Cadmium and other heavy metals which are commonly used in industry could threaten human health with both environmental and occupational exposures. Resveratrol, a natural polyphenol, is thought to have some properties such as anti-inflammatory, antioxidant, antitumor and immunomodulatory. Therefore, the present study was designed to examine the protective effect of resveratrol on cadmium toxicity in plasma, liver, kidney and heart tissue of mice. In our study, thirty five mice were equally divided into five groups. Control group, alcohol group, cadmium group (CdCl2, 1 mg/kg/day), resveratrol group (10 mg/kg/day), cadmium+resveratrol group (1 mg/kg/day+10 mg/kg/day). All treatments were administered orally via gavage for 21 days. The amount of malondialdehyde (MDA) and nitric oxide (NO) as an indicator of oxidative stress in liver, kidney, and heart tissue at the end of the application period, the amount of reduced glutathione (GSH) as a biomarker of antioxidant defense, total sialic acid (TSA) as an indicator of acute phase respon-se and aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT) activities in plasma were determined by spectrophotometric methods. In cadmium group, it was determined that tissue MDA, NO, TSA level and plasma AST, ALT, GGT activities increased significantly compared to control in the tissue (liver, kidney, and heart), while tissue GSH level decreased significantly compared to control. In cadmium+resveratrol group, it was determined that tissue MDA, NO, TSA level and plasma AST, ALT, GGT activities decreased, while tis-sue GSH level increased statistically significantly compared to cadmium groups. As a result, it was concluded that res-veratrol may have a protective effect on the liver, kidney and heart against the toxic effect of cadmium.