(Hacettepe Üniversitesi, Perinatoloji Anabilim Dalı Kadın Hastalıkları ve Doğum Anabilim Dalı, Ankara, Türkiye)
(Hacettepe Üniversitesi, Perinatoloji Anabilim Dalı Kadın Hastalıkları ve Doğum Anabilim Dalı , Ankara, Türkiye)
Yıl: 2021Cilt: 27Sayı: 1ISSN: 1300-4751 / 2602-4918Sayfa Aralığı: 40 - 43İngilizce

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Evaluation and Management of Women who Have Experienced Stillbirth in Their Previous Pregnancies
OBJECTIVE: To evaluate the subsequent pregnancy outcomes of women who have experienced unexplained stillbirth in their previous gestations.STUDY DESIGN: This retrospective cohort consisted of 14 pregnancies who had stillbirth (withoutknown risk factors) in their previous pregnancies. These patients had been included in a special preconceptional care program to be evaluated in terms of etiological risk factors for stillbirth. At least oneof the risk factors, such as methylenetetrahydrofolate reductase polymorphisms, hereditary thrombophilias and autoimmune problems, were defined in this study population. After detection of pregnancy,the patients were administered low-dose low-molecular-weight heparin (enoxaparin, 1×2000 Anti-XAIU/0.2 mL/day), low-dose salicylic acid (100 mg/day) and low-dose corticosteroid (methylprednisolone,1×4 mg/day orally) in necessary cases.RESULTS: Out of 14 pregnancies, 4 (28.5%) ended up with miscarriages at 9, 11, 11 and 15 gestationalweeks, respectively. The remaining 10 pregnancies ended up with alive deliveries. The mean gestational week at birth was 36.4±0.51, while the mean birthweight was 2882±381.01 g. Out of 10 pregnancies, only one was diagnosed as IUGR. Only two newborn necessitated hospitalization in the neonatal intensive care unit due to respiratory problems. Both newborns were discharged from the neonatalintensive care unit without any further complication at the post-partum 5th day.CONCLUSION: Patients with a prior stillbirth should be screened for methylenetetrahydrofolate reductase polymorphisms, autoimmune problems and hereditary thrombophilias, especially in case of absence of any etiological factor. Management of these patients with low-dose aspirin, low-dose lowmolecular weight heparin and corticosteroids seemed to be beneficial for increasing live birth rates andavoiding obstetric complications.
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