Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?

TOGRUL, cihan; ARSLAN, EMINE; GORKEM, Umit

Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?

Emine ARSLAN, (Hitit Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı Jinekoloji, Çorum, Türkiye)

Ümit GÖRKEM, (Hitit Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı Jinekoloji, Çorum, Türkiye)

Cihan TOGRUL (Hitit Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı Jinekoloji, Çorum, Türkiye)

GORM:Gynecology Obstetrics & Reproductive Medicine

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Yıl: 2020 Cilt: 26 Sayı: 3 Sayfa Aralığı: 179 - 183 Metin Dili: İngilizce İndeks Tarihi: 19-06-2021

Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?

Öz:

OBJECTIVE: To find out the relationship of maternal serum levels of kisspeptin with gestational diabetes mellitus status.STUDY DESIGN: A total of 158 pregnant women between 24 and 28 weeks of gestation were divided into two groups according to gestational diabetes mellitus status: (i) Pregnant women with gestational diabetes mellitus (gestational diabetes mellitus group, n=76) and (ii) Healthy pregnant women (control group, n=82). Maternal serum concentrations of kisspeptin, insulin, and homeostasis model assessment- insulin resistance were assessed.RESULTS: In both groups, there were no difference in terms of age and gestational age (p=0.058 and p=0.820, respectively). The median of body mass indices of both groups at 24 to 28 weeks of gestation were statistically similar (p=0.062). The serum concentrations of kisspeptin did not demonstrate significant differences between the gestational diabetes mellitus and control groups (p=0.28). There was a significant difference in terms of serum level of insulin and homeostasis model assessment-insulin resistance between the gestational diabetes mellitus and control groups (p<0.001).CONCLUSION: No differences were found in serum kisspeptin levels between pregnant women with GDM and healthy pregnant women. Further prospective studies will be essential to elucidate the contribution of kisspeptin to gestational diabetes mellitus.

