Hidayet ŞAL
(Karadeniz Teknik Üniversitesi, Kadın Hastalıkları ve Doğum Anabilim Dalı,Trabzon, Türkiye)
Erhan CÖMERT
(Karadeniz Teknik Üniversitesi, Kadın Hastalıkları ve Doğum Anabilim Dalı,Trabzon, Türkiye)
Yasin Semih EKİNCİ
(Karadeniz Teknik Üniversitesi, Kadın Hastalıkları ve Doğum Anabilim Dalı,Trabzon, Türkiye)
Turhan ARAN
(Karadeniz Teknik Üniversitesi, Kadın Hastalıkları ve Doğum Anabilim Dalı,Trabzon, Türkiye)
Yıl: 2021Cilt: 27Sayı: 1ISSN: 1300-4751 / 2602-4918Sayfa Aralığı: 1 - 5İngilizce

94 0
Perinatal Outcome of Fetal Echogenic Bowel: A Single-Center Retrospective Cohort Study
OBJECTIVE: The aim of this study is to evaluate perinatal outcome of fetal echogenic bowel.STUDY DESIGN: In this retrospective cohort study, fetuses with echogenic bowel diagnosed and followed in our center between 2013-2017 were included. Fetuses and infants were evaluated in terms ofantenatal comorbidities and postnatal persistent diseases. Infants were followed-up to June 2018 fromtime of diagnosis. Demographic questionnaire and face to face interview were used to obtain data including immune system diseases and respiratory system pathologies in infants.RESULTS: A total of 100 fetuses with echogenic bowel were included in the study. Fetal aneuploidy wasdetected in 7 (7%) cases. Trisomy 21 was the most common aneuploidy and identified in 4 (4%) cases.Other chromosomal disorders were tetrasomy 12p (1%), 69XXX (1%) and 46 XX, t (2,22) (9q9) (1%). Afetal echogenic bowel was associated with major congenital malformations in 25 (%25) cases. Cardiacabnormality was the most prevalent (%7). First and second trimester vaginal bleeding history was foundin 5 pregnant women. In 3 case with isolated echogenic bowel (no congenital malformation and aneuploidy), lactose intolerance, celiac disease, and non-obstructive hydrocephalus were diagnosed in earlychildhood.CONCLUSION: Isolated fetal echogenic bowel which can be considered as a soft marker for aneuploidymay be associated with lactose intolerance and celiac disease. Further clinical studies are warranted toevaluate this relationship.
DergiAraştırma MakalesiErişime Açık
  • 1. Sukupova M. Dhaifalah I. Adamik Z. Havalova J. Hyperechogenic fetal bowel as a marker of fetal cystic fibrosis. Ceska Gynekol. 2015;80(1):20-4.
  • 2. Catania VD. Taddei A. Pellegrino M. De Marco EA. Merli L. Manzoni C. et al. Hyperechogenic Bowel: Etiologies, Management, and Outcome according to Gestational Age at Diagnosis in 279 Consecutive Cases in a Single Center. Eur J Pediatr Surg. 2017;27(1):109-15. doi: 10.1055/s-0036-1597671.
  • 3. Masini G, Maggio L, Marchi L, Cavalli I, Ledda C, Trotta M, et al. Isolated fetal echogenic bowel in a retrospective cohort: The role of infection screening. Eur J Obstet Gynecol Reprod Biol. 2018;231:136-41.
  • 4. Lince DM, Pretorius DH, Manco-Johnson ML, Manchester D, Clewell WH. The clinical significance of increased echogenicity in the fetal abdomen. AJR Am J Roentgenol. 1985;145(4):683-6.
  • 5. Buiter HD, Holswilder-Olde Scholtenhuis MA, Bouman K, van Baren R, Bilardo CM, Bos AF. Outcome of infants presenting with echogenic bowel in the second trimester of pregnancy. Arch Dis Child Fetal Neonatal Ed. 2013;98(3):F256-9.
  • 6. Ekin A. Gezer C. Taner CE. Ozeren M. The effect of associated structural malformations in the prediction of chromosomal abnormality risk of fetuses with echogenic bowel. J Matern Fetal Neonatal Med. 2016;29(1):41-5. doi: 10.3109/14767058.2014.986091.
  • 7. De Oronzo MA. Hyperechogenic fetal bowel: an ultrasonographic marker for adverse fetal and neonatal outcome? J Prenat Med. 2011;5(1):9-13.
  • 8. Jackson CR. Orford J. Minutillo C. Dickinson JE. Dilated and echogenic fetal bowel and postnatal outcomes: a surgical perspective. Case series and literature review. Eur J Pediatr Surg. 2010;20(3):191-3. doi:10.1055/s-0030- 1247523.
  • 9. Miller ME. Allen VM. Brock JK. Incidence and Carrier Frequency of CFTR Gene Mutations in Pregnancies With Echogenic Bowel in Nova Scotia and Prince Edward Island. J Obstet Gynaecol Can. 2018;40(7):896-902. doi: 10.1016/j.jogc.2017.11.021.
  • 10. Ronin C. Mace P. Stenard F. Loundou A. Capelle M. Mortier I. et al. Antenatal prognostic factor of fetal echogenic bowel. Eur J Obstet Gynecol Reprod Biol. 2017;212:166-70. doi: 10.1016/j.ejogrb.2017.01.060.
  • 11. Mailath-Pokorny M. Klein K. Klebermass-Schrehof K. 5 Sal H. Comert EH. Ekici YS. Aran T. Hachemian N. Bettelheim D. Are fetuses with isolated echogenic bowel at higher risk for an adverse pregnancy outcome? Experiences from a tertiary referral center. Prenat Diagn. 2012;32(13):1295-9. doi: 10.1002/pd.3999.
