Mehmet COŞGUN
(Bolu Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Bolu, Türkiye)
Emrah ERDAL
(Bolu Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Bolu, Türkiye)
Yılmaz GÜNEŞ
(Bolu Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Bolu, Türkiye)
İsa SİNCER
(Bolu Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Bolu, Türkiye)
Aslı MANSIROĞLU
(Bolu Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Bolu, Türkiye)
Yıl: 2021Cilt: 4Sayı: 2ISSN: 2618-6454 / 2618-6454Sayfa Aralığı: 141 - 147İngilizce

69 0
Evaluation of electrocardiographic ventricular repolarization parameters in stable coronary artery disease
Aim: To examine the relationship between the SYNTAX score (SS) and cardiac repolarization parameterssuch as cQTd and Tp-e values, and Tp-e/QT, Tp-e/JT, Tp-e/QTc, and Tp-e/JTc ratios in patients who havestable angina pectoris.Methods: 12-lead resting electrocardiograms (ECGs) and SS of 160 patients (51 female and 109 male)undergoing coronary angiography with the pre-diagnosis of stable angina pectoris were evaluated. Patientswith a SS below 22 were classified as Group 1 (low-SYNTAX), and those above 22 (high-SYNTAX) as Group2. Forty-four patients with normal coronary angiography were included in Group 3.Results: Mean age of the patients was 62.4±9.1 years. The heart rate, QRS, QT, cQT and JT durations betweenthe groups were similar. In addition, relatively recent ventricular repolarization indices such as Tp-e intervaland Tp-e/QT, Tp-e/JT, Tp-e/QTc, and Tp-e/JTc ratios were also not substantially different between groups.Conclusion: Several surface ECG predictors of ventricular arrhythmias, including QTd, JT and Tp-e intervalsand their ratios to QT and JT, are not significantly correlated with SYNTAX score-assessed CAD severity inpatients with stable angina pectoris
DergiAraştırma MakalesiErişime Açık
  • [1]Nowbar AN, Gitto M, Howard JP, at al. Mortality From Ischemic Heart Disease. Circ Cardiovasc Qual Outcomes. 2019;12(6): e005375.
  • [2]Sara JD, Eleid MF, Gulati R, et al. Sudden Cardiac Death From the Perspective of Coronary Artery Disease. Mayo Clin Proc. 2014;89(12):1685-98.
  • [3]Priori SG, Blomström-Lundqvist C, Mazzanti A, et al. Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Europace. 2015;17(11):1601-87.
  • [4]Engel G, Beckerman JG, Froelicher VF, et al. Electrocardiographic arrhythmia risk testing. Curr Probl Cardiol. 2004;29(7):365- 32.
  • [5]Turakhia M, Tseng ZH. Sudden cardiac death: epidemiology, mechanisms, and therapy. Curr Probl Cardiol. 2007;32(9):501–46.
  • [6]Castro-Torres Y, Carmona-Puerta R, Katholi RE. Ventricular repolarization markers for predicting malignant arrhythmias in clinical practice. World J Clin Cases. 2015;3(8):705-20.
  • [7]Crow RS, Hannan PJ, Folsom AR. Prognostic significance of corrected QT and corrected JT interval for incident coronary heart disease in a general population sample stratified by presence or absence of wide QRS complex: the ARIC Study with 13 years of follow-up. Circulation. 2003;108(16):1985-89.
  • [8]Gupta P, Patel C, Patel H et al. T(p-e)/QT ratio as an index of arrhythmogenesis. J Electrocardiol. 2008;41(6):567–74.
  • [9]Castro-Torres Y. Tpeak-Tend/QT: un nuevo predictor electrocardiográfico de muerte súbita cardíaca. Cardiocore. 2014;49(2):86– 87.
  • [10]Sianos G, Morel MA, Kappetein AP, et al. The SYNTAX score: an angiographic tool grading the complexity of coronary artery disease. Euro Intervention. 2005;1(2):219– 27.
  • [11]Valgimigli M, Serruys PW, Tsuchida K, et al. Cyphering the complexity of coronary artery disease using the syntax score to predict clinical outcome in patients with three-vessel lumen obstruction undergoing percutaneous coronary intervention. Am J Cardiol. 2007;99(8):1072– 81.
