An overview of vitamin B12 and iron deficiencies as a risk factors in children with febrile seizure etiology

Sevim TÜRAY, (Düzce Üniversitesi, Tıp Fakültesi, Pediatrik Nöroloji Anabilim Dalı, Düzce, Türkiye)
Fatma HANCI, (Bolu Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, Çocuk Nöroloji Anabilim Dalı, Bolu, Türkiye)
Sukriye ÖZDE (Düzce Üniversitesi, Tıp Fakültesi, Pediatri Anabilim Dalı, Düzce, Türkiye)
Experimental Biomedical Research
16 0
Yıl: 2021 Cilt: 4 Sayı: 2 Sayfa Aralığı: 154 - 163 Metin Dili: İngilizce DOI: 10.30714/j-ebr.2021267979 İndeks Tarihi: 19-06-2021

An overview of vitamin B12 and iron deficiencies as a risk factors in children with febrile seizure etiology

Öz:
Aim: To determine serum iron, ferritin, folate, and vitamin B12 deficiency and associated hemoglobin (Hb),hematocrit (Hct), mean corpuscular volume (MCV), and red cell distribution width (RDW) values in childrenundergoing febrile seizure, and thus to reveal their potential etiological role.Method: The serum iron, folate, vitamin B12, and ferritin, and Hb, Hct, MCV, and RDW values of 98 patientsundergoing FS and presenting to the pediatric neurology department and of 64 control patients were retrievedretrospectively and compared. Patient group data were also compared within the group.Results: Serum iron, ferritin, and vitamin B12 values were significantly lower in the patient group than in thecontrol group. Intragroup comparison revealed higher RDW values in patients with more than three FS and inthose with complicated seizures.Conclusion: This is the first study to investigate the relationship between vitamin B12, folate, and irondeficiency and FS. It should be remembered that deficiencies in these micronutrients, which are not routinelyinvestigated in patients presenting with FS, may play a role in the etiology, and that the frequency can decreasewith treatment. It should also not be forgotten that FS patients with high RDW values may be at risk of frequentseizure recurrence.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • [1]Seinfeld S, Shinnar S. Febrile Seizures. In: Swaiman KF, Aswal S, Ferriero DM, eds. Swaiman’s Pediatric Neurology, Principles and Practice, 6th edn. Elsevier Saunders, UK/USA. 2017; pp 519-23.
  • [2]Berg AT. Febrile seizures and epilepsy: the contributions of epidemiology. Paediatr Perinat Epidemiol. 1992;6(2):145–52.
  • [3]Guidelines for Epidemiologic Studies on Epilepsy. Commission on epidemiology and prognosis, international league against epilepsy. Epilepsia. 1993;34(4): 592-96.
  • [4]Steering Committee on Quality Improvement and Management, Subcommittee on Febrile Seizures American Academy of Pediatrics. Febrile seizures: clinical practice guideline for the long-term management of the child with simple febrile seizures. Pediatrics. 2008;121(6):1281–86.
  • [5]Subcommittee on Febrile seizures, American Academy of Pediatrics. Neurodiagnostic evaluation of the child with a simple febrile seizure. Pediatrics. 2011;127(2):389–94.
  • [6]Nelson KB, Ellenberg JH. Predictors of epilepsy in children who have experienced febrile seizures. N Engl J Med. 1976; 295(19): 1029 –33.
  • [7]Paul SP, Rogers E, Wilkinson R, et al. Management of febrile convulsion in children. Emerg Nurse. 2015;23(2): 18–25.
  • [8]Rouault TA, Cooperman S. Brain iron metabolism. Semin Pediatr Neurol. 2006;13(3):142–48.
  • [9]Kwak BO, Kim K, Kim SN, et al. Relationship between iron deficiency anemia and febrile seizures in children: a systematic review and metaanalysis. Seizure. 2017; 52:27–34.
  • [10]Pisacane A, Sansone R, Impagliazzo N, et al. Iron deficiency anaemia and febrile convulsions: case-control study in children under 2 years. Br Med J. 1996;10;313(7053):343.