  • 12. Nigro G. Adler SP. Gatta E. Mascaretti G. Megaloikonomou A. La Torre R. et al. Fetal hyperechogenic bowel may indicate congenital cytomegalovirus disease responsive to immunoglobulin therapy. J Matern Fetal Neonatal Med. 2012;25(11):2202-5. doi: 10.3109/ 14767058.2012.684111.
  • 13. Singer A. Maya I. Koifman A. Nasser Samra N. Baris HN. Falik-Zaccai T. et al. Microarray analysis in pregnancies with isolated echogenic bowel. Early Hum Dev. 2018;119:25-8. doi: 10.1016/j.earlhumdev.2018.02.014.
  • 14. World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310 (20): 2191-4. doi: 10.1001/jama.2013.281053.
  • 15. Woodfield C. Obstetrical Ultrasonography in the Second Trimester. In: Torigian D. Ramchandani P. editor. Radiology Secrets Plus. 4th ed. Philadelphia: Elsevier; 2016. p. 592-601.
  • 16. Bashiri A. Burstein E. Hershkowitz R. Mazor M. Fetal echogenic bowel by ultrasound: what is the clinical significance? Harefuah. 2007;146(12):964-9, 96-7.
  • 17. Maillet L. Rudigoz RC. Buffin R. Massardier J. Gaucherand P. Huissoud C. Neonatal outcome of fetal hyperechogenic bowel. Gynecol Obstet Fertil. 2014;42(6): 383-6. doi: 10.1016/j.gyobfe.2014.01.006.
  • 18. Iruretagoyena JI. Bankowsky H. Heiser T. Birkeland L. Grady M, Shah D. Outcomes for fetal echogenic bowel during the second trimester ultrasound. J Matern Fetal Neonatal Med. 2010;23(11):1271-3. doi: 10.3109/ 14767050903551442.
  • 19. Rink BD. Norton ME. Screening for fetal aneuploidy. Semin Perinatol. 2016;40(1):35-43. doi: 10.1053/j.semperi.2015.11.006.
  • 20. Celen SO A. Dover N. Aydogan P. Mollamahmudoglu L. Danısman N. Second Trimester Ultrasonographic Findings in Aneuploidic Fetuses: Zekai Tahir Burak Women’s Health Education and Research Hospital Perinatology Clinic Experiences. Cumhuriyet Med J. 1305-0028.1166.
  • 21. Findley R. Allen VM. Brock JK. Adverse Perinatal Conditions Associated With Prenatally Detected Fetal Echogenic Bowel in Nova Scotia. J Obstet Gynaecol Can. 2018;40(5):555-60. doi: 10.1016/j.jogc.2017.09.017.
  • 22. Ameratunga DM. Said JM. Reidy K. Palma-Dias R. Perinatal outcomes following the ultrasound diagnosis of echogenic bowel: an Australian perspective. Fetal Diagn Ther. 2012;31(3):179-84. doi: 10.1159/000336123.
  • 23. Ecevit Aİ. İnce DA. Kurt A. Tarcan A. Yanık F. Fetal Hyperechogenic Bowel and Early Necrotizing Enterocolitis in Three Intrauterine Growth Restricted, Extremely Low Birth Weight Infants. Perinat J 2011; 19(2):99-102.
  • 24. Jessula S. Van Den Hof M. Mateos-Corral D. Mills J. Davies D. Romao RL. Predictors for surgical intervention and surgical outcomes in neonates with cystic fibrosis. J Pediatr Surg. 2018;53(11):2150-4. doi: 10.1016/j.jpedsurg.2018.05.016.
  • 25. Bleu G. Coulon C. Vaast P. Bourgeot P. Sfeir R. Boute O. et al. Hyperechogenic fetal bowel: Which fetal and neonatal outcome? A French study of 149 cases. J Gynecol Obstet Biol Reprod (Paris). 2015;44(6):558-64. doi: 10.1016/j.jgyn.2014.08.004.
  • 26. Kazandi M. Turan V. Selvi Demirtas G. Akercan F. Aykut A. Ozkinay F. Mid-trimester hyperechogenic bowel in a fetus of Turkish origin carrying a rarely seen mutation of cystic fibrosis. Arch Iran Med. 2012;15(7):449-51.
  • 27. Scotet V. Dugueperoux I. Audrezet MP. AudebertBellanger S. Muller M. Blayau M. et al. Focus on cystic fibrosis and other disorders evidenced in fetuses with sonographic finding of echogenic bowel: 16-year report from Brittany, France. Am J Obstet Gynecol. 2010;203 (6):592 e1-6. doi: 10.1016/j.ajog.2010.08.033.
  • 28. Egic A. Mikovic Z. Mandic V. Karadzov N. Prenatal diagnosis of meconium ileus and meconium peritonitis: indications for cystic fibrosis testing. Srp Arh Celok Lek. 2011;139(7-8):527-30. doi: 10.2298/sarh1108527e.
  • 29. Saha E. Mullins EW. Paramasivam G. Kumar S. Lakasing L. Perinatal outcomes of fetal echogenic bowel. Prenat Diagn. 2012;32(8):758-64. doi: 10.1002/pd.3898.
  • 30. Petrikovsky B. Smith-Levitin M. Holsten N. Intra-amniotic bleeding and fetal echogenic bowel. Obstet Gynecol. 1999;93(5 Pt 1):684-6. doi:10.1016/s0029-7844(98) 00528-6.

TÜBİTAK ULAKBİM Ulusal Akademik Ağ ve Bilgi Merkezi Cahit Arf Bilgi Merkezi © 2019 Tüm Hakları Saklıdır.