Yıl: 2020 Cilt: 5 Sayı: 4 Sayfa Aralığı: 317 - 322 Metin Dili: İngilizce DOI: 10.5152/cjms.2020.1937 İndeks Tarihi: 20-06-2021

Conservative Treatment for Locally Advanced Carcinoma of the Larynx Using Alpha-Crystalline B as a Prognostic Molecular Marker

Öz:
BACKGROUND/AIMSThis study was performed to understand the prognostic role of alpha-crystalline B (αBC) in locally advanced laryngeal cancer.MATERIAL and METHODSForty-five patients were enrolled; they were treated with induction chemotherapy followed by definitive radiotherapy. Alpha-crystalline B (αBC) was evaluated using quantitative real time-polymerase chain reaction.RESULTSComplete response to induction chemotherapy was observed in 16 patients, and partial response was achieved in 27 patients. After radiation therapy, 32 patients showed complete response. The αBC level was significantly higher in the tumor tissues than in the normal adjacent tissues. This level was significantly correlated with the patient’s age, clinical stage, and treatment response. High αBC levels were significantly associated with short overall and disease-free survival.CONCLUSIONInduction chemotherapy can efficiently preserve the larynx in a high proportion of patients. αBC can be used as a molecular marker for predicting the treatment response and survival in patients undergoing induction chemotherapy.
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  • 1. Sobczyk G, Kizler-Sobczyk K, Kawecki A, Krzeski A, Wójtowicz P. Total Laryngectomy with Radiotherapy in Stage T3-T4. Otolaryngol Head Neck Surg 2012; 147(2_suppl): 185. [Crossref]
  • 2. da Silva AP, Feliciano T, Freitas SV, Esteves S, e Sousa CA. Quality of life in patients submitted to total laryngectomy. J Voice 2015; 29(3): 382-8. [Crossref]
  • 3. Goyal S, Pounikar T, Jain P, Arya R, Verma J. Comparison of outcome and toxicity of two different regimes of neoadjuvant chemotherapy followed by external beam radiotherapy in stages III and IV larynx and laryngopharyngeal malignancies in years 2013-2014. J Cancer Res Ther 2016; 12(2): 920. [Crossref]
  • 4. Burgy M, Leblanc J, Borel C. Any place left for induction chemotherapy for locally advanced head and neck squamous cell carcinoma? Anticancer Drugs 2018; 29(4): 287-94. [Crossref]
  • 5. Yamamoto S, Yamashita A, Arakaki N, Nemoto H, Yamazaki T. Prevention of aberrant protein aggregation by anchoring the molecular chaperone αB-crystallin to the endoplasmic reticulum. Biochem Biophys Res Commun 2014; 455(3-4): 241-5. [Crossref]
  • 6. Carver JA, Grosas AB, Ecroyd H, Quinlan RA. The functional roles of the unstructured N-and C-terminal regions in αB-crystallin and other mammalian small heat-shock proteins. Cell Stress Chaperones 2017; 22(4): 627-38. [Crossref]
  • 7. Bakthisaran R, Akula KK, Tangirala R, Rao CM. Phosphorylation of αB-crystallin: role in stress, aging and patho-physiological conditions. Biochim Biophys Acta 2016; 1860(1): 167-82. [Crossref]
  • 8. Kannan R, Sreekumar PG, Hinton DR. Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration. Biochim Biophys Acta 2016; 1860(1): 258-68. [Crossref]
  • 9. Zhang J, Liu J, Wu J, Li W, Chen Z, Yang L. Progression of the role of CRYAB in signaling pathways and cancers. Onco Targets Ther 2019; 12: 4129-39. [Crossref]
  • 10. Kim MS, Lee HW, Jun SY, Lee EH. Expression of alpha B crystallin and BCL2 in patients with infiltrating ductal carcinoma. Int J Clin Exp Pathol 2015; 8(8): 8842.
