Effects of Fenofibrate Treatment on Aortic Stiffness in Patients with Pure Hypertriglyceridemia
Yıl: 2020 Cilt: 23 Sayı: 2 Sayfa Aralığı: 95 - 101 Metin Dili: İngilizce DOI: 10.5578/khj.69773 İndeks Tarihi: 20-06-2021
Effects of Fenofibrate Treatment on Aortic Stiffness in Patients with Pure Hypertriglyceridemia
Öz: Introduction: Hypertriglyceridemia is known as an independent risk factor for coronary artery disease (CAD).Fenofibrate that is used for the treatment of hypertriglyceridemia can prevent cardiovascular events in patientswith CAD. However, there is little information regarding the vascular effects of fenofibrate on arterial wall stiffness in patients with hypertriglyceridemia and without CAD, diabetes mellitus (DT), and hypertension (HT). Theobjective of this study is to evaluate the effects of fenofibrate treatment on the arterial stiffness in the patients withpure hypertriglyceridemia.Patients and Methods: We included 37 patients with hypertriglyceridemia without CAD, HT, and DT in thisstudy. We performed pre- and post-treament physical examination of the patients and took their blood samples. Patients were allocated fenofibrate for a duration of 168 ± 14 days for its administration. We assessedarterial stiffness by aortic pulse wave velocity (PWV) using a SphygmoCor device. Importantly, we estimatedcentral arterial pressure waveform parameters by radial artery applanation tonometry and used augmentationindex (AIx) as a measure of wave reflections.Results: Fenofibrate treatment resulted in significantly greater reductions in total cholesterol (201.3 ± 61.0mg/dL vs. 270.0 ± 93.4 mg/dL), triglycerides (261.3 ± 234.3 mg/dL vs. 704.7 ± 338.7 mg/dL), and the C/Hlevels (5.3 ± 2.6 vs. 7.2 ± 1.9, respectively) as compared with the pretreatment levels (p< 0.001). There wasa tendency of high-sensitivity C-reactive protein (hs-CRP) to decline after fenofibrate treatment as changein hs-CRP was significant (0.47 ± 0.41 mg/dL vs. 0.32 ± 0.31 mg/dL respectively, p< 0.01). AIx remainedunchanged from the pretreatment levels (24.2% ± 12.4% vs. 22.0% ± 11.4%, respectively, p> 0.05). Therewas a significant reduction in PWV after fenofibrate treatment (11.3 ± 2.9 m/s vs. 9.2 ± 2.2 m/s, p= 0.001).Conclusion: Fenofibrate treatment appears to effectively improve the arterial wall stiffness in the patients withpure hypertriglyceridemia.
Anahtar Kelime: İzole Hipertrigliseridemi Hastalarında Fenofibrat Tedavisinin Aortik Sertlik Üzerine Etkisi
Öz: Giriş: Hipertrigliseridemi, koroner arter hastalığı (KAH) için bağımsız bir risk faktörü olarak bilinir. Hipertrigliseridemi tedavisinde kullanılan fenofibratın KAH hastalarında kardiyovasküler olayları önleyebildiği bilinmektedir. Bununla birlikte, fenofibratın KAH’ı, diabetes mellitusu ve hipertansiyonu olmayan saf hipertrigliseridemi hastalarında arter duvar sertliği üzerindeki vasküler etkileri hakkında çok az bilgi vardır. Bu çalışmada saf hipertrigliseridemi hastalarında fenofibrat tedavisinin arteryel duvar sertliğe olan etkisini değerlendirmek amaçlanmıştır. Hastalar ve Yöntem: Çalışmaya KAH’ı, hipertansiyonu ve diabetes mellitusu olmayan 37 saf hipertrigliseridemi hastası dahil edildi. Tedavi öncesi ve sonrasında hastaların fizik muayeneleri yapıldı ve kan örnekleri alındı. Hastalara 168 ± 14 gün boyunca fenofibrat tedavisi verildi. Arteryel duvar sertliği, bir SphygmoCor cihazı kullanılarak aort nabız dalgası hızı (PWV) ile değerlendirildi. Santral arteryel basınç dalga formu parametreleri radyal arter aplikasyon tonometrisi ile hesaplandı ve dalga yansımasının ölçüsü olarak augmentasyon indeksi (AIx) kullanıldı. Bulgular: Fenofibrat tedavisi, tedavi öncesi ile karşılaştırıldığında toplam kolesterol, trigliserit ve C/H düzeylerinde belirgin şekilde anlamlı düşüşler sağlamıştır (201.3 ± 61.0 mg/dL, 270.0 ± 93.4 mg/dL ve 261.3 ± 234.3 mg/dL, 704.7 ± 338.7 mg/dL ve 5.3 ± 2.6 ve 7.2 ± 