Yıl: 2021 Cilt: 18 Sayı: 1 Sayfa Aralığı: 7 - 14 Metin Dili: İngilizce DOI: 10.4274/tjod.galenos.2021.28938 İndeks Tarihi: 20-06-2021

Cervical dysplasia after renal transplantation: A retrospective cohort study

Öz:
Objective: Since the first days of organ transplantation, it has been accepted that solid transplant recipients have a high risk of developing cancer. Chronicimmunosuppression and environmental factors play a role in cancer development in recipients. In the present study, we tried to evaluate the cumulativeincidence of cervical dysplasia after renal transplantation, risk factors for disease development, and the time until high-grade dysplasia occurred.Materials and Methods: A total of 50 patients with renal transplantation who presented for gynecologic follow-up was included in the study. The medicalrecords of the patients were reviewed until the last clinical visit, their demographic characteristics, transplant history, gynecologic history, and gynecologicexamination results (cervical cytology and histology reports) were reviewed.Results: Of the 50 women in the study population, 29 (58%; 95% confidence interval: 8.8-15.9) developed cervical dysplasia after the first transplant ata median follow-up of 7.8 (range: 4.6-12.9) years. Twenty-one women with benign cervical cytology before transplantation had evidence of low-gradeintraepithelial lesions + after transplant (47% of these were within 2 years after transplant). During the follow-up, 8 women (18.2%) were diagnosed ashaving high-grade intraepithelial lesions + (within 5 years after transplantation).Conclusion: Renal transplant patients were found to have higher abnormal cervical cytology and histology rates than the normal population.
Anahtar Kelime:

Renal transplantasyon sonrası servikal displazi: Retrospektif bir kohort çalışması