  • [11]Lozoff B, Georgieff MK. Iron deficiency and brain development. Semin Pediatr Neurol. 2006;13(3):158-65.
  • [12]Beard JL. Iron biology in immune function, muscle metabolism and neuronal functioning. J Nutr. 2001;131(2S-2):568-79.
  • [13]Serin HM, Arslan EA. Neurological symptoms of vitamin B12 deficiency: analysis of pediatric patients. Acta Clin Croat. 2019;58(2):295-302.
  • [14]Demir N, Koc A, Üstyol L, et al. Clinical and neurological findings of severe vitamin B12 deficiency in infancy and importance of early diagnosis and treatment. J Paediatr Child Health. 2013;49(10):820-24.
  • [15]Kumar S . Recurrent seizures: an unusual manifestation of vitamin B12 deficiency. Neurol India. 2004;52(1):122-23.
  • [16]Glaser K, Girschick HJ, Schropp C, et al. Psychomotor development following early treatment of severe infantile vitamin B12 deficiency and West syndrome--is everything fine? A case report and review of literature. Brain Dev. 2015; 37(3):347-51.
  • [17]Naha K, Dasari S, Vivek G, et al. Vitamin B₁₂ deficiency: an unusual cause for recurrent generalised seizures with pancytopaenia. BMJ Case Rep. 2012;3:2012:bcr2012006632.
  • [18] Ganesh R, Janakiraman L. Serum zinc levels in children with simple febrile seizure. Clin Pediatr (Phila). 2008;47(2):164–66.
  • [19]Sharawat IK, Singh J, Dawman L, et al. Evaluation of Risk Factors associated with First Episode Febrile Seizures. J Clin Diagn Res. 2016;10(5):SC10–13.
  • [20]Smith DK, Sadler KP, Benedum M. Febrile Seizures: Risks, Evaluation, and Prognosis. Am Fam Physician. 2019;99(7):445-50.
  • [21]Berg AT, Shinnar S, Hauser WA, et al. Predictors of recurrent febrile seizures: a metaanalytic review. J Pediatr 1990;116(3):329–37.
  • [22]Seinfeld S, Glauser TA, Shinnar S. Febrile Seizures. Pellock JM, Nordii DR, Sankar R, Wheless JW, eds. Pellock’s Pediatric Epilepsy, 4th edn, New York: Demos Medical Publishing. 2017: pp.505-16.
  • [23]Mikati MA, Tchapyjnikov D. Febrile Seizures. Kliegman RM, Geme J St, Nelson Textbook of Pediatrics 21st Ed, Elsevier. 2019; pp.3092-94.
  • [24]Aziz KT, Ahmed N, Nagi AG. Iron Deficiency Anaemia As Risk Factor For Simple Febrile Seizures: A Case Control Study. J Ayub Med Coll Abbottabad. 2017;29(2):316-19.
  • [25]Rudy M, Mayer-Proschel M. Iron Deficiency Affects Seizure Susceptibility in a Time and Sex Specific Manner. ASN Neuro. 2017;9(6):1759091417746521.
  • [26]Jang HN, Yoon HS, Lee E.H . Prospective case control study of iron deficiency and the risk of febrile seizures in children in South Korea. BMC Pediatr 2019;19(1): 309.
  • [27]Kobrinsky NL, Yager JY, Cheang MS, et al. Does iron deficiency raise the seizure threshold? J Child Neurol. 1995;10(2):105– 9.
  • [28]Soheilipoor F, Tavasoli A, Babasafari Renani Z. The Association between Failure to Thrive or Anemia and Febrile Seizures in Children between 6 Months to 6 Years Old Age. Iran J Child Neurol. 2018;12(3):86-93.
  • [29]Habibian N, Alipour A, Rezaianzadeh A. Association between Iron Deficiency Anemia and Febrile Convulsion in 3- to 60- Month-Old Children: A Systematic Review and Meta-Analysis. Iran J Med Sci. 2014;39(6):496-505.
  • [30]Miller A, Korem M, Almog R, et al. Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. J Neurol Sci. 2005;233(1-2):93-97.
  • [31]Froese DS, Fowler B, Baumgartner MR. Vitamin B12, folate, and the methionine remethylation cycle-biochemistry, pathways, and regulation. J Inherit Metab Dis. 2019;42(4):673-85.
  • [32]Rosenblatt DS, Aspler AL, Shevell MI, et al. Clinical heterogeneity and prognosis in combined methylmalonic aciduria and homocystinuria. J Inherit Metab Dis. 1997;20(4): 528-38.
  • [33]Dror DK, Allen LH. Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms, Nutrition Reviews. 2008;66(5),:250–55.