  • 11. Tan L, Sha L, Hou N, Zhang M, Ma Q, Shi C. High α B-crystallin and p53 co-expression is associated with poor prognosis in ovarian cancer. Biosci Rep 2019; 39(6): BSR20182407. [Crossref]
  • 12. Lydiatt WM, Patel SG, O’Sullivan B, Brandwein MS, Ridge JA, Migliacci JC, et al. Head and neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clin 2017; 67(2): 122-37. [Crossref]
  • 13. Wang JR, Habbous S, Espin-Garcia O, Chen D, Huang SH, Simpson C, et al. Comorbidity and performance status as independent prognostic factors in patients with head and neck squamous cell carcinoma. Head Neck 2016; 38(5): 736-42. [Crossref]
  • 14. Subbiah V, Chuang HH, Gambhire D, Kairemo K. Defining clinical response criteria and early response criteria for precision oncology: current state-of-the-art and future perspectives. Diagnostics 2017; 7(1): 10. [Crossref]
  • 15. Ke AW, Shi GM, Zhou J, Wu FZ, Ding ZB, Hu MY, et al. Role of overexpression of CD151 and/or c‐Met in predicting prognosis of hepatocellular carcinoma. Hepatology 2009; 49(2): 491-503. [Crossref]
  • 16. Al-Mamgani A, Navran A, Walraven I, Schreuder WH, Tesselaar ME, Klop WM. Organ-preservation (chemo) radiotherapy for T4 laryngeal and hypopharyngeal cancer: is the effort worth? Eur Arch Otorhinolaryngol 2019 Feb; 276(2): 575-83. [Crossref]
  • 17. Goyal S, Patel PN, Gohil M, Suryanarayana U. Larynx preservation rate in laryngeal cancer patients treated with chemotherapy and radiotherapy: An institutional review of 250 patients. Acta Medica International 2016; 3(2): 141. [Crossref]
  • 18. Richard JM, Sancho-Garnier H, Pessey JJ, Luboinski B, Lefebvre JL, Dehesdin D, et al. Randomized trial of induction chemotherapy in larynx carcinoma. Oral Oncol 1998; 34(3): 224-8. [Crossref]
  • 19. Shirinian MH, Weber RS, Lippman SM, Dimery IW, Earley CL, Garden AS, et al. Laryngeal preservation by induction chemotherapy plus radiotherapy in locally advanced head and neck cancer: the MD Anderson Cancer Center experience. Head Neck 1994; 16(1): 39-44. [Crossref]
  • 20. Argiris A, Lefebvre JL. Laryngeal preservation strategies in locally advanced laryngeal and hypopharyngeal cancers. Front Oncol 2019; 9: 419. [Crossref]
  • 21. Patel SA, Qureshi MM, Dyer MA, Jalisi S, Grillone G, Truong MT. Comparing surgical and nonsurgical larynx‐preserving treatments with total laryngectomy for locally advanced laryngeal cancer. Cancer 2019; 125(19): 3367-77. [Crossref]
  • 22. Vilaseca I, Nogués‐Sabaté A, Avilés‐Jurado FX, Berenguer J, Grau JJ, Verger E, et al. Factors of local recurrence and organ preservation with transoral laser microsurgery in laryngeal carcinomas; CHAID decision‐tree analysis. Head Neck 2019; 41(3): 756-64. [Crossref]
  • 23. Dietz A, Wiegand S, Kuhnt T, Wichmann G. Laryngeal preservation approaches: considerations for new selection criteria based on the DeLOS-II trial. Front Oncol 2019; 9: 625. [Crossref]
  • 24. Tangsriwong K, Jitreetat T. Clinical Predictors of Laryngeal Preservation Rate in Stage III-IV Laryngeal Cancer and Hypopharyngeal Cancer Patients Treated with Organ Preservation. Asian Pacific journal of cancer prevention: Asian Pac J Cancer Prev 2019; 20(7): 2051-7. [Crossref]
