Acute compartment syndrome (ACS) is a painful condition dis rupting local circulation due to increased interstitial pressure. Altho ugh the most common cause is fractures, vascular injuries withoutfractures, arterial injuries after interventional procedures, rhabdom yolysis, drunkenness, and coma may also result in ACS. Here we reporta case of 21 year-old young woman with bilateral peripheral upper ext remity dysfunction after suicidal drug intoxication. She suffered fromacute renal failure, rhabdomyolysis and hemolytic anemia. During hos pitalisation and dialysis, compartment syndrome and peripheral nerveinjury showed up too. After recovering from the life threatening com plications, the patient continued her treatment with the physical the rapy and rehabilitation program for upper extremity peripheral nerveproblems. Unfortunately during this phase she was complicated withcomplex regional pain syndrome. After a 9 month period of medicaland physical therapy, she has a nearly fully functioning right hand butstiffness and atrophy of the left hand still causes disability.