Local steroid injections administered to reduce pain andsuppress inflammation due to musculoskeletal diseases are an impor tant component of conservative treatment but may cause side effectssuch as exacerbation of pain, soft tissue ecchymosis/calcification/at rophy, decrease/increase in skin pigmentation. Here, we aimed to pre sent a 53-year-old woman who developed steroid atrophy and skinhypopigmentation, followed by steroid injections for the treatment ofmedial epicondylitis. Steroid injections were applied at the 6th, 12th,and 24th months for the complaint of pain at the right elbow, which hasbeen going on for about 3 years. After the last injection, atrophy andhypopigmentation occurred around the medial epicondyle. Whenplanning local steroid injections, possible side effects should be con sidered and the duration of the preparation, solubility, applicationtechnique, and, if necessary, its repetition should be optimally regu lated.