) samples. The genital tract of dogs and cats can harbor C. burnetii, and these animals may be considered as a source of infection. Therefore, Q fever should be conside-red a notable public health threat in Iran, and the pet owners should be made aware of the zoonotic potential of C. burnetii.

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Abiri, Z., Khalili, M., Kostoulas, P., Sharifi, H., Rad, M., Babaei, H., 2019. Bayesian estimation of sensitivity and specificity of a pcr method to detect Coxiella burnetii in milk and vaginal secretions in sheep and goat samples. Journal of Dairy Science 102, 4954-4959. [Crossref]
Agerholm, J.S., 2013. Coxiella burnetii associated reproductive disorders in domestic animals-a critical review. Acta Veterinaria Scandinavica 55, 13. [Crossref]
Berri, M., Laroucau, K., Rodolakis, A., 2000. The detection of Coxiella burnetii from ovine genital swabs, milk and fecal samples by the use of a single touchdown polymerase chain reaction. Veterinary Microbiology 72, 285-293. [Crossref]
Berri, M., Souriau, A., Crosby, M., Crochet, D., Lechopier, P., Rodolakis, A., 2001. Relationships between the shedding of Coxiella burnetii, clinical signs and serological responses of 34 sheep. The Veterinary Record 148, 502-505. [Crossref]
Brouqui, P., Marrie, T., Raoult, D., 2007. Coxiella. Manual of Clinical Microbiology. ASM Press Washington pp. 1062-1069.
Buhariwalla, F., Cann, B., Marrie, T.J., 1996. A dog-related outbreak of Q fever. Clinical Infectious Diseases 23, 753-755. [Crossref]
Cairns, K., Brewer, M., Lappin, M.R., 2007. Prevalence of Coxiella burnetii DNA in vaginal and uterine samples from healthy cats of north-central colorado. Journal of Feline Medicine and Surgery 9, 196-201. [Crossref]
Cantas, H., Muwonge, A., Sareyyupoglu, B., Yardimci, H., Skjerve, E., 2011. Q fever abortions in ruminants and associated on-farm risk factors in northern cyprus. BMC Veterinary Research 7, 13. [Crossref]
Cooper, A., Hedlefs, R., Ketheesan, N., Govan, B., 2011. Serological evidence of Coxiella burnetii infection in dogs in a regional centre: small animals. Australian Veterinary Journal 89, 385-387. [Crossref]
Esmaeili, S., Mobarez, A.M., Khalili, M., Mostafavi, E., 2019a. High prevalence and risk factors of Coxiella burnetii in milk of dairy animals with a history of abortion in iran. Comparative Immunology, Microbiology and Infectious Diseases 63, 127–130. [Crossref]
Esmaeili, S., Mobarez, A.M., Khalili, M., Mostafavi, E., Moradnejad, P., 2019b. Genetic evidence of Coxiella burnetii infection in acute febrile illnesses in Iran. PLoS Neglected Tropical Diseases 13, e0007181. [Crossref]
Ezatkhah, M., Alimolaei, M., Khalili, M., Sharifi, H., 2015. Seroepidemiological study of Q - fever in small ruminants from Southeast Iran. Journal of Infection and Public Health 8, 170–176. [Crossref]
Fujishiro, M.A., Scorza, A.V., Gookin, J.L., Lappin, M.R., 2016. Evaluation of associations among Coxiella burnetii and reproductive abnormalities in cats. Journal of Feline Medicine and Surgery 18, 344-347. [Crossref]
Greene, C.E., 2012. Q Fever. In: Greene, C.E. (Ed.), Infectious Diseases of the Dogs and Cats. 4th ed. Vol. 2. Elsevier Saunders, St Louis, pp. 482–484.
Gwida, M., 2012. Q fever: a re-emerging disease? Journal of Veterinary Science and Technology 03. [Crossref]
Havas, K.A., Burkman, K., 2011. A comparison of the serological evidence of Coxiella burnetii exposure between military working dogs and feral canines in Iraq. Military Medicine 176, 1101- 1103. [Crossref]
Higgins, D., Marrie, T.J., 1990. Seroepidemiology of Q fever among cats in New Brunswick and Prince Edward Island. Annals of the New York Academy of Sciences 590, 271-274. [Crossref]
Hornok, S., Dénes, B., Meli, M.L., Tánczos, B., Fekete, L., Gyuranecz, M., de la Fuente, J., Mera, I.G.F.d., Farkas, R., Hofmann-Lehmann, R., 2013. Non-pet dogs as sentinels and potential synanthropic reservoirs of tick-borne and zoonotic bacteria. Veterinary Microbiology 167, 700-703. [Crossref]
Kilic, S., Komiya, T., Celebi, B., Aydın, N., Saito, J., Toriniwa, H., Karatepe, B., Babur, C., 2008. Seroprevalence of Coxiella burnetii in stray cats in central anatolia. Turkish Journal of Veterinary and Animal Sciences 32, 483-486.
