Antibiotic Susceptibilities of Escherichia coli Strains Isolated From Urine Samples in a Tertiary Hospital in Eastern Turkey
Yıl: 2021 Cilt: 13 Sayı: 1 Sayfa Aralığı: 141 - 148 Metin Dili: İngilizce DOI: 10.18521/ktd.842668 İndeks Tarihi: 27-06-2021
Antibiotic Susceptibilities of Escherichia coli Strains Isolated From Urine Samples in a Tertiary Hospital in Eastern Turkey
Öz: Objective: Escherichia coli is the most common cause of urinary tract infections. The increase and spread of resistance to antibiotics is a serious problem in our country as well as in the world. The aim of this study was to determine the antimicrobial susceptibility profiles of E. coli strains that cause urinary tract infection.Methods: The antibiotic susceptibilities of 1850 E. coli strains isolated from urine samples of patients who applied to Urology service and outpatient clinics of Malatya Education and Research Hospital, which is a tertiary care hospital in eastern part of Turkey, over the 3 years between July 2016 and July 2019, were evaluated retrospectively from computer records using the Vitek 2.0 Compact automated system (BioMérieux, France). Antibiogram results were classified as susceptible, moderately susceptible and resistant.Result: Of the total 1850 samples, 1300 (70.3%) were female and 550 (29.7%) were male, with a mean age of 52 (18-104) years. 73 (3.9%) of the patients were inpatients and 1777 were outpatients. All the isolated E. coli strains were found to be susceptible to ampicillin 39.2%, amoxicillin-clavulanic acid 67.9%, piperacillin-tazobactam 80.8%, cefuroxime 67.1%, cefotaxime 68.8%, cefixime 67.7%, ceftazidime 71.2%, cefepime 73.9%, ertapeneme 97.9%, imipeneme 99.5%, meropeneme 99.7%, amikacin 89.7%, gentamicin 78.4%, norfloxacine 65.8%, ciprofloxacine 65.9%, nitrofurantoin 94.2% and fosfomycin 96.5%. Resistance rates were higher in inpatients as compared to outpatients. Antibiotic susceptibilities were found to be decreased in different age ranges with increasing age. Conclusion: When selecting the antimicrobial treatment in community-acquired urinary tract infections, considering the antimicrobial resistance data in the region, the choice of cost-effectivetreatment with high patient compliance and low resistance rates will increase treatment success. It is thought that antibiotic treatment should be determined according to the results of culture antibiograms, especially in nosocomial infections due to high resistance rates.
Anahtar Kelime: Türkiye'nin Doğusunda Üçüncü Basamak Bir Hastanede İdrar Örneklerinden İzole Edilen Escherichia coli Suşlarının Antibiyotiklere Duyarlılıkları
Öz: Amaç: Üriner sistem enfeksiyonlarının etkenleri arasında en sık Escherichia coli izoleedilmektedir. Antibiyotiklere karşı gelişen direncin artması ve yayılması bütün dünyada olduğu gibiülkemizde de ciddi bir sorundur. Çalışmamızda, üriner sistem enfeksiyonu etkeni olan E. coli suşlarının antimikrobiyal duyarlılık profillerinin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Temmuz 2016–Temmuz 2019 tarihleri arasında 3 yıllık süreçte, MalatyaEğitim ve Araştırma Hastanesi Üroloji servis ve polikliniklerine başvuran hastaların, idrarörneklerinden izole edilen 1850 Escherichia coli suşunun, Vitek 2.0 Compact otomatize sistemi(BioMérieux, Fransa) kullanılarak belirlenen antibiyotik duyarlılıkları bilgisayar kayıtları üzerindenretrospektif olarak incelenmiştir. Antibiyogram sonuçları duyarlı, orta duyarlı ve dirençli olaraksınıflandırılmıştır. Verilerin değerlendirilmesi aşamasında orta duyarlı suşlar dirençli olarak kabuledilmiştir.Bulgular: Toplam 1850 örneğin 1300'ü (%70,3) kadın, 550’si (%29,7) erkek hastaya ait olup tümhastaların yaş ortalaması 52 (18-104) idi. Hastaların 73'ü (%3,9) yatan hasta, 1777'si poliklinikhastasıydı. İzole edilen tüm Escherichia coli suşlarının ampisiline %39,2, amoksisilin-klavulonikasite %67,9, piperasilin-tazobaktama %80,8, sefuroksime %67,1, sefotaksime %68,8, sefiksime%67,7, seftazidime %71,2, sefepime %73,9, ertapeneme %97,9, imipeneme %99,5, meropeneme%99,7, amikasine %89,7, gentamisine %78,4, norfloksasine %65,8, siprofloksasine %65,9,nitrofurantoine %94,2 ve fosfomisine %96,5 duyarlı olduğu saptanmıştır. Yatan hastalarda dirençoranları ayaktan tedavi olanlara kıyasla yüksek bulunmuştur. Değişen yaş aralıklarında yaşilerledikçe antibiyotik duyarlılıklarının düştüğü görülmüştür. Sonuç: Toplum kökenli üriner sistem enfeksiyonlarında antimikrobiyal tedavi seçiminde, bölgeselantimikrobiyal direnç verileri göz önüne alınarak; direnç oranlarının düşük, hasta uyumununyüksek olduğu, maliyet etkin tedavilerin tercihi tedavi başarısını artıracaktır. Özellikle nozokomiyalenfeksiyonlarda yüksek direnç oranları nedeni ile kültür antibiyogram sonucuna göre antibiyotiktedavisinin belirlenmesi gerektiği düşünülmektedir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | ERDOĞAN E, AKBULUT M (2021). Antibiotic Susceptibilities of Escherichia coli Strains Isolated From Urine Samples in a Tertiary Hospital in Eastern Turkey. , 141 - 148. 10.18521/ktd.842668 |
| Chicago | ERDOĞAN Esra,AKBULUT Mehmet Levent Antibiotic Susceptibilities of Escherichia coli Strains Isolated From Urine Samples in a Tertiary Hospital in Eastern Turkey. (2021): 141 - 148. 10.18521/ktd.842668 |
| MLA | ERDOĞAN Esra,AKBULUT Mehmet Levent Antibiotic Susceptibilities of Escherichia coli Strains Isolated From Urine Samples in a Tertiary Hospital in Eastern Turkey. , 2021, ss.141 - 148. 10.18521/ktd.842668 |
| AMA | ERDOĞAN E,AKBULUT M Antibiotic Susceptibilities of Escherichia coli Strains Isolated From Urine Samples in a Tertiary Hospital in Eastern Turkey. . 2021; 141 - 148. 10.18521/ktd.842668 |
| Vancouver | ERDOĞAN E,AKBULUT M Antibiotic Susceptibilities of Escherichia coli Strains Isolated From Urine Samples in a Tertiary Hospital in Eastern Turkey. . 2021; 141 - 148. 10.18521/ktd.842668 |
| IEEE | ERDOĞAN E,AKBULUT M "Antibiotic Susceptibilities of Escherichia coli Strains Isolated From Urine Samples in a Tertiary Hospital in Eastern Turkey." , ss.141 - 148, 2021. 10.18521/ktd.842668 |
| ISNAD | ERDOĞAN, Esra - AKBULUT, Mehmet Levent. "Antibiotic Susceptibilities of Escherichia coli Strains Isolated From Urine Samples in a Tertiary Hospital in Eastern Turkey". (2021), 141-148. https://doi.org/10.18521/ktd.842668 |
| APA | ERDOĞAN E, AKBULUT M (2021). Antibiotic Susceptibilities of Escherichia coli Strains Isolated From Urine Samples in a Tertiary Hospital in Eastern Turkey. KONURALP TIP DERGİSİ, 13(1), 141 - 148. 10.18521/ktd.842668 |
| Chicago | ERDOĞAN Esra,AKBULUT Mehmet Levent Antibiotic Susceptibilities of Escherichia coli Strains Isolated From Urine Samples in a Tertiary Hospital in Eastern Turkey. KONURALP TIP DERGİSİ 13, no.1 (2021): 141 - 148. 10.18521/ktd.842668 |
| MLA | ERDOĞAN Esra,AKBULUT Mehmet Levent Antibiotic Susceptibilities of Escherichia coli Strains Isolated From Urine Samples in a Tertiary Hospital in Eastern Turkey. KONURALP TIP DERGİSİ, vol.13, no.1, 2021, ss.141 - 148. 10.18521/ktd.842668 |
| AMA | ERDOĞAN E,AKBULUT M Antibiotic Susceptibilities of Escherichia coli Strains Isolated From Urine Samples in a Tertiary Hospital in Eastern Turkey. KONURALP TIP DERGİSİ. 2021; 13(1): 141 - 148. 10.18521/ktd.842668 |
| Vancouver | ERDOĞAN E,AKBULUT M Antibiotic Susceptibilities of Escherichia coli Strains Isolated From Urine Samples in a Tertiary Hospital in Eastern Turkey. KONURALP TIP DERGİSİ. 2021; 13(1): 141 - 148. 10.18521/ktd.842668 |
| IEEE | ERDOĞAN E,AKBULUT M "Antibiotic Susceptibilities of Escherichia coli Strains Isolated From Urine Samples in a Tertiary Hospital in Eastern Turkey." KONURALP TIP DERGİSİ, 13, ss.141 - 148, 2021. 10.18521/ktd.842668 |
| ISNAD | ERDOĞAN, Esra - AKBULUT, Mehmet Levent. "Antibiotic Susceptibilities of Escherichia coli Strains Isolated From Urine Samples in a Tertiary Hospital in Eastern Turkey". KONURALP TIP DERGİSİ 13/1 (2021), 141-148. https://doi.org/10.18521/ktd.842668 |