Öz:
Amaç: Organ naklinin ilk günlerinden bu yana, nakil alıcılarının kansere yakalanma riskinin yüksek olduğu kabul edilmiştir. Kronik immünosüpresyon ve çevresel faktörler, alıcılarda kanser gelişiminde rol oynar. Sunulan çalışmada, renal transplantasyon sonrası kümülatif servikal displazi insidansını, hastalık gelişimi için risk faktörlerini ve yüksek dereceli displazinin ortaya çıkmasına kadar geçen süreyi değerlendirmeye çalıştık. Gereç ve Yöntemler: Çalışmaya jinekolojik takip için başvuran toplam 50 renal transplantasyon hastası dahil edildi. Hastaların tıbbi kayıtları son klinik ziyarete kadar gözden geçirildi, demografik özellikleri, nakil öyküleri, jinekolojik öyküleri ve jinekolojik muayene sonuçları (servikal sitoloji ve histoloji raporları) gözden geçirildi. Bulgular: Çalışma popülasyonundaki 50 kadından 29’u (%58; %95 güven aralığı: 8,8-15,9) ortalama 7,8 yıllık bir takip süresinde (4,6-12,9) ilk nakilden sonra servikal displazi geliştirdi. Transplantasyondan önce benign servikal sitolojisi olan 21 kadında, transplantasyondan sonra düşük derecede intraepitelyal lezyonlar + kanıtı vardı (bunların %47’si transplantasyondan sonraki 2 yıl içinde idi). Takip sırasında 8 kadına (%18,2) yüksek dereceli intraepitelyal lezyonlar + (transplantasyondan sonraki 5 yıl içinde) tanısı kondu. Sonuç: Böbrek nakli hastalarının normal popülasyona göre daha yüksek anormal servikal sitoloji ve histoloji oranlarına sahip olduğu bulunmuştur.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA bilgi a, Gokulu S, Kurt S, kulhan m, akgün kavurmacı s, Töz H, Terek M (2021). Cervical dysplasia after renal transplantation: A retrospective cohort study. , 7 - 14. 10.4274/tjod.galenos.2021.28938
Chicago bilgi ahmet,Gokulu Sevki Goksun,Kurt Sefa,kulhan mehmet,akgün kavurmacı seda,Töz Hüseyin,Terek Mustafa Cosan Cervical dysplasia after renal transplantation: A retrospective cohort study. (2021): 7 - 14. 10.4274/tjod.galenos.2021.28938
MLA bilgi ahmet,Gokulu Sevki Goksun,Kurt Sefa,kulhan mehmet,akgün kavurmacı seda,Töz Hüseyin,Terek Mustafa Cosan Cervical dysplasia after renal transplantation: A retrospective cohort study. , 2021, ss.7 - 14. 10.4274/tjod.galenos.2021.28938
AMA bilgi a,Gokulu S,Kurt S,kulhan m,akgün kavurmacı s,Töz H,Terek M Cervical dysplasia after renal transplantation: A retrospective cohort study. . 2021; 7 - 14. 10.4274/tjod.galenos.2021.28938
Vancouver bilgi a,Gokulu S,Kurt S,kulhan m,akgün kavurmacı s,Töz H,Terek M Cervical dysplasia after renal transplantation: A retrospective cohort study. . 2021; 7 - 14. 10.4274/tjod.galenos.2021.28938
IEEE bilgi a,Gokulu S,Kurt S,kulhan m,akgün kavurmacı s,Töz H,Terek M "Cervical dysplasia after renal transplantation: A retrospective cohort study." , ss.7 - 14, 2021. 10.4274/tjod.galenos.2021.28938
ISNAD bilgi, ahmet vd. "Cervical dysplasia after renal transplantation: A retrospective cohort study". (2021), 7-14. https://doi.org/10.4274/tjod.galenos.2021.28938
APA bilgi a, Gokulu S, Kurt S, kulhan m, akgün kavurmacı s, Töz H, Terek M (2021). Cervical dysplasia after renal transplantation: A retrospective cohort study. Turkish Journal of Obstetrics and Gynecology, 18(1), 7 - 14. 10.4274/tjod.galenos.2021.28938
Chicago bilgi ahmet,Gokulu Sevki Goksun,Kurt Sefa,kulhan mehmet,akgün kavurmacı seda,Töz Hüseyin,Terek Mustafa Cosan Cervical dysplasia after renal transplantation: A retrospective cohort study. Turkish Journal of Obstetrics and Gynecology 18, no.1 (2021): 7 - 14. 10.4274/tjod.galenos.2021.28938
MLA bilgi ahmet,Gokulu Sevki Goksun,Kurt Sefa,kulhan mehmet,akgün kavurmacı seda,Töz Hüseyin,Terek Mustafa Cosan Cervical dysplasia after renal transplantation: A retrospective cohort study. Turkish Journal of Obstetrics and Gynecology, vol.18, no.1, 2021, ss.7 - 14. 10.4274/tjod.galenos.2021.28938
AMA bilgi a,Gokulu S,Kurt S,kulhan m,akgün kavurmacı s,Töz H,Terek M Cervical dysplasia after renal transplantation: A retrospective cohort study. Turkish Journal of Obstetrics and Gynecology. 2021; 18(1): 7 - 14. 10.4274/tjod.galenos.2021.28938
Vancouver bilgi a,Gokulu S,Kurt S,kulhan m,akgün kavurmacı s,Töz H,Terek M Cervical dysplasia after renal transplantation: A retrospective cohort study. Turkish Journal of Obstetrics and Gynecology. 2021; 18(1): 7 - 14. 10.4274/tjod.galenos.2021.28938
IEEE bilgi a,Gokulu S,Kurt S,kulhan m,akgün kavurmacı s,Töz H,Terek M "Cervical dysplasia after renal transplantation: A retrospective cohort study." Turkish Journal of Obstetrics and Gynecology, 18, ss.7 - 14, 2021. 10.4274/tjod.galenos.2021.28938
ISNAD bilgi, ahmet vd. "Cervical dysplasia after renal transplantation: A retrospective cohort study". Turkish Journal of Obstetrics and Gynecology 18/1 (2021), 7-14. https://doi.org/10.4274/tjod.galenos.2021.28938