Knobel, D.L., Maina, A.N., Cutler, S.J., Ogola, E., Feikin, D.R., Junghae, M., Halliday, J.E.B., Richards, A.L., Breiman, R.F., Cleaveland, S., Njenga, M.K., 2013. Coxiella burnetii in humans, domestic ruminants, and ticks in rural western Kenya. The American Journal of Tropical Medicine and Hygiene 88, 513-518. [Crossref]
Komiya, T., Sadamasu, K., Kang, M.I., Tsuboshima, S., Fukushi, H., Hirai, K., 2003. Seroprevalence of Coxiella burnetii infections among cats in different living environments. Journal of Veterinary Medical Science 65, 1047-1048. [Crossref]
Kopecny, L., Bosward, K.L., Shapiro, A., Norris, J.M., 2013. Investigating Coxiella burnetii infection in a breeding cattery at the centre of a Q fever outbreak. Journal of Feline Medicine and Surgery 15, 1037-1045. [Crossref]
Kosatsky, T., 1984. Household outbreak of Q-fever pneumonia related to a parturient cat. The Lancet 324, 1447-1449. [Crossref]
Langley, J.M., Marrie, T.J., Covert, A., Waag, D.M., Williams, J.C., 1983. Poker players’ pneumonia. An urban outbreak of Q fever following exposure to a parturient cat. The New England Journal of Medicine 319, 354-356. [Crossref]
Marrie, T.J., Durant, H., Williams, J.C., Mintz, E., Waag, D.M., 1988a. Exposure to parturient cats: a risk factor for acquisition of Q fever in Maritime Canada. Journal of Infectious Diseases 158, 101-108. [Crossref]
Marrie, T.J., Langille, D., Papukna, V., Yates, L., 1989. Truckin’ pneumonia- an outbreak of Q fever in a truck repair plant probably due to aerosols from clothing contaminated by contact with newborn kittens. Epidemiology and Infection 102, 119-127. [Crossref]
Marrie, T.J., MacDonald, A., Durant, H., Yates, L., McCormick, L., 1988b. An outbreak of Q fever probably due to contact with a parturient cat. Chest 93, 98-103. [Crossref]
Matthewman, L., Kelly, P., Hayter, D., Downie, S., Wray, K., Bryson, N., Rycroft, A., Raoult, D., 1997. Exposure of cats in southern africa to Coxiella burnetii, the agent of Q fever. European Journal of Epidemiology 13, 477-479. [Crossref]
Maurin, M., Raoult, D.F., 1999. Q fever. Clinical Microbiology Reviews 12, 518-553. [Crossref]
Maywood, P., Boyd, R., 2011. Q fever in a small animal hospital. Australian College of Veterinary Scientists College Science Week Scientific Meeting. p. 4.
Mediannikov, O., Fenollar, F., Socolovschi, C., Diatta, G., Bassene, H., Molez, J.F., Sokhna, C., Trape, J.F., Raoult, D., 2010. Coxiella burnetii in humans and ticks in rural senegal. PLoS Neglected Tropical Diseases 4. [Crossref]
Nagaoka, H., Sugieda, M., Akiyama, M., Nishina, T., Akahane, S., Fujiwara, K., 1998. Isolation of Coxiella burnetii from the vagina of feline clients at veterinary clinics. Journal of Veterinary Medical Science 60, 251-252. [Crossref]
Nokhodian, Z., Feizi, A., Khalili, M., Ataei, B., Moradi, A., 2018. Molecular evidence and risk factors of Coxiella burnetii among seropositive high-risk individuals in the center of Iran. Comparative Immunology, Microbiology and Infectious Diseases 61, 34-37. [Crossref]
Norris, J.M., Bosward, K.L., Heller, J., 2013. Q fever: pets, vets and validating tests. Microbiology Australia 34, 186-188. [Crossref]
Parisi, A., Fraccalvieri, R., Cafiero, M., Miccolupo, A., Padalino, I., Montagna, C., Capuano, F., Sottili, R., 2006. Diagnosis of Coxiella burnetii- related abortion in Italian domestic ruminants using single-tube nested PCR. Veterinary Microbiology 118, 101-106. [Crossref]
Porter, S.R., Czaplicki, G., Mainil, J., Guattéo, R., Saegerman, C., 2011. Q fever: current state of knowledge and perspectives of research of a neglected zoonosis. International Journal of Microbiology 2011, 1-22. [Crossref]
Roest, H.I.J., van Solt, C.B., Tilburg, J.J.H.C., Klaassen, C.H.W., Hovius, E.K., Roest, F.T.F., Vellema, P., van den Brom, R., van Zijderveld, F.G., 2013. Search for possible additional reservoirs for human Q fever, the Netherlands. Emerging Infectious Diseases 19. [Crossref]