1.9, sırasıyla, p< 0.001). Hs-CRP’de fenofibrat tedavisinden sonra anlamlı düşme eğilimi tespit edilmiştir (sırasıyla 0.47 ± 0.41 mg/dL ve 0.32 ± 0.31 mg/dL, sırasıyla, p< 0.01). AIx’de anlamlı değişim izlenmemiştir (sırasıyla %24.2 ± 12.4 ve %22.0 ± 11.4, p> 0.05). Fenofibrat tedavisinden sonra PWV’de anlamlı bir azalma izlenmiştir (11.3 ± 2.9 m/s ve 9.2 ± 2.2 m/s, p= 0.001). Sonuç: Fenofibrat tedavisinin, saf hipertrigliseridemi hastalarında arteryel duvar sertliğini olumlu şekilde etkilediği gösterilmiştir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | efe s, Ozturk S, gurbuz a, Acar E, Yılmaz M, Kalkan S, Kirma C, Izgi I (2020). Effects of Fenofibrate Treatment on Aortic Stiffness in Patients with Pure Hypertriglyceridemia. , 95 - 101. 10.5578/khj.69773 |
| Chicago | efe suleyman,Ozturk Semi,gurbuz ahmet seyfeddin,Acar Emrah,Yılmaz Mehmet Fatih,Kalkan Sedat,Kirma Cevat,Izgi Ibrahim Akin Effects of Fenofibrate Treatment on Aortic Stiffness in Patients with Pure Hypertriglyceridemia. (2020): 95 - 101. 10.5578/khj.69773 |
| MLA | efe suleyman,Ozturk Semi,gurbuz ahmet seyfeddin,Acar Emrah,Yılmaz Mehmet Fatih,Kalkan Sedat,Kirma Cevat,Izgi Ibrahim Akin Effects of Fenofibrate Treatment on Aortic Stiffness in Patients with Pure Hypertriglyceridemia. , 2020, ss.95 - 101. 10.5578/khj.69773 |
| AMA | efe s,Ozturk S,gurbuz a,Acar E,Yılmaz M,Kalkan S,Kirma C,Izgi I Effects of Fenofibrate Treatment on Aortic Stiffness in Patients with Pure Hypertriglyceridemia. . 2020; 95 - 101. 10.5578/khj.69773 |
| Vancouver | efe s,Ozturk S,gurbuz a,Acar E,Yılmaz M,Kalkan S,Kirma C,Izgi I Effects of Fenofibrate Treatment on Aortic Stiffness in Patients with Pure Hypertriglyceridemia. . 2020; 95 - 101. 10.5578/khj.69773 |
| IEEE | efe s,Ozturk S,gurbuz a,Acar E,Yılmaz M,Kalkan S,Kirma C,Izgi I "Effects of Fenofibrate Treatment on Aortic Stiffness in Patients with Pure Hypertriglyceridemia." , ss.95 - 101, 2020. 10.5578/khj.69773 |
| ISNAD | efe, suleyman vd. "Effects of Fenofibrate Treatment on Aortic Stiffness in Patients with Pure Hypertriglyceridemia". (2020), 95-101. https://doi.org/10.5578/khj.69773 |
| APA | efe s, Ozturk S, gurbuz a, Acar E, Yılmaz M, Kalkan S, Kirma C, Izgi I (2020). Effects of Fenofibrate Treatment on Aortic Stiffness in Patients with Pure Hypertriglyceridemia. Koşuyolu Heart Journal, 23(2), 95 - 101. 10.5578/khj.69773 |
| Chicago | efe suleyman,Ozturk Semi,gurbuz ahmet seyfeddin,Acar Emrah,Yılmaz Mehmet Fatih,Kalkan Sedat,Kirma Cevat,Izgi Ibrahim Akin Effects of Fenofibrate Treatment on Aortic Stiffness in Patients with Pure Hypertriglyceridemia. Koşuyolu Heart Journal 23, no.2 (2020): 95 - 101. 10.5578/khj.69773 |
| MLA | efe suleyman,Ozturk Semi,gurbuz ahmet seyfeddin,Acar Emrah,Yılmaz Mehmet Fatih,Kalkan Sedat,Kirma Cevat,Izgi Ibrahim Akin Effects of Fenofibrate Treatment on Aortic Stiffness in Patients with Pure Hypertriglyceridemia. Koşuyolu Heart Journal, vol.23, no.2, 2020, ss.95 - 101. 10.5578/khj.69773 |
| AMA | efe s,Ozturk S,gurbuz a,Acar E,Yılmaz M,Kalkan S,Kirma C,Izgi I Effects of Fenofibrate Treatment on Aortic Stiffness in Patients with Pure Hypertriglyceridemia. Koşuyolu Heart Journal. 2020; 23(2): 95 - 101. 10.5578/khj.69773 |
| Vancouver | efe s,Ozturk S,gurbuz a,Acar E,Yılmaz M,Kalkan S,Kirma C,Izgi I Effects of Fenofibrate Treatment on Aortic Stiffness in Patients with Pure Hypertriglyceridemia. Koşuyolu Heart Journal. 2020; 23(2): 95 - 101. 10.5578/khj.69773 |
| IEEE | efe s,Ozturk S,gurbuz a,Acar E,Yılmaz M,Kalkan S,Kirma C,Izgi I "Effects of Fenofibrate Treatment on Aortic Stiffness in Patients with Pure Hypertriglyceridemia." Koşuyolu Heart Journal, 23, ss.95 - 101, 2020. 10.5578/khj.69773 |
| ISNAD | efe, suleyman vd. "Effects of Fenofibrate Treatment on Aortic Stiffness in Patients with Pure Hypertriglyceridemia". Koşuyolu Heart Journal 23/2 (2020), 95-101. https://doi.org/10.5578/khj.69773 |