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1. Lee JH, Miele ME, Hicks DJ, Phillips KK, Trent JM, Weissman BE, et al. KiSS-1, a novel human malignant melanoma metastasis suppressor gene. J Natl Cancer Inst. 1996;88(23):1731-7. doi: 10.1093/jnci/88.23.1731
2. Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno JS Jr, Shagoury JK, et al. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003;349(17):1614- 27. doi: 10.1056 / NEJMoa035322.
3. Bilban M, Ghaffari-Tabrizi N, Hintermann E, Bauer S, Molzer S, Zoratti C, et al. isspeptin-10, a KiSS-1/ metas - tin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts. J Cell Sci. 2004;117(Pt 8):1319-28. doi: 10.1242/jcs.00971
4. Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, et al. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem. 2001;276(37):34631-6. doi: 10.1074/jbc. M104847200.
5. Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, et al. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein coupled receptor. Nature. 2001;411(6837):613-7. doi: 10.1038/35079135.
6. Horikoshi Y, Matsumoto H, Takatsu Y, Ohtaki T, Kitada C, Usuki S, et al. Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta- derived hormone in humans. J Clin Endocrinol Metab. 2003;88(2):914-9. doi: 10.1210/jc.2002-021235
7. Janneau JL, Maldonado-Estrada J, Tachdjian G, Miran I, Motte N, Saulnier P, et al. Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. J Clin Endocrinol Metab. 2002;87(11):5336-9. doi: 10.1210/jc.2002-021093.
8. Hiden U, Bilban M, Knofler M, Desoye G. Kisspeptins and the placenta: regulation of trophoblast invasion. Rev Endocr Metab Disord. 2007;8(1):31-9. doi: 10.1007/ s11154-007-9030-8.
9. Smets E, Deurloo KL, Go AT, van Vugt JM, Blankenstein MA, Oudejans CB. Decreased plasma levels of metastin in early pregnancy are associated with small for gestational age neonates. Prenat Diagn. 2008;28(4):299-303. doi: 10.1002/pd.1969.
10. Armstrong RA, Reynolds RM, Leask R, Shearing CH, Calder AA, Riley SC. Decreased serum levels of kiss pep - tin in early pregnancy are associated with intrauterine growth restriction and pre-eclampsia. Prenat Diagn. 2009;29(10):982-5. doi: 10.1002/pd.2328
11. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin. No. 190: gestational diabetes mellitus. Obstet Gynecol. 2018;131(2):e49-e64.
12. Correa A, Bardenheier B, Elixhauser A, Geiss LS, Gregg E. Trends in prevalence of diabetes among delivery hospitalizations, United States, 1993-2009. Matern Child Health J. 2015;19(3):635-42. doi: 10.1007/s10995-014- 1553-5.
13. Aydın H, Celik O, Yazıcı D, Altunok C, Tarcın O, Deyneli O, et al. Prevalence and predictors of gestational diabetes mellitus: a nationwide multicentre prospective study. Diabet Med. 2019;36(2):221-7. doi: 10.1111/dme.13857.
14. Ozgu-Erdinc AS, Sert UY, Buyuk GN, Engin-Ustun Y.Prevalence of gestational diabetes mellitus and results of the screening tests at a tertiary referral center: A crosssectional study. Diabetes Metab Syndr. 2019;13(1):74-7. DOI: 10.1016/j.dsx.2018.08.019
15. Ayhan S, Altinkaya SO, Gungor T, Ozcan U. Prognosis of pregnancies with different degrees of glucose intolerance. Gynecol Obstet Reprod Med. 2016;19(2):76-81.
16. Smith JT, Dungan HM, Stoll EA, Gottsch ML, Braun RE, Eacker SM, et al. Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse. Endocrinology. 2005;146(7):2976-84. doi: 10. 1210/en.2005-0323. Epub 2005 Apr 14.
17. Smith JT, Cunningham MJ, Rissman EF, Clifton DK, Steiner RA. Regulation of kiss1 gene expression in the brain of the female mouse. Endocrinology. 2005;146 (9):3686-92. doi: 10.1210/en.2005-0488.
18. Song WJ, Mondal P, Wolfe A, Alonso LC, Stamateris R, Ong BW, et al. Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab. 2014;19(4):667-81. doi: 10.1016/j.cmet.2014.03.005.
19. Tolson KP, Garcia C, Yen S, Simonds S, Stefanidis A, Lawrence A, et al. Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity. J Clin Invest. 2014;124(7):3075-9. doi: 10. 1172/ JCI71075.
20. Katugampola H, King PJ, Chatterjee S, Meso M, Duncan AJ, Achermann JC, et al. Kisspeptin is a novel regulator of human fetal adrenocortical development and function: a finding with important implications for the human fetoplacental unit. J Clin Endocrinol Metab. 2017;102(9): 3349-59. doi: 10.1210/jc.2017-00763.
21. Taylor J, Pampillo M, Bhattacharya M, Babwah AV. Kisspeptin/KISS1R signaling potentiates extravillous trophoblast adhesion to type-I collagen in a PKC- and ERK1/2-dependent manner. Mol Reprod Dev. 2014; 81(1):42-54. doi: 10.1002/mrd.22279.
22. Carpenter MW, Coustan DR. Criteria for screening tests for gestational diabetes. Am J Obstet Gynecol. 1982; 144(7):768-73. doi: 10.1016/0002-9378 (82) 90349-0.
23. Muller WA, Faloona GR, UngerRH. Hyperglucagonemia in diabetic ketoacidosis. Its prevalence and significance. Am J Med. 1973;54(1):52-7. doi: 10.1016/0002- 9343(73)90083-1.
24. Dumonteil E, Magnan C, Ritz-Laser B, Meda P, Dussoix P, Gilbert M, et al. Insulin, but not glucose lowering corrects the hyperglucagonemia and increased proglucagon messenger ribonucleic acid levels observed in insulinopenic diabetes. Endocrinology. 998;139(11):4540- 6. doi: 10.1210/endo.139.11.6294.
25. Kawamori D, Kurpad AJ, Hu J, Liew CW, Shih JL, Ford EL, et al. Insulin signaling in alpha cells modulates glucagon secretion in vivo. Cell Metab. 2009;9(4):350-61. doi: 10.1016/j.cmet.2009.02.007.
26. D’Alessio, D. The role of dysregulated glucagon secretion in type 2 diabetes. Diabetes Obes Metab. 2011;13(1):126- 32. doi: 10.1111/j.1463-1326.2011.01449.x.
27. Hussain MA, Song WJ, Wolfe A. There is kisspeptin – and then there is kisspeptin. Trends Endocrinol Metab.2015;26(10):564-72. doi: 10.1016/j.tem.2015.07.008.
28. Hauge-Evans AC, Richardson CC, Milne HM, ChristieMR, Persaud SJ, Jones PM. A role for kisspeptin in islet function. Diabetologia. 2006;49(9):2131-5. doi: 10.1007/s00125-006-0343-z.
29. Silvestre RA, Egido EM, Hernandez R, Marco J. Kisspeptin-13 inhibits insulin secretion without affecting glucagon or somatostatin release: study in the perfused rat pancreas. J Endocrinol. 2008;196(2):283-90. doi: 10. 1677/ JOE-07-0454.
30. Vikman J, Ahren B. Inhibitory effect of kisspeptins on insülin secretion from isolated Mouse islets. Diabetes Obes Metab. 2009;11(4):197-201. doi: 10.1111/j.1463-1326. 2009.01116.x.
31. Ryan EA. Hormones and insulin resistance during pregnancy. Lancet. 2003;362(9398):1777-8. doi: 10.1016/ S0140-6736(03)14942-2.
32. Cetković A, Miljic D, Ljubić A, Patterson M, Ghatei M, Stamenković J, et al. Plasma kisspeptin levels in pregnancies with diabetes and hypertensive disease as a potential marker of placental dysfunction and adverse perinatal outcome. Endocrine Research. 2012;37(2):78-88. doi: 10. 3109/07435800.2011.639319.