  • 25. Wang Q, Liu Y, Wu K, Zhao Y, Gao C, Tong B, et al. Options of medical treatment and laryngeal function preservation in elderly patients with medial wall pyriform sinus cancer. Onco Targets Ther 2018; 11: 7441-6. [Crossref]
  • 26. Bonomi MR, Blakaj A, Blakaj D. Organ preservation for advanced larynx cancer: A review of chemotherapy and radiation combination strategies. Oral Oncol 2018; 86: 301-6. [Crossref]
  • 27. Kabarriti R, Brodin NP, Ahmed S, Vogelius I, Guha C, Kalnicki S, et al. Origin of Locoregional Recurrences After Definitive Intensity-modulated Radiation Therapy (IMRT) for Laryngeal Cancer Determined Based on Follow-up PET/CT Imaging. Cureus 2019; 11(1): e3856. [Crossref]
  • 28. Lu SM, Iganej S, Abdalla IA, Buchschacher GL. Concurrent Radiotherapy and Triweekly Carboplatin for the Definitive Treatment of Locally Advanced Laryngeal Carcinoma. Am J Clin Oncol 2018; 41(6): 595-600. [Crossref]
  • 29. Geretschläger A, Bojaxhiu B, Dal Pra A, Leiser D, Schmücking M, Arnold A, et al. Definitive intensity modulated radiotherapy in locally advanced hypopharygeal and laryngeal squamous cell carcinoma: mature treatment results and patterns of locoregional failure. Radiat Oncol 2015; 10(1): 20. [Crossref]
  • 30. Wylie JP, Sen M, Swindell R, Sykes AJ, Farrington WT, Slevin NJ. Definitive radiotherapy for 114 cases of T3N0 glottic carcinoma: influence of dose-volume parameters on outcome. Radiotherapy and Oncology 1999; 53(1): 15-21. [Crossref]
  • 31. Mao Y, Zhang DW, Lin H, Xiong L, Liu Y, Li QD, et al. Alpha B-crystallin is a new prognostic marker for laryngeal squamous cell carcinoma. J Exp Clin Cancer Res 2012; 31(1): 101. [Crossref]
  • 32. Yilmaz M, Karatas OF, Yuceturk B, Dag H, Yener M, Ozen M. Alpha‐B‐crystallin expression in human laryngeal squamous cell carcinoma tissues. Head Neck 2015; 37(9): 1344-8. [Crossref]
  • 33. Shi C, He Z, Hou N, Ni Y, Xiong L, Chen P. Alpha B-crystallin correlates with poor survival in colorectal cancer. Int J Clin Exp Pathol 2014; 7(9): 6056-63.
  • 34. Chen D, Cao G, Qiao C, Liu G, Zhou H, Liu Q. Alpha B‐crystallin promotes the invasion and metastasis of gastric cancer via NF‐κB‐induced epithelial‐mesenchymal transition. J Cell Mol Med 2018; 22(6): 3215-22. [Crossref]
APA Alzahrani R, Alghamdi D, Shami A, ELSAWY W, Gharib A, Amin H, AlMourgi M (2020). Conservative Treatment for Locally Advanced Carcinoma of the Larynx Using Alpha-Crystalline B as a Prognostic Molecular Marker. , 317 - 322. 10.5152/cjms.2020.1937
Chicago Alzahrani Rajab,Alghamdi Dr.AbdulRhman,Shami Ashjan,ELSAWY Wael H,Gharib Amal,Amin Hanan,AlMourgi Majed Conservative Treatment for Locally Advanced Carcinoma of the Larynx Using Alpha-Crystalline B as a Prognostic Molecular Marker. (2020): 317 - 322. 10.5152/cjms.2020.1937
MLA Alzahrani Rajab,Alghamdi Dr.AbdulRhman,Shami Ashjan,ELSAWY Wael H,Gharib Amal,Amin Hanan,AlMourgi Majed Conservative Treatment for Locally Advanced Carcinoma of the Larynx Using Alpha-Crystalline B as a Prognostic Molecular Marker. , 2020, ss.317 - 322. 10.5152/cjms.2020.1937