  • [34]Akaike A, Tamura Y, Sato Y, et al. Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons. Eur J Pharmacol. 1993; 241(1):1-6.
  • [35]Osifo BO, Lukanmbi FA, Familusi JB. Cerebrospinal fluid folate and cobalamin levels in febrile convulsion. J Neurol Sci. 1985;68(2-3):185-90.
  • [36]Özkale Y, Erol İ, Kılıçarslan B, et al. Serum vitamin B12, folic acid, and homocysteine levels in children with febrile seizure. Turk J Pediatr. 2015;57(4):345-52.
APA Türay S, hancı f, Ozde S (2021). An overview of vitamin B12 and iron deficiencies as a risk factors in children with febrile seizure etiology. , 154 - 163. 10.30714/j-ebr.2021267979
Chicago Türay Sevim,hancı fatma,Ozde Sukriye An overview of vitamin B12 and iron deficiencies as a risk factors in children with febrile seizure etiology. (2021): 154 - 163. 10.30714/j-ebr.2021267979
MLA Türay Sevim,hancı fatma,Ozde Sukriye An overview of vitamin B12 and iron deficiencies as a risk factors in children with febrile seizure etiology. , 2021, ss.154 - 163. 10.30714/j-ebr.2021267979
AMA Türay S,hancı f,Ozde S An overview of vitamin B12 and iron deficiencies as a risk factors in children with febrile seizure etiology. . 2021; 154 - 163. 10.30714/j-ebr.2021267979
Vancouver Türay S,hancı f,Ozde S An overview of vitamin B12 and iron deficiencies as a risk factors in children with febrile seizure etiology. . 2021; 154 - 163. 10.30714/j-ebr.2021267979
IEEE Türay S,hancı f,Ozde S "An overview of vitamin B12 and iron deficiencies as a risk factors in children with febrile seizure etiology." , ss.154 - 163, 2021. 10.30714/j-ebr.2021267979
ISNAD Türay, Sevim vd. "An overview of vitamin B12 and iron deficiencies as a risk factors in children with febrile seizure etiology". (2021), 154-163. https://doi.org/10.30714/j-ebr.2021267979
APA Türay S, hancı f, Ozde S (2021). An overview of vitamin B12 and iron deficiencies as a risk factors in children with febrile seizure etiology. Experimental Biomedical Research, 4(2), 154 - 163. 10.30714/j-ebr.2021267979
Chicago Türay Sevim,hancı fatma,Ozde Sukriye An overview of vitamin B12 and iron deficiencies as a risk factors in children with febrile seizure etiology. Experimental Biomedical Research 4, no.2 (2021): 154 - 163. 10.30714/j-ebr.2021267979
MLA Türay Sevim,hancı fatma,Ozde Sukriye An overview of vitamin B12 and iron deficiencies as a risk factors in children with febrile seizure etiology. Experimental Biomedical Research, vol.4, no.2, 2021, ss.154 - 163. 10.30714/j-ebr.2021267979
AMA Türay S,hancı f,Ozde S An overview of vitamin B12 and iron deficiencies as a risk factors in children with febrile seizure etiology. Experimental Biomedical Research. 2021; 4(2): 154 - 163. 10.30714/j-ebr.2021267979
Vancouver Türay S,hancı f,Ozde S An overview of vitamin B12 and iron deficiencies as a risk factors in children with febrile seizure etiology. Experimental Biomedical Research. 2021; 4(2): 154 - 163. 10.30714/j-ebr.2021267979
IEEE Türay S,hancı f,Ozde S "An overview of vitamin B12 and iron deficiencies as a risk factors in children with febrile seizure etiology." Experimental Biomedical Research, 4, ss.154 - 163, 2021. 10.30714/j-ebr.2021267979
ISNAD Türay, Sevim vd. "An overview of vitamin B12 and iron deficiencies as a risk factors in children with febrile seizure etiology". Experimental Biomedical Research 4/2 (2021), 154-163. https://doi.org/10.30714/j-ebr.2021267979
Sayfa Oluşturulma Tarihi
17-04-2024 20:19

İLETİŞİM

TÜBİTAK ULAKBİM TR Dizin

Yüzüncüyıl, İşçi Blokları Mahallesi

Muhsin Yazıcıoğlu Caddesi No:51/C

06530 Çankaya / ANKARA +90 (312) 298 92 00

trdizin@tubitak.gov.tr

TÜBİTAK ULAKBİM Ulusal Akademik Ağ ve Bilgi Merkezi Cahit Arf Bilgi Merkezi © Tüm Hakları Saklıdır. Gizlilik Politikası Kullanım Şartları