  • [12]Lemesle G, Bonello L, de Labriolle A, et al. Prognostic value of the Syntax score in patients undergoing coronary artery bypass grafting for three-vessel coronary artery disease. Catheter Cardiovasc Interv. 2009;73(5):612–17.
  • [13]Capodanno D, Di Salvo ME, Cincotta G, et al. Usefulness of the SYNTAX score for predicting clinical outcome after percutaneous coronary intervention of unprotected left main coronary artery disease. Circ Cardiovasc Interv. 2009;2(4):302-8.
  • [14]Bazett HC. An analysis of the time relations of electrocardiograms. Heart. 1920;7:353- 70.
  • [15]Kolettis TM. In: Kibos A, Knight B, Essebag V, Fishberger S, Slevin M, Țintoiu I, editor. Ventricular Arrhythmias During Acute Myocardial Ischemia/Infarction: Mechanisms and Management. Cardiac Arrhythmias: Springer; 2014. p. 237-251.
  • [16]Di Diego JM, Antzelevitch C. Ischemic ventricular arrhythmias: Experimental models and their clinical relevance. Heart Rhythm. 2011;8(12):1963-68.
  • [17]Wei N, Tolkacheva EG. Interplay between ephaptic coupling and complex geometry of border zone during acute myocardial ischemia: Effect on arrhythmogeneity. Chaos: An Interdisciplinary Journal of Nonlinear Science. 2020;30(3):033111.
  • [18]Bernus O, Zemlin CW, Zaritsky RM, et al. Alternating conduction in the ischaemic border zone as precursor of reentrant arrhythmias: A simulation study. Europace. 2005;7(2):93-104.
  • [19]Wilde AA. Role of ATP-sensitive K+ channel current in ischemic arrhythmias. Cardiovasc Drugs Ther. 1993;7(3):521–26.
  • [20]Monitillo F, Leone M, Rizzo C, et al. Ventricular repolarization measures for arrhythmic risk stratification. World J Cardiol. 2016;8(1):57–73.
  • [21]Kautzner J. QT Interval Measurements. Card Electrophysiol Rev. 2002;6(3):273–77.
  • [22]Spodick DH. Reduction of QT-interval imprecision and variance by measuring the JT interval. Am J Cardiol. 1992;70(1):628– 29.
  • [23]Antzelevitch C. T peak-Tend interval as an index of transmural dispersion of repolarization. Eur J Clin Invest. 2001;31(7):555-57.
  • [24]Antzelevitch C. Heterogeneity and cardiac arrhythmias: an overview. Heart Rhythm. 2007;4(7):964-72.
  • [25]Yilmaz R, Demirbag R, Gur M. The association of QT dispersion and QT dispersion ratio with extent and severity of coronary artery disease. Ann Noninvasive Electrocardiol. 2006;11(1):43-51.
  • [26]Panikkath R, Reinier K, Uy-Evanado A, et al. Prolonged Tpeak-to-tend interval on the resting ECG is associated with increased risk of sudden cardiac death. Circ Arrhythm Electrophysiol. 2011;4(4):441-47.
  • [27]Chugh SS, Reinier K, Singh T, et al. Determinants of prolonged QT interval and their contribution to sudden death risk in coronary artery disease: the Oregon Sudden Unexpected Death Study. Circulation. 2009;119(5):663-70.
  • [28]Helmy H, Abdel-Galeel A, Kishk YT, et al. Correlation of corrected QT dispersion with the severity of coronary artery disease detected by SYNTAX score in non-diabetic patients with STEMI. Egypt Heart J. 2017;69(2):111-17.
  • [29]Bektaş O. The Association Between Coronary Artery Disease Severity And Tp-e İnterval, Tp-e/qt Ratio Parameters Including Fragmented Qrs. Am J Cardiol. 2018;121(8):e54.
  • [30]İpek E, Yolcu M, Yıldırım E, et al. The Relationship Between Electrocardiographic Tp-e Interval and Gensini & Syntax Scores in Patients with Stable Angina Pectoris. MN Kardiyoloji. 2016;23(3):126-31.

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