Evaluation of plasma GRP78 levels in patients withautism spectrum disorder
Yıl: 2021 Cilt: 34 Sayı: 1 Sayfa Aralığı: 83 - 88 Metin Dili: İngilizce DOI: 10.14744/DAJPNS.2020.00123 İndeks Tarihi: 18-06-2021
Evaluation of plasma GRP78 levels in patients withautism spectrum disorder
Öz: Objective: The role of endoplasmic reticulum (ER) stress in the pathogenesis of autism spectrum disorder (ASD) has been previously reported in both experimental and postmortem studies. However, no circulating marker of ER stress has been identified so far in ASD patients. In the present study, the plasma level of glucose-regulated protein 78 (GRP78) was investigated in ASD patients as a potential marker for ER stress.Method: Plasma samples taken from healthy control subjects (n=26) and ASD patients (n=29) were used to evaluate circulating GRP78 levels. Plasma GRP78 concentrations were measured by ELISA. The severity of the disease in the ASD group was determined by the childhood autism rating scale.Results: There was no significant difference between the median values of plasma GRP78 levels in ASD (12.40) and healthy control groups (11.11) (p<0.218). Plasma GRP78 concentration was 12.81±4.90 ng/mL in the ASD group and was not significantly different from the control values (11.12±3.83 ng/mL).Conclusion: Although ER stress was associated with ASD, our results showed that plasma levels of GRP78 did not change in ASD patients. Our results suggest that GRP78 is not an appropriate circulatory marker to evaluate ER stress in ASD patients.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Shore GC, Papa FR, Oakes SA. Signaling cell death from the endoplasmic reticulum stress response. Curr Opin Cell Biol 2011; 23:143-149.
- 2. Xu C, Bailly-Maitre B, Reed JC. Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 2005; 115:2656-2664.
- 3. Breckenridge DG, Germain M, Mathai JP, Nguyen M, Shore GC. Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene 2003; 22:8608-8618.
- 4. Hughes D, Mallucci GR. The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway. FEBS J 2019;286:342-355.
- 5. Yoshida H. ER stress and diseases. FEBS J 2007; 274:630-658. 6. Xiang C, Wang Y, Zhang H, Han F. The role of endoplasmic reticulum stress in neurodegenerative disease. Apoptosis 2017; 22:1-26.
- 7. García-González P, Cabral-Miranda F, Hetz C, Osorio F. Interplay between the unfolded protein response and ımmune function in the development of neurodegenerative diseases. Front Immunol 2018; 9:2541.
- 8. Muneer A, Shamsher Khan RM. Endoplasmic reticulum stress: implications for neuropsychiatric disorders. Chonnam Med J 2019; 55:8-19.
- 9. Patel S, Sharma D, Kalia K, Tiwari V. Crosstalk between endoplasmic reticulum stress and oxidative stress in schizophrenia: The dawn of new therapeutic approaches. Neurosci Biobehav Rev 2017; 83:589-603.
- 10. Bengesser SA, Reininghaus EZ, Dalkner N, Birner A, Hohenberger H, Queissner R, et al. Endoplasmic reticulum stress in bipolar disorder? - BiP and CHOP gene expression- and XBP1 splicing analysis in peripheral blood. Psychoneuroendocrinology 2018; 95:113-119.
- 11. Huang GH, Chen K, Sun YY, Zhu L, Sun ZL, Feng DF. 4-phenylbutyrate ameliorates anxiety disorder by ınhibiting endoplasmic reticulum stress after diffuse axonal ınjury. J Neurotrauma 2019; 36:1856-1868.
- 12. Wen L, Han F, Shi Y, Li X. Role of the endoplasmic reticulum pathway in the medial prefrontal cortex in post-traumatic stress disorder model rats. J Mol Neurosci 2016; 59:471-482.
- 13. Dong D, Zielke HR, Yeh D, Yang P. Cellular stress and apoptosis contribute to the pathogenesis of autism spectrum disorder. Autism Res 2018; 11:1076-1090.