APA	ARSLAN E, GORKEM U, TOGRUL c (2020). Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?. , 179 - 183.
Chicago	ARSLAN EMINE,GORKEM Umit,TOGRUL cihan Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?. (2020): 179 - 183.
MLA	ARSLAN EMINE,GORKEM Umit,TOGRUL cihan Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?. , 2020, ss.179 - 183.
AMA	ARSLAN E,GORKEM U,TOGRUL c Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?. . 2020; 179 - 183.
Vancouver	ARSLAN E,GORKEM U,TOGRUL c Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?. . 2020; 179 - 183.
IEEE	ARSLAN E,GORKEM U,TOGRUL c "Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?." , ss.179 - 183, 2020.
ISNAD	ARSLAN, EMINE vd. "Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?". (2020), 179-183.

APA	ARSLAN E, GORKEM U, TOGRUL c (2020). Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?. GORM:Gynecology Obstetrics & Reproductive Medicine, 26(3), 179 - 183.
Chicago	ARSLAN EMINE,GORKEM Umit,TOGRUL cihan Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?. GORM:Gynecology Obstetrics & Reproductive Medicine 26, no.3 (2020): 179 - 183.
MLA	ARSLAN EMINE,GORKEM Umit,TOGRUL cihan Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?. GORM:Gynecology Obstetrics & Reproductive Medicine, vol.26, no.3, 2020, ss.179 - 183.
AMA	ARSLAN E,GORKEM U,TOGRUL c Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?. GORM:Gynecology Obstetrics & Reproductive Medicine. 2020; 26(3): 179 - 183.
Vancouver	ARSLAN E,GORKEM U,TOGRUL c Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?. GORM:Gynecology Obstetrics & Reproductive Medicine. 2020; 26(3): 179 - 183.
IEEE	ARSLAN E,GORKEM U,TOGRUL c "Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?." GORM:Gynecology Obstetrics & Reproductive Medicine, 26, ss.179 - 183, 2020.
ISNAD	ARSLAN, EMINE vd. "Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?". GORM:Gynecology Obstetrics & Reproductive Medicine 26/3 (2020), 179-183.