Skerget, M., Wenisch, C., Daxboeck, F., Krause, R., Haberl, R., Stuenzner, D., 2003. Cat or dog ownership and seroprevalence of ehrlichiosis, Q fever, and cat-scratch disease. Emerging Infectious Diseases 9, 1337-1340. [Crossref]
Willeberg, P., Ruppanner, R., Behymer, D.E., Haghighi, S., Kaneko, J.J., Franti, C.E., 1980. Environmental exposure to Coxiella burnetii: a sero-epidemiologic survey among domestic animals. American Journal of Epidemiology 111, 437-443. [Crossref]

APA	Rezaei M, KHALILI M, Saberi M, Nakhaei A, Bakhshaee Shahrbabaki F, abdoli nasab s, Otranto D, Corrente M (2021). Are Dogs and Cats Possible Reservoirs for Human Q Fever in Iran?. , 37 - 43. 10.5152/actavet.2020.20022
Chicago	Rezaei Mahdieh,KHALILI Mohammad,Saberi Mehdi,Nakhaei Alireza,Bakhshaee Shahrbabaki Farnoush,abdoli nasab shamim,Otranto Domenico,Corrente Marialaura Are Dogs and Cats Possible Reservoirs for Human Q Fever in Iran?. (2021): 37 - 43. 10.5152/actavet.2020.20022
MLA	Rezaei Mahdieh,KHALILI Mohammad,Saberi Mehdi,Nakhaei Alireza,Bakhshaee Shahrbabaki Farnoush,abdoli nasab shamim,Otranto Domenico,Corrente Marialaura Are Dogs and Cats Possible Reservoirs for Human Q Fever in Iran?. , 2021, ss.37 - 43. 10.5152/actavet.2020.20022
AMA	Rezaei M,KHALILI M,Saberi M,Nakhaei A,Bakhshaee Shahrbabaki F,abdoli nasab s,Otranto D,Corrente M Are Dogs and Cats Possible Reservoirs for Human Q Fever in Iran?. . 2021; 37 - 43. 10.5152/actavet.2020.20022
Vancouver	Rezaei M,KHALILI M,Saberi M,Nakhaei A,Bakhshaee Shahrbabaki F,abdoli nasab s,Otranto D,Corrente M Are Dogs and Cats Possible Reservoirs for Human Q Fever in Iran?. . 2021; 37 - 43. 10.5152/actavet.2020.20022
IEEE	Rezaei M,KHALILI M,Saberi M,Nakhaei A,Bakhshaee Shahrbabaki F,abdoli nasab s,Otranto D,Corrente M "Are Dogs and Cats Possible Reservoirs for Human Q Fever in Iran?." , ss.37 - 43, 2021. 10.5152/actavet.2020.20022
ISNAD	Rezaei, Mahdieh vd. "Are Dogs and Cats Possible Reservoirs for Human Q Fever in Iran?". (2021), 37-43. https://doi.org/10.5152/actavet.2020.20022

APA	Rezaei M, KHALILI M, Saberi M, Nakhaei A, Bakhshaee Shahrbabaki F, abdoli nasab s, Otranto D, Corrente M (2021). Are Dogs and Cats Possible Reservoirs for Human Q Fever in Iran?. Acta Veterinaria Eurasia, 47(1), 37 - 43. 10.5152/actavet.2020.20022
Chicago	Rezaei Mahdieh,KHALILI Mohammad,Saberi Mehdi,Nakhaei Alireza,Bakhshaee Shahrbabaki Farnoush,abdoli nasab shamim,Otranto Domenico,Corrente Marialaura Are Dogs and Cats Possible Reservoirs for Human Q Fever in Iran?. Acta Veterinaria Eurasia 47, no.1 (2021): 37 - 43. 10.5152/actavet.2020.20022
MLA	Rezaei Mahdieh,KHALILI Mohammad,Saberi Mehdi,Nakhaei Alireza,Bakhshaee Shahrbabaki Farnoush,abdoli nasab shamim,Otranto Domenico,Corrente Marialaura Are Dogs and Cats Possible Reservoirs for Human Q Fever in Iran?. Acta Veterinaria Eurasia, vol.47, no.1, 2021, ss.37 - 43. 10.5152/actavet.2020.20022
AMA	Rezaei M,KHALILI M,Saberi M,Nakhaei A,Bakhshaee Shahrbabaki F,abdoli nasab s,Otranto D,Corrente M Are Dogs and Cats Possible Reservoirs for Human Q Fever in Iran?. Acta Veterinaria Eurasia. 2021; 47(1): 37 - 43. 10.5152/actavet.2020.20022
Vancouver	Rezaei M,KHALILI M,Saberi M,Nakhaei A,Bakhshaee Shahrbabaki F,abdoli nasab s,Otranto D,Corrente M Are Dogs and Cats Possible Reservoirs for Human Q Fever in Iran?. Acta Veterinaria Eurasia. 2021; 47(1): 37 - 43. 10.5152/actavet.2020.20022
IEEE	Rezaei M,KHALILI M,Saberi M,Nakhaei A,Bakhshaee Shahrbabaki F,abdoli nasab s,Otranto D,Corrente M "Are Dogs and Cats Possible Reservoirs for Human Q Fever in Iran?." Acta Veterinaria Eurasia, 47, ss.37 - 43, 2021. 10.5152/actavet.2020.20022
ISNAD	Rezaei, Mahdieh vd. "Are Dogs and Cats Possible Reservoirs for Human Q Fever in Iran?". Acta Veterinaria Eurasia 47/1 (2021), 37-43. https://doi.org/10.5152/actavet.2020.20022