- 14. Crider A, Ahmed AO, Pillai A. Altered expression of endoplasmic reticulum stress-related genes in the middle frontal cortex of subjects with autism spectrum disorder. Mol Neuropsychiatry 2017; 3:85-91.
- 15. Kawada K, Mimori S. Implication of endoplasmic reticulum stress in autism spectrum disorder. Neurochem Res 2018; 43:147-152.
- 16. Kawada K, Mimori S, Okuma Y, Nomura Y. Involvement of endoplasmic reticulum stress and neurite outgrowth in the model mice of autism spectrum disorder. Neurochem Int 2018; 119:115-119.
- 17. Lai MC, Lombardo MV, Baron-Cohen S. Autism. Lancet 2014; 383:896-910.
- 18. Chaste P, Leboyer M. Autism risk factors: genes, environment, and gene-environment interactions. Dialogues Clin Neurosci 2012; 14:281-292.
- 19. Tsai SA, Bendriem RM, Lee CD. The cellular basis of fetal endoplasmic reticulum stress and oxidative stress in drug-induced neurodevelopmental deficits. Neurobiol Stress 2018; 10:100145.
- 20. Khadir A, Kavalakatt S, Abubaker J, Cherian P, Madhu D, Al-Khairi I, et al. Physical exercise alleviates ER stress in obese humans through reduction in the expression and release of GRP78 chaperone. Metabolism 2016; 65:1409-1420.
- 21. Delpino A, Castelli M. The 78 kDa glucose-regulated protein (GRP78/BIP) is expressed on the cell membrane, is released into cell culture medium and is also present in human peripheral circulation. Biosci Rep 2002; 22:407-420.
- 22. Cirrik S, Cetinkol Y, Altuncekic Yildirim A, Calgin MK, NoyanT. Circulating glucose-regulated protein 78 levels in patients with chronic Hepatitis B infection. Viral Hepatitis Journal 2018; 24;85-89.
- 23. Fiorentino M, Sapone A, Senger S, Camhi SS, Kadzielski SM, Buie TM, et al. Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders. Mol Autism 2016; 7:49.
- 24. Kumar H, Sharma B. Minocycline ameliorates prenatal valproic acid induced autistic behaviour, biochemistry and blood brain barrier impairments in rats. Brain Res 2016; 1630:83-97.
- 25. Theoharides TC, Zhang B. Neuro-inflammation, blood-brain barrier, seizures and autism. J Neuroinflammation 2011; 8:168.
- 26. Sucuoglu B, Oktem F, Akkok F, Gokler B. A study of the scales for the assessment of the children with autism. Psikiyatri Psikoloji Psikofarmakoloji Dergisi 1996; 4,116-121. (Turkish)
- 27. Unal F, Oktem F, Cetin Cuhadaroglu F, Cengel Kultur SE, Akdemir D, Foto Ozdemir D, et al. Reliability and Validity of the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version, DSM-5 November 2016-Turkish Adaptation (K-SADS-PL-DSM-5-T). Turk Psikiyatri Derg 2019; 30:42-50 (Turkish).
- 28. Birmaher B, Ehmann M, Axelson DA, Goldstein BI, Monk K, Kalas C, et al. Schedule for affective disorders and schizophrenia for school-age children (K-SADS-PL) for the assessment of preschool children--a preliminary psychometric study. J Psychiatr Res 2009; 43:680-686.
- 29. Nicolini C, Fahnestock M. The valproic acid-induced rodent model of autism. Exp Neurol 2018; 299:217-227.
- 30. Lewis JD, Theilmann RJ, Townsend J, Evans AC. Network efficiency in autism spectrum disorder and its relation to brain overgrowth. Front Hum Neurosci 2013; 7:845.
- 31. Kawada K, Iekumo T, Saito R, Kaneko M, Mimori S, Nomura Y, et al. Aberrant neuronal differentiation and inhibition of dendrite outgrowth resulting from endoplasmic reticulum stress. J Neurosci Res 2014; 92:1122-1133.