AMA Alzahrani R,Alghamdi D,Shami A,ELSAWY W,Gharib A,Amin H,AlMourgi M Conservative Treatment for Locally Advanced Carcinoma of the Larynx Using Alpha-Crystalline B as a Prognostic Molecular Marker. . 2020; 317 - 322. 10.5152/cjms.2020.1937
Vancouver Alzahrani R,Alghamdi D,Shami A,ELSAWY W,Gharib A,Amin H,AlMourgi M Conservative Treatment for Locally Advanced Carcinoma of the Larynx Using Alpha-Crystalline B as a Prognostic Molecular Marker. . 2020; 317 - 322. 10.5152/cjms.2020.1937
IEEE Alzahrani R,Alghamdi D,Shami A,ELSAWY W,Gharib A,Amin H,AlMourgi M "Conservative Treatment for Locally Advanced Carcinoma of the Larynx Using Alpha-Crystalline B as a Prognostic Molecular Marker." , ss.317 - 322, 2020. 10.5152/cjms.2020.1937
ISNAD Alzahrani, Rajab vd. "Conservative Treatment for Locally Advanced Carcinoma of the Larynx Using Alpha-Crystalline B as a Prognostic Molecular Marker". (2020), 317-322. https://doi.org/10.5152/cjms.2020.1937
APA Alzahrani R, Alghamdi D, Shami A, ELSAWY W, Gharib A, Amin H, AlMourgi M (2020). Conservative Treatment for Locally Advanced Carcinoma of the Larynx Using Alpha-Crystalline B as a Prognostic Molecular Marker. Cyprus Journal of Medical Sciences, 5(4), 317 - 322. 10.5152/cjms.2020.1937
Chicago Alzahrani Rajab,Alghamdi Dr.AbdulRhman,Shami Ashjan,ELSAWY Wael H,Gharib Amal,Amin Hanan,AlMourgi Majed Conservative Treatment for Locally Advanced Carcinoma of the Larynx Using Alpha-Crystalline B as a Prognostic Molecular Marker. Cyprus Journal of Medical Sciences 5, no.4 (2020): 317 - 322. 10.5152/cjms.2020.1937
MLA Alzahrani Rajab,Alghamdi Dr.AbdulRhman,Shami Ashjan,ELSAWY Wael H,Gharib Amal,Amin Hanan,AlMourgi Majed Conservative Treatment for Locally Advanced Carcinoma of the Larynx Using Alpha-Crystalline B as a Prognostic Molecular Marker. Cyprus Journal of Medical Sciences, vol.5, no.4, 2020, ss.317 - 322. 10.5152/cjms.2020.1937
AMA Alzahrani R,Alghamdi D,Shami A,ELSAWY W,Gharib A,Amin H,AlMourgi M Conservative Treatment for Locally Advanced Carcinoma of the Larynx Using Alpha-Crystalline B as a Prognostic Molecular Marker. Cyprus Journal of Medical Sciences. 2020; 5(4): 317 - 322. 10.5152/cjms.2020.1937
Vancouver Alzahrani R,Alghamdi D,Shami A,ELSAWY W,Gharib A,Amin H,AlMourgi M Conservative Treatment for Locally Advanced Carcinoma of the Larynx Using Alpha-Crystalline B as a Prognostic Molecular Marker. Cyprus Journal of Medical Sciences. 2020; 5(4): 317 - 322. 10.5152/cjms.2020.1937
IEEE Alzahrani R,Alghamdi D,Shami A,ELSAWY W,Gharib A,Amin H,AlMourgi M "Conservative Treatment for Locally Advanced Carcinoma of the Larynx Using Alpha-Crystalline B as a Prognostic Molecular Marker." Cyprus Journal of Medical Sciences, 5, ss.317 - 322, 2020. 10.5152/cjms.2020.1937
ISNAD Alzahrani, Rajab vd. "Conservative Treatment for Locally Advanced Carcinoma of the Larynx Using Alpha-Crystalline B as a Prognostic Molecular Marker". Cyprus Journal of Medical Sciences 5/4 (2020), 317-322. https://doi.org/10.5152/cjms.2020.1937