- 32. Fujita E, Dai H, Tanabe Y, Zhiling Y, Yamagata T, Miyakawa T, et al. Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule, CADM1. Cell Death Dis 2010; 1:e47.
- 33. Momoi T, Fujita E, Senoo H, Momoi M. Genetic factors and epigenetic factors for autism: endoplasmic reticulum stress and impaired synaptic function. Cell Biol Int 2009; 34:13-19
| APA | cırrık s, Esnafoglu E, ADIGÜZEL AKMAN Ö (2021). Evaluation of plasma GRP78 levels in patients withautism spectrum disorder. , 83 - 88. 10.14744/DAJPNS.2020.00123 |
| Chicago | cırrık selma,Esnafoglu Erman,ADIGÜZEL AKMAN ÖZNUR Evaluation of plasma GRP78 levels in patients withautism spectrum disorder. (2021): 83 - 88. 10.14744/DAJPNS.2020.00123 |
| MLA | cırrık selma,Esnafoglu Erman,ADIGÜZEL AKMAN ÖZNUR Evaluation of plasma GRP78 levels in patients withautism spectrum disorder. , 2021, ss.83 - 88. 10.14744/DAJPNS.2020.00123 |
| AMA | cırrık s,Esnafoglu E,ADIGÜZEL AKMAN Ö Evaluation of plasma GRP78 levels in patients withautism spectrum disorder. . 2021; 83 - 88. 10.14744/DAJPNS.2020.00123 |
| Vancouver | cırrık s,Esnafoglu E,ADIGÜZEL AKMAN Ö Evaluation of plasma GRP78 levels in patients withautism spectrum disorder. . 2021; 83 - 88. 10.14744/DAJPNS.2020.00123 |
| IEEE | cırrık s,Esnafoglu E,ADIGÜZEL AKMAN Ö "Evaluation of plasma GRP78 levels in patients withautism spectrum disorder." , ss.83 - 88, 2021. 10.14744/DAJPNS.2020.00123 |
| ISNAD | cırrık, selma vd. "Evaluation of plasma GRP78 levels in patients withautism spectrum disorder". (2021), 83-88. https://doi.org/10.14744/DAJPNS.2020.00123 |
| APA | cırrık s, Esnafoglu E, ADIGÜZEL AKMAN Ö (2021). Evaluation of plasma GRP78 levels in patients withautism spectrum disorder. Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi, 34(1), 83 - 88. 10.14744/DAJPNS.2020.00123 |
| Chicago | cırrık selma,Esnafoglu Erman,ADIGÜZEL AKMAN ÖZNUR Evaluation of plasma GRP78 levels in patients withautism spectrum disorder. Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi 34, no.1 (2021): 83 - 88. 10.14744/DAJPNS.2020.00123 |
| MLA | cırrık selma,Esnafoglu Erman,ADIGÜZEL AKMAN ÖZNUR Evaluation of plasma GRP78 levels in patients withautism spectrum disorder. Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi, vol.34, no.1, 2021, ss.83 - 88. 10.14744/DAJPNS.2020.00123 |
| AMA | cırrık s,Esnafoglu E,ADIGÜZEL AKMAN Ö Evaluation of plasma GRP78 levels in patients withautism spectrum disorder. Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi. 2021; 34(1): 83 - 88. 10.14744/DAJPNS.2020.00123 |
| Vancouver | cırrık s,Esnafoglu E,ADIGÜZEL AKMAN Ö Evaluation of plasma GRP78 levels in patients withautism spectrum disorder. Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi. 2021; 34(1): 83 - 88. 10.14744/DAJPNS.2020.00123 |
| IEEE | cırrık s,Esnafoglu E,ADIGÜZEL AKMAN Ö "Evaluation of plasma GRP78 levels in patients withautism spectrum disorder." Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi, 34, ss.83 - 88, 2021. 10.14744/DAJPNS.2020.00123 |
| ISNAD | cırrık, selma vd. "Evaluation of plasma GRP78 levels in patients withautism spectrum disorder". Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi 34/1 (2021), 83-88. https://doi.org/10.14744/DAJPNS.2020.